DOI: 10.1002/jbmr.5650110704. Amelin: An enamel-related protein, transcribed in the cells of epithelial root sheath

Amelin: An enamel-related protein, transcribed in the cells of epithelial root sheath

10.1002/jbmr.5650110704

Crossref journal-article

Oxford University Press (OUP)

Journal of Bone and Mineral Research (286)

Abstract

Abstract Since 1974, when Slavkin and his collaborators proposed the epithelial origin of cementum, many experiments have been carried out to provide evidence for deposition of enamel-related proteins along the root surface. However, neither amelogenin nor other proteins have fully satisfied expectations. In previous studies, we have identified a novel mRNA coding for an extracellular-like protein which we called amelin. It was expressed at high levels in secretory and postsecretory ameloblasts in rat molars and incisors. In situ hybridization experiments described in the present study also localized the amelin message to epithelial cells adjacent to the peripheral surface of newly deposited dentin in the root end and to cells embedded in cellular cementum in molars. In incisors, the amelin RNA positive cells were detected in the area where cementum formation had been initiated. No amelogenin RNA signal was found in the cells at the root surface. We postulate that the epithelial cells of the root sheath as well as the ameloblasts are synthesizing amelin which might be one of the key proteins coupled to the process of cementogenesis. (J Bone Miner Res 1996;11:892-898)

Bibliography

Fong, C. D., Slaby, I., & HammarstrÃ¶m, L. (1996). Amelin: An enamel-related protein, transcribed in the cells of epithelial root sheath. Journal of Bone and Mineral Research, 11(7), 892â898.

Authors 3

Cheng Dan Fong (first)
Ivan Slaby (additional)
Lars Hammarström (additional)

References 25 Referenced 102

10.1016/S0022-5320(69)90020-3 / J Ultrastruct Res / The incorporation of epithelial cells by cementum by Lester (1969)
10.1016/S0022-5320(69)80035-3 / J Ultrastruct Res / The unusual nature of root formation in molar teeth of the laboratory rat by Lester (1969)
10.3109/00016356308993957 / Acta Odontol Scand / Electron microscopy of Hertwig's epithelial sheath and of early dentin and cementum formation in the mouse incisor by Selvig (1963)
{'key': '2024013114261460300_bib4', 'first-page': '183', 'article-title': 'A fine structural study of coronal and root dentinogenesis in the mouse: Observations on the so-called ‘von Korff fibers’ and their contribution to mantle dentine', 'volume': '125', 'author': 'Ten Cate', 'year': '1978', 'journal-title': 'J Anat'} / J Anat / A fine structural study of coronal and root dentinogenesis in the mouse: Observations on the so-called ‘von Korff fibers’ and their contribution to mantle dentine by Ten Cate (1978)
10.1016/0003-9969(79)90215-2 / Archs Oral Biol / A light and electron microscopic study of the early stages of root surface formation in molar teeth in the rat by Owens (1980)
10.1016/0003-9969(89)90043-5 / Archs Oral Biol / Differentiation of odontoblasts in grafted recombinants of murine epithelial root sheath and dental mesenchyme by Thomas (1989)
{'key': '2024013114261460300_bib7', 'first-page': '157', 'article-title': 'Cementum: An epithelial secretory product?', 'volume': '53', 'author': 'Slavkin', 'year': '1974', 'journal-title': 'J Dent Res'} / J Dent Res / Cementum: An epithelial secretory product? by Slavkin (1974)
10.1177/002203457505400308011 / J Dent Res / Demonstration of an alloimmune response to embryonic enamel matrix proteins by Schonfeld (1975)
{'key': '2024013114261460300_bib9', 'first-page': '28', 'article-title': "Hertwig's epithelial root sheath differentiation and initial cementum and bone formation during long-term organ culture of mouse mandibular first molars using serumless, chemically-defined medium", 'volume': '23', 'author': 'Slavkin', 'year': '1988', 'journal-title': 'J Periodontal Res'} / J Periodontal Res / Hertwig's epithelial root sheath differentiation and initial cementum and bone formation during long-term organ culture of mouse mandibular first molars using serumless, chemically-defined medium by Slavkin (1988)
10.1016/0304-4165(89)90021-4 / Biochem Biophys Acta / Human and mouse cementum proteins immunologically related to enamel proteins by Slavkin (1989)
{'key': '2024013114261460300_bib11', 'first-page': '172', 'article-title': 'Formation of intermediate cementum III: 3H-tryptophane and 3H-proline uptake into the epithelial root sheath of Hertwig in vitro', 'volume': '2', 'author': 'Lindskog', 'year': '1982', 'journal-title': 'J Craniofac Genet Dev Biol'} / J Craniofac Genet Dev Biol / Formation of intermediate cementum III: 3H-tryptophane and 3H-proline uptake into the epithelial root sheath of Hertwig in vitro by Lindskog (1982)
{'key': '2024013114261460300_bib12', 'first-page': '147', 'article-title': 'Formation of intermediate cementum I: Early mineralization of aprismatic enamel and intermediate cementum in monkey', 'volume': '2', 'author': 'Lindskog', 'year': '1982', 'journal-title': 'J Craniofac Genet Dev Biol'} / J Craniofac Genet Dev Biol / Formation of intermediate cementum I: Early mineralization of aprismatic enamel and intermediate cementum in monkey by Lindskog (1982)
{'key': '2024013114261460300_bib13', 'first-page': '161', 'article-title': 'Formation of intermediate cementum II: A scanning electron microscopic study of the epithelial root sheath of Hertwig in monkey', 'volume': '2', 'author': 'Lindskog', 'year': '1982', 'journal-title': 'J Craniofac Genet Dev Biol'} / J Craniofac Genet Dev Biol / Formation of intermediate cementum II: A scanning electron microscopic study of the epithelial root sheath of Hertwig in monkey by Lindskog (1982)
10.1111/j.1600-0765.1991.tb01624.x / J Periodontal Res / Cells from Hertwig's epithelial root sheath do not transcribe amelogenin by Luo (1991)
10.1002/jbmr.5650110703 / J Bone Miner Res / A novel gene expressed in rat ameloblasts codes for proteins with cell binding domains by Cerny (1996)
{'key': '2024013114261460300_bib16', 'author': 'Fong', 'year': '1996'} by Fong (1996)
10.1074/jbc.271.8.4431 / J Biol Chem / Full-length sequence, localization, and chromosomal mapping of ameloblastin: a novel tooth-specific gene by Krebsbach (1996)
10.2220/biomedres.16.131 / Biomed Res / Immunochemical and immunocytochemical study of a 15 kDa non-amelogenin and related proteins in the porcine immature enamel: Proposal of a new group of enamel proteins ‘sheath proteins.’ by Uchida (1995)
{'key': '2024013114261460300_bib19', 'first-page': '1', 'volume-title': 'Current Protocols in Molecular Biology', 'author': 'Watkins', 'year': '1994'} / Current Protocols in Molecular Biology by Watkins (1994)
{'key': '2024013114261460300_bib20', 'first-page': '173', 'article-title': 'Epithelial-mesenchymal interactions in tooth germs: mechanisms of differentiation', 'volume': '11', 'author': 'Ruch', 'year': '1983', 'journal-title': 'J Biol Buccale'} / J Biol Buccale / Epithelial-mesenchymal interactions in tooth germs: mechanisms of differentiation by Ruch (1983)
{'key': '2024013114261460300_bib21', 'first-page': '189', 'article-title': 'The nature and nurture of epithelial-mesenchymal interactons during tooth morphogenesis', 'volume': '6', 'author': 'Slavkin', 'year': '1979', 'journal-title': 'J Biol Buccale'} / J Biol Buccale / The nature and nurture of epithelial-mesenchymal interactons during tooth morphogenesis by Slavkin (1979)
10.1111/j.1432-0436.1981.tb01107.x / Differentiation / Tissue interactions in tooth development by Thesleff (1981)
{'key': '2024013114261460300_bib23', 'first-page': '179', 'article-title': 'Molecular changes during determination and differentiation of the dental mesenchymal cell lineage', 'volume': '18', 'author': 'Thesleff', 'year': '1990', 'journal-title': 'J Biol Buccale'} / J Biol Buccale / Molecular changes during determination and differentiation of the dental mesenchymal cell lineage by Thesleff (1990)
10.1111/j.1432-0436.1989.tb00732.x / Differentiation / Amelogenin gene expression in mouse incisor heterotopic recombinations by Amar (1989)
10.1111/j.1432-0436.1988.tb00793.x / Differentiation / Sequential expression and differential function of multiple enamel proteins during fetal, neonatal, and early postnatal stages of mouse molar organogenesis by Slavkin (1988)

Dates

Type	When
Created	15 years, 7 months ago (Feb. 3, 2010, 10:35 a.m.)
Deposited	1 year, 5 months ago (March 13, 2024, 11:02 a.m.)
Indexed	11 months, 4 weeks ago (Sept. 8, 2024, 4:19 p.m.)
Issued	29 years, 2 months ago (July 1, 1996)
Published	29 years, 2 months ago (July 1, 1996)
Published Online	29 years, 2 months ago (July 1, 1996)
Published Print	29 years, 2 months ago (July 1, 1996)

Funders 0

None

BibTeX

@article{Fong_1996, title={Amelin: An enamel-related protein, transcribed in the cells of epithelial root sheath}, volume={11}, ISSN={1523-4681}, url={http://dx.doi.org/10.1002/jbmr.5650110704}, DOI={10.1002/jbmr.5650110704}, number={7}, journal={Journal of Bone and Mineral Research}, publisher={Oxford University Press (OUP)}, author={Fong, Cheng Dan and Slaby, Ivan and Hammarström, Lars}, year={1996}, month=jul, pages={892–898} }

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