DOI: 10.1002/jbmr.5650080604. Determinants of bone mineral density and risk factors for osteoporosis in healthy elderly women

Determinants of bone mineral density and risk factors for osteoporosis in healthy elderly women

10.1002/jbmr.5650080604

Crossref journal-article

Oxford University Press (OUP)

Journal of Bone and Mineral Research (286)

Abstract

Abstract Bone mineral density (BMD) and risk factors for osteoporosis were assessed in 348 apparently healthy women over 70 years of age (mean 82.3 years). BMD was measured at both hips and the dominant distal radius. With stepwise multiple regression the best determinants of BMD, selected from anthropometric measurements, age, and years since menopause, were body weight and years since menopause (R2 between 0.07 and 0.20, p &lt; 0.001). Risk and protective factors for osteoporosis were analyzed as indicator variables by multiple regression and corrected for confounding by age, years since menopause, and body weight. Significantly lower BMD at the hip was found in participants with impaired mobility (-5%) and users of loop diuretics (-5%). Use of thiazide(like) diuretics did not influence BMD significantly at any site. Users of oral corticosteroids had a significantly lower BMD at the hip and the distal radius (range -9.1 to -24.3%). Participants with a history of Colles' fracture (n = 56) had a significantly lower BMD at the other radius (-12.9%). The mean calcium intake from dairy products was high (mean 921 mg/day), only 11% having an intake below 500 mg. A relation of calcium intake with BMD could not be detected at any measurement site. We conclude that BMD cannot be adequately predicted in elderly women. Risk factors for low BMD in the elderly are low body weight, high number of years since menopause, impaired mobility, and use of loop diuretics and oral corticosteroids. Calcium intake was not a risk factor in this study, but the number of individuals on a low calcium intake was small.

Bibliography

Ooms, M. E., Lips, P., van Lingen, A., & Valkenburg, H. A. (1993). Determinants of bone mineral density and risk factors for osteoporosis in healthy elderly women. Journal of Bone and Mineral Research, 8(6), 669â675.

Authors 4

Marcel E. Ooms (first)
Paul Lips (additional)
Arthur van Lingen (additional)
Hans A. Valkenburg (additional)

References 33 Referenced 98

10.1136/bmj.298.6678.924 / Br Med J / Determinants of bone density in normal women: Risk factors for future osteoporosis? by Stevenson (1989)
10.1007/BF02556017 / Calcif Tissue Int / Familial resemblance of radial bone mass between premenopausal mothers and their college-age daughters by Tylavsky (1989)
10.1007/BF02555106 / Calcif Tissue Int / Is postmenopausal bone loss an age-related phenomenon? by Thomsen (1986)
10.1172/JCI110667 / J Clin Invest / Changes in bone mineral density of the proximal femur and spine with aging by Riggs (1982)
10.1210/jcem-70-1-83 / J Clin Endocrinol Metab / The relative contributions of age and years since menopause to postmenopausal bone loss by Nordin (1990)
10.1002/jbmr.5650020605 / J Bone Miner Res / Total bone calcium in normal women: Effect of age and menopause status by Gallagher (1987)
10.1016/0169-6009(88)90003-7 / Bone Miner / Accelerated vertebral bone loss in relation to the menopause: A cross-sectional study on lumbar bone density in 286 women of 46 to 55 years of age by Elders (1988)
10.7326/0003-4819-112-2-96 / Ann Intern Med / Predictors of bone mass in perimenopausal women by Slemenda (1990)
10.1210/jcem-66-6-1247 / J Clin Endocrinol Metab / The effects of race and body habitus on bone mineral density of the radius, hip and spine in premenopausal women by Liel (1988)
10.1007/BF02409405 / Calcif Tissue Int / Normalisation of bone mineral content to height, weight and lean body mass: Implications for clinical use by Christensen (1981)
10.1016/0169-6009(89)90085-8 / Bone Miner / Perimenopausal bone mass and risk factors by Elders (1989)
10.1016/0169-6009(91)90041-W / Bone Miner / Bone mineral density and physical activity in 50–60 year old women by Cheng (1991)
10.1136/bmj.297.6661.1443 / Br Med J / Physical activity, muscle strength, and calcium intake in fracture of the proximal femur in Britain by Cooper (1988)
10.1136/bmj.297.6661.1441 / Br Med J / Physical activity and calcium intake in fracture of the proximal femur in Hong Kong by Lau (1988)
10.1093/ajcn/46.6.1005 / Am J Clin Nutr / Determinants of vitamin D status in patients with hip fracture and in elderly control subjects by Lips (1987)
{'key': '2024013113122634700_bib16', 'first-page': '1086', 'volume-title': 'Osteoporosis, 1990', 'author': 'Lips', 'year': '1990'} / Osteoporosis, 1990 by Lips (1990)
10.1136/jcp.25.6.512 / J Clin Pathol / The relation of total body potassium to height, weight and age in normal adults by Boddy (1972)
10.1016/0169-6009(90)90099-2 / Bone Miner / Lower mobility and markers of bone resorption in the elderly by Lips (1990)
{'key': '2024013113122634700_bib19', 'author': 'van Hemert', 'year': '1989'} by van Hemert (1989)
10.1016/8756-3282(87)90062-7 / Bone / Obesity and postmenopausal bone loss: The influence of obesity on vertebral density and bone turnover in postmenopausal women by Ribot (1988)
10.1111/j.1532-5415.1990.tb01381.x / J Am Geriatr Soc / Osteoporosis. New insights from bone densitometry by Need (1990)
10.1007/BF03187468 / Osteoporosis Int / Bone mineral density of the hip measured with dual-energy x-ray absorptiometry in normal elderly women and patients with hip fracture by Duboeuf (1991)
10.1016/0169-6009(91)90079-F / Bone Miner / Biochemical parameters of bone turnover during ten days of bed rest and subsequent mobilization by van der Wiel (1991)
10.1093/ageing/16.3.133 / Age Ageing / Postural stability and Colles' fracture by Crilly (1987)
10.1007/BF02555919 / Calcif Tissue Int / Calcium intake and bone mass: A quantitative review of the evidence by Cumming (1990)
10.1093/ajcn/36.5.986 / Am J Clin Nutgr / Calcium nutrition and bone health in the elderly by Heaney (1982)
10.3109/00365598109179613 / Scand J Urol Nephrol / Calcium and magnesium metabolism during long term treatment with thiazides by Ljunghall (1981)
10.1136/bmj.301.6764.1303 / Br Med J / Effect of thiazide on rates of bone mineral loss: A longitudinal study by Wasnich (1990)
10.1056/NEJM199002013220502 / N Engl J Med / Thiazide diuretic agents and the incidence of hip fracture by LaCroix (1990)
10.1016/S0002-9378(85)80035-1 / Am J Obstet Gynecol / Thiazide diuretics and bone mineral content in postmenopausal women by Adland-Davenport (1985)
10.1001/jama.1991.03460030076032 / JAMA / Thiazide diuretics and the risk of hip fracture by Felson (1991)
10.1111/j.1365-2265.1989.tb03730.x / Clin Endocrinol (Oxf) / Pathogenesis and treatment of steroid osteoporosis by Reid (1989)
10.1210/jcem-67-4-644 / J Clin Endocrinol Metab / The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects by Lips (1988)

Dates

Type	When
Created	15 years, 7 months ago (Feb. 3, 2010, 11:49 a.m.)
Deposited	1 year, 5 months ago (March 13, 2024, 10:56 a.m.)
Indexed	1 week, 5 days ago (Aug. 23, 2025, 9:12 p.m.)
Issued	32 years, 3 months ago (June 1, 1993)
Published	32 years, 3 months ago (June 1, 1993)
Published Online	32 years, 3 months ago (June 1, 1993)
Published Print	32 years, 3 months ago (June 1, 1993)

Funders 1

Praeventiefonds, The Hague

BibTeX

@article{Ooms_1993, title={Determinants of bone mineral density and risk factors for osteoporosis in healthy elderly women}, volume={8}, ISSN={1523-4681}, url={http://dx.doi.org/10.1002/jbmr.5650080604}, DOI={10.1002/jbmr.5650080604}, number={6}, journal={Journal of Bone and Mineral Research}, publisher={Oxford University Press (OUP)}, author={Ooms, Marcel E. and Lips, Paul and van Lingen, Arthur and Valkenburg, Hans A.}, year={1993}, month=jun, pages={669–675} }

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