DOI: 10.1002/jbmr.5650050105. Alteration of Vitamin D metabolism in mexican-Americans

Alteration of Vitamin D metabolism in mexican-Americans

10.1002/jbmr.5650050105

Crossref journal-article

Oxford University Press (OUP)

Journal of Bone and Mineral Research (286)

Abstract

Abstract Studies were performed to investigate vitamin D metabolism in Mexican-Americans. Groups of 15 whites and 16 Mexican-Americans ranging in age from 18 to 41 years were evaluated. All of them were within 25% of their ideal body weight. Each of them was admitted to the Clinical Research Center of the University of Texas Health Science Center and placed on a daily diet estimated to contain 400 mg calcium and 900 mg phosphate. It was found that whereas serum vitamin D (1.8 ± 0.5 versus 7.6 ± 1.3 ng/ml, P &lt; 0.001) and serum 25-hydroxyvitamin D (9 ± 1 versus 17 ± 2 ng/ml, P &lt; 0.01) were significantly lower and serum 1,25-dihydroxyvitamin D (37 ± 2 versus 28 ± 2 pg/ml, P &lt; 0.001) was significantly higher in the Mexican-Americans than in the whites, serum calcium (9.1 ± 0.1 versus 9.2 ± 0.1 mg/dl), magnesium (1.84 ± 0.07 versus 1.80 ± 0.07 mEq/liter), and Gla protein (19 ± 3 versus 21 ± 2 ng/ml) were not different in the two groups. Urinary calcium (144 ± 14 versus 124 ± 16 mg/day), phosphate (672 ± 51 versus 683 ± 44 mg/ day), sodium (110 Ω 8 versus 99 ± 9 mEq/day), potassium (43 ± 4 versus 49 ± 3 mEq/day), and magnesium (7.3 ± 0.7 versus 7.7 ± 0.5 mEq/day) and creatinine clearance (173 ± 14 versus 154 ± 7 liters/day) were not different in the two groups. Serum immunoreactive PTH (390 ± 25 versus 299 ± 21 pg/ml, P &lt; 0.02) was significantly higher in the Mexican-Americans than in the whites and urinary cyclic AMP (2.64 Ω 0.27 versus 2.59 ± 0.39 nM/dl GF) was not different in the two groups. The results indicate that Mexican-Americans are depleted of vitamin D and, as a result, have low serum 25-hydroxyvitamin D and compensatory increases in serum immunoreactive PTH and 1, 25-dihydroxyvitamin D. The depletion of vitamin D in Mexican-Americans is attributed to increased skin pigment

Bibliography

Reasner, C. A., Dunn, J. F., Fetchick, D. A., Mundy, G. R., Liel, Y., Hollis, B. W., Shary, J., Bell, N. H., & Epstein, S. (1990). Alteration of Vitamin D metabolism in mexican-Americans. Journal of Bone and Mineral Research, 5(1), 13â17.

Authors 9

Charles A. Reasner (first)
James F. Dunn (additional)
Diane A. Fetchick (additional)
Gregory R. Mundy (additional)
Yair Liel (additional)
Bruce W. Hollis (additional)
Judith Shary (additional)
Norman H. Bell (additional)
Sol Epstein (additional)

References 36 Referenced 30

10.2105/AJPH.76.8.1020 / Am J Public Health / Risk of postmenopausal hip fracture in Mexican-American women by Bauer (1986)
10.1001/archinte.1987.00370080073015 / Arch Intern Med / Low risk of vertebral fracture in Mexican American women by Bauer (1987)
10.2106/00004623-196042010-00005 / J Bone Joint Surg / Densities of bones of white and Negro skeletons by Trotter (1960)
10.1016/0026-0495(77)90052-X / Metabolism / Comparative skeletal mass and radial bone mineral content in black and white women by Cohn (1977)
10.1016/S0022-3476(72)80008-8 / J Pediatr / Advanced skeletal development in low-income Negro children by Garn (1972)
{'key': '2024012712365452600_bib6', 'first-page': '168', 'article-title': 'Anthropometric differences between black and white preschool children', 'volume': '126', 'author': 'Owen', 'year': '1973', 'journal-title': 'Am J Dis Child'} / Am J Dis Child / Anthropometric differences between black and white preschool children by Owen (1973)
{'key': '2024012712365452600_bib7', 'first-page': '164', 'article-title': 'Tendency toward greater stature in American black children', 'volume': '126', 'author': 'Garn', 'year': '1973', 'journal-title': 'Am J Dis Child'} / Am J Dis Child / Tendency toward greater stature in American black children by Garn (1973)
10.1210/jcem-66-6-1247 / J Clin Endocrinol Metab / The effects of race and body habitus on bone mineral density of the radius, hip and spine in premenopausal women by Liel (1988)
{'key': '2024012712365452600_bib9', 'first-page': '1374', 'article-title': 'Race and sex differences in hip fracture incidence', 'volume': '74', 'author': 'Farmer', 'year': '1984', 'journal-title': 'Am J Physiol'} / Am J Physiol / Race and sex differences in hip fracture incidence by Farmer (1984)
10.2105/AJPH.78.11.1482 / Am J Public Health / Decreased incidence of hip fractures in hispanics, Asians, and blacks: California hospital discharge data by Silverman (1988)
10.1172/JCI111995 / J Clin Invest / Evidence for alteration of the vitamin D-endocrine system in blacks by Bell (1985)
10.1002/jbmr.5650010203 / J Bone Min Res / Evidence that obesity does not influence the vitamin D-endocrine system in blacks by Epstein (1988)
{'key': '2024012712365452600_bib13', 'first-page': '49', 'article-title': 'Direct microdetermination of calcium', 'volume': '46', 'author': 'Baginsky', 'year': '1973', 'journal-title': 'Clin Chim Acta'} / Clin Chim Acta / Direct microdetermination of calcium by Baginsky (1973)
10.1016/S0021-9258(18)84756-1 / J Biol Chem / The colorimetric determination of phosphorus by Fiske (1925)
10.1016/0009-8981(71)90467-0 / Clin Chem Acta / Eine mikromethode zur kreatinin bestimmung by Bartels (1971)
{'key': '2024012712365452600_bib16', 'first-page': '662', 'article-title': 'Colorimetric determination with bound “Calgamite” of magnesium in human blood serum', 'volume': '17', 'author': 'Gindler', 'year': '1971', 'journal-title': 'Clin Chem'} / Clin Chem / Colorimetric determination with bound “Calgamite” of magnesium in human blood serum by Gindler (1971)
10.1007/BF02555135 / Calcif Tissue Int / Low circulating vitamin D in obesity by Liel (1988)
10.1016/S0378-4347(00)84566-1 / J Chromatogr / Solid phase extraction of vitamin D and its major metabolites from human plasma by Hollis (1985)
10.1016/S0039-128X(81)90137-9 / Steroids / Vitamin D in plasma: Quantitation by a nortequilibrium ligand binding assay by Hollis (1981)
10.1016/S0076-6879(86)23020-7 / Methods Enzymol / Quantitation of vitamin D compounds in human milk by Hollis (1986)
10.1210/jcem-38-6-1046 / J Clin Endocrinol Metab / A rapid assay for 25-OH-vitamin D3 without preparative chromatography by Belsey (1974)
10.1210/jcem-58-1-91 / J Clin Endocrinol Metab / A micro-assay for 1, 25-dihydroxyvitamin D not requiring high performance liquid chromatography: Application to clinical studies by Reinhardt (1984)
10.1172/JCI111971 / J Clin Invest / Evidence for alteration of the vitamin D-endocrine system in obese subjects by Bell (1985)
10.1016/S0140-6736(84)90360-X / Lancet / Differences in serum bone Gla protein with age and sex by Epstein (1984)
10.1073/pnas.67.1.305 / Proc Natl Acad Sci USA / A protein binding assay for adenosine 3′, 5′-monophosphate by Gilman (1970)
10.1172/JCI108831 / J Clin Invest / Nephrogenous cyclic adenosine monophosphate as a parathyroid function test by Broadus (1977)
10.1016/S0140-6736(82)90214-8 / Lancet / Increased skin pigment reduces the capacity of the skin to synthesize vitamin D by Clemens (1982)
10.2337/diab.33.1.86 / Diabetes / Prevalence of diabetes in Mexican Americans: Relationship to percent of gene pool derived from Native American Sources by Gardner (1984)
{'key': '2024012712365452600_bib29', 'first-page': '315', 'article-title': 'Parathyroid hormone levels in obesity: Effects of intestinal bypass surgery', 'volume': '1', 'author': 'Atkinson', 'year': '1978', 'journal-title': 'Min Electrolyte Metab'} / Min Electrolyte Metab / Parathyroid hormone levels in obesity: Effects of intestinal bypass surgery by Atkinson (1978)
10.7326/0003-4819-86-3-289 / Ann Intern Med / Abnormalities of circulating 25-OH vitamin D after jejunal bypass for obesity: Evidence of an adaptive response by Teitelbaum (1977)
10.1002/jbmr.5650030503 / J Bone Min Res / Evidence of a probably role for 25-hydroxyvitamin D in the regulation of human calcium metabolism by Bell (1988)
{'key': '2024012712365452600_bib32', 'first-page': '38', 'volume-title': 'Osteoporosis', 'author': 'Saville', 'year': '1970'} / Osteoporosis by Saville (1970)
10.1002/jbmr.5650010411 / J Bone Min Res / Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1–34) and 1, 25-dihydroxyvitamin D by Slovik (1986)
10.1073/pnas.84.7.2024 / Proc Natl Acad Sci USA / Modulation of type ß transforming growth factor activity in bone cultures by osteotropic hormones by Pfeilschifter (1987)
10.1172/JCI113885 / J Clin Invest / Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures by Canalis (1989)
10.1056/NEJM198812293192603 / N Engl J Med / Diminished rates of bone formation in normal black adults by Weinstein (1988)

Dates

Type	When
Created	15 years, 6 months ago (Feb. 24, 2010, 2:24 p.m.)
Deposited	1 year, 5 months ago (March 13, 2024, 10:50 a.m.)
Indexed	1 year, 2 months ago (June 13, 2024, 7:30 p.m.)
Issued	35 years, 8 months ago (Jan. 1, 1990)
Published	35 years, 8 months ago (Jan. 1, 1990)
Published Online	35 years, 8 months ago (Jan. 1, 1990)
Published Print	35 years, 8 months ago (Jan. 1, 1990)

Funders 2

Clinical Research Center at the Audie L. Murphy VA Medical Center
Awards1
1. AR 36066, HD 22542, and M01 RR 01346()
General Clinical Research Center at the Medical University of South Carolina
Awards1
1. M01 RR 01070

BibTeX

@article{Reasner_1990, title={Alteration of Vitamin D metabolism in mexican-Americans}, volume={5}, ISSN={1523-4681}, url={http://dx.doi.org/10.1002/jbmr.5650050105}, DOI={10.1002/jbmr.5650050105}, number={1}, journal={Journal of Bone and Mineral Research}, publisher={Oxford University Press (OUP)}, author={Reasner, Charles A. and Dunn, James F. and Fetchick, Diane A. and Mundy, Gregory R. and Liel, Yair and Hollis, Bruce W. and Shary, Judith and Bell, Norman H. and Epstein, Sol}, year={1990}, month=jan, pages={13–17} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        6,
        13
      ]
    ],
    "date-time": "2024-06-13T23:30:59Z",
    "timestamp": 1718321459858
  },
  "reference-count": 36,
  "publisher": "Oxford University Press (OUP)",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1990,
            1,
            1
          ]
        ],
        "date-time": "1990-01-01T00:00:00Z",
        "timestamp": 631152000000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model"
    }
  ],
  "funder": [
    {
      "name": "Clinical Research Center at the Audie L. Murphy VA Medical Center",
      "award": [
        "AR 36066, HD 22542, and M01 RR 01346()"
      ]
    },
    {
      "name": "General Clinical Research Center at the Medical University of South Carolina",
      "award": [
        "M01 RR 01070"
      ]
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1990,
        1,
        1
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title>\n               <jats:p>Studies were performed to investigate vitamin D metabolism in Mexican-Americans. Groups of 15 whites and 16 Mexican-Americans ranging in age from 18 to 41 years were evaluated. All of them were within 25% of their ideal body weight. Each of them was admitted to the Clinical Research Center of the University of Texas Health Science Center and placed on a daily diet estimated to contain 400 mg calcium and 900 mg phosphate. It was found that whereas serum vitamin D (1.8 \u00b1 0.5 versus 7.6 \u00b1 1.3 ng/ml, P &amp;lt; 0.001) and serum 25-hydroxyvitamin D (9 \u00b1 1 versus 17 \u00b1 2 ng/ml, P &amp;lt; 0.01) were significantly lower and serum 1,25-dihydroxyvitamin D (37 \u00b1 2 versus 28 \u00b1 2 pg/ml, P &amp;lt; 0.001) was significantly higher in the Mexican-Americans than in the whites, serum calcium (9.1 \u00b1 0.1 versus 9.2 \u00b1 0.1 mg/dl), magnesium (1.84 \u00b1 0.07 versus 1.80 \u00b1 0.07 mEq/liter), and Gla protein (19 \u00b1 3 versus 21 \u00b1 2 ng/ml) were not different in the two groups. Urinary calcium (144 \u00b1 14 versus 124 \u00b1 16 mg/day), phosphate (672 \u00b1 51 versus 683 \u00b1 44 mg/ day), sodium (110 \u03a9 8 versus 99 \u00b1 9 mEq/day), potassium (43 \u00b1 4 versus 49 \u00b1 3 mEq/day), and magnesium (7.3 \u00b1 0.7 versus 7.7 \u00b1 0.5 mEq/day) and creatinine clearance (173 \u00b1 14 versus 154 \u00b1 7 liters/day) were not different in the two groups. Serum immunoreactive PTH (390 \u00b1 25 versus 299 \u00b1 21 pg/ml, P &amp;lt; 0.02) was significantly higher in the Mexican-Americans than in the whites and urinary cyclic AMP (2.64 \u03a9 0.27 versus 2.59 \u00b1 0.39 nM/dl GF) was not different in the two groups. The results indicate that Mexican-Americans are depleted of vitamin D and, as a result, have low serum 25-hydroxyvitamin D and compensatory increases in serum immunoreactive PTH and 1, 25-dihydroxyvitamin D. The depletion of vitamin D in Mexican-Americans is attributed to increased skin pigment</jats:p>",
  "DOI": "10.1002/jbmr.5650050105",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2010,
        2,
        24
      ]
    ],
    "date-time": "2010-02-24T19:24:45Z",
    "timestamp": 1267039485000
  },
  "page": "13-17",
  "source": "Crossref",
  "is-referenced-by-count": 30,
  "title": "Alteration of Vitamin D metabolism in mexican-Americans",
  "prefix": "10.1093",
  "volume": "5",
  "author": [
    {
      "suffix": "II",
      "given": "Charles A.",
      "family": "Reasner",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Medicine, University of Texas Health Science Center at San Antonio, TX 78284"
        }
      ]
    },
    {
      "given": "James F.",
      "family": "Dunn",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Medicine, University of Texas Health Science Center at San Antonio, TX 78284"
        }
      ]
    },
    {
      "given": "Diane A.",
      "family": "Fetchick",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Medicine, University of Texas Health Science Center at San Antonio, TX 78284"
        }
      ]
    },
    {
      "given": "Gregory R.",
      "family": "Mundy",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Medicine, University of Texas Health Science Center at San Antonio, TX 78284"
        }
      ]
    },
    {
      "given": "Yair",
      "family": "Liel",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Audie L. Murphy Veterans Administration Medical Center, San Antonio, TX 78284"
        }
      ]
    },
    {
      "given": "Bruce W.",
      "family": "Hollis",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Veterans Administration Medical Center, and Departments of Medicine, Pediatrics, and Pharmacology, Medical University of South Carolina, Charleston, SC 29403"
        }
      ]
    },
    {
      "given": "Judith",
      "family": "Shary",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Veterans Administration Medical Center, and Departments of Medicine, Pediatrics, and Pharmacology, Medical University of South Carolina, Charleston, SC 29403"
        }
      ]
    },
    {
      "given": "Norman H.",
      "family": "Bell",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Veterans Administration Medical Center, and Departments of Medicine, Pediatrics, and Pharmacology, Medical University of South Carolina, Charleston, SC 29403"
        }
      ]
    },
    {
      "given": "Sol",
      "family": "Epstein",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Albert Einstein Medical Center, York and Tabor Roads, Philadelphia, PA 55901"
        }
      ]
    }
  ],
  "member": "286",
  "published-online": {
    "date-parts": [
      [
        1990,
        1,
        1
      ]
    ]
  },
  "reference": [
    {
      "key": "2024012712365452600_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "1020",
      "DOI": "10.2105/AJPH.76.8.1020",
      "article-title": "Risk of postmenopausal hip fracture in Mexican-American women",
      "volume": "76",
      "author": "Bauer",
      "year": "1986",
      "journal-title": "Am J Public Health"
    },
    {
      "key": "2024012712365452600_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "1437",
      "DOI": "10.1001/archinte.1987.00370080073015",
      "article-title": "Low risk of vertebral fracture in Mexican American women",
      "volume": "147",
      "author": "Bauer",
      "year": "1987",
      "journal-title": "Arch Intern Med"
    },
    {
      "key": "2024012712365452600_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "50",
      "DOI": "10.2106/00004623-196042010-00005",
      "article-title": "Densities of bones of white and Negro skeletons",
      "volume": "42A",
      "author": "Trotter",
      "year": "1960",
      "journal-title": "J Bone Joint Surg"
    },
    {
      "key": "2024012712365452600_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "171",
      "DOI": "10.1016/0026-0495(77)90052-X",
      "article-title": "Comparative skeletal mass and radial bone mineral content in black and white women",
      "volume": "26",
      "author": "Cohn",
      "year": "1977",
      "journal-title": "Metabolism"
    },
    {
      "key": "2024012712365452600_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "965",
      "DOI": "10.1016/S0022-3476(72)80008-8",
      "article-title": "Advanced skeletal development in low-income Negro children",
      "volume": "80",
      "author": "Garn",
      "year": "1972",
      "journal-title": "J Pediatr"
    },
    {
      "key": "2024012712365452600_bib6",
      "first-page": "168",
      "article-title": "Anthropometric differences between black and white preschool children",
      "volume": "126",
      "author": "Owen",
      "year": "1973",
      "journal-title": "Am J Dis Child"
    },
    {
      "key": "2024012712365452600_bib7",
      "first-page": "164",
      "article-title": "Tendency toward greater stature in American black children",
      "volume": "126",
      "author": "Garn",
      "year": "1973",
      "journal-title": "Am J Dis Child"
    },
    {
      "key": "2024012712365452600_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "1247",
      "DOI": "10.1210/jcem-66-6-1247",
      "article-title": "The effects of race and body habitus on bone mineral density of the radius, hip and spine in premenopausal women",
      "volume": "66",
      "author": "Liel",
      "year": "1988",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "2024012712365452600_bib9",
      "first-page": "1374",
      "article-title": "Race and sex differences in hip fracture incidence",
      "volume": "74",
      "author": "Farmer",
      "year": "1984",
      "journal-title": "Am J Physiol"
    },
    {
      "key": "2024012712365452600_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "1482",
      "DOI": "10.2105/AJPH.78.11.1482",
      "article-title": "Decreased incidence of hip fractures in hispanics, Asians, and blacks: California hospital discharge data",
      "volume": "78",
      "author": "Silverman",
      "year": "1988",
      "journal-title": "Am J Public Health"
    },
    {
      "key": "2024012712365452600_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "470",
      "DOI": "10.1172/JCI111995",
      "article-title": "Evidence for alteration of the vitamin D-endocrine system in blacks",
      "volume": "76",
      "author": "Bell",
      "year": "1985",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "2024012712365452600_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "181",
      "DOI": "10.1002/jbmr.5650010203",
      "article-title": "Evidence that obesity does not influence the vitamin D-endocrine system in blacks",
      "volume": "1",
      "author": "Epstein",
      "year": "1988",
      "journal-title": "J Bone Min Res"
    },
    {
      "key": "2024012712365452600_bib13",
      "first-page": "49",
      "article-title": "Direct microdetermination of calcium",
      "volume": "46",
      "author": "Baginsky",
      "year": "1973",
      "journal-title": "Clin Chim Acta"
    },
    {
      "key": "2024012712365452600_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "375",
      "DOI": "10.1016/S0021-9258(18)84756-1",
      "article-title": "The colorimetric determination of phosphorus",
      "volume": "66",
      "author": "Fiske",
      "year": "1925",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "2024012712365452600_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1016/0009-8981(71)90467-0",
      "article-title": "Eine mikromethode zur kreatinin bestimmung",
      "volume": "32",
      "author": "Bartels",
      "year": "1971",
      "journal-title": "Clin Chem Acta"
    },
    {
      "key": "2024012712365452600_bib16",
      "first-page": "662",
      "article-title": "Colorimetric determination with bound \u201cCalgamite\u201d of magnesium in human blood serum",
      "volume": "17",
      "author": "Gindler",
      "year": "1971",
      "journal-title": "Clin Chem"
    },
    {
      "key": "2024012712365452600_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "199",
      "DOI": "10.1007/BF02555135",
      "article-title": "Low circulating vitamin D in obesity",
      "volume": "43",
      "author": "Liel",
      "year": "1988",
      "journal-title": "Calcif Tissue Int"
    },
    {
      "key": "2024012712365452600_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "43",
      "DOI": "10.1016/S0378-4347(00)84566-1",
      "article-title": "Solid phase extraction of vitamin D and its major metabolites from human plasma",
      "volume": "343",
      "author": "Hollis",
      "year": "1985",
      "journal-title": "J Chromatogr"
    },
    {
      "key": "2024012712365452600_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "609",
      "DOI": "10.1016/S0039-128X(81)90137-9",
      "article-title": "Vitamin D in plasma: Quantitation by a nortequilibrium ligand binding assay",
      "volume": "37",
      "author": "Hollis",
      "year": "1981",
      "journal-title": "Steroids"
    },
    {
      "key": "2024012712365452600_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "167",
      "DOI": "10.1016/S0076-6879(86)23020-7",
      "article-title": "Quantitation of vitamin D compounds in human milk",
      "volume": "123",
      "author": "Hollis",
      "year": "1986",
      "journal-title": "Methods Enzymol"
    },
    {
      "key": "2024012712365452600_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "1046",
      "DOI": "10.1210/jcem-38-6-1046",
      "article-title": "A rapid assay for 25-OH-vitamin D3 without preparative chromatography",
      "volume": "38",
      "author": "Belsey",
      "year": "1974",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "2024012712365452600_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "91",
      "DOI": "10.1210/jcem-58-1-91",
      "article-title": "A micro-assay for 1, 25-dihydroxyvitamin D not requiring high performance liquid chromatography: Application to clinical studies",
      "volume": "58",
      "author": "Reinhardt",
      "year": "1984",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "2024012712365452600_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "370",
      "DOI": "10.1172/JCI111971",
      "article-title": "Evidence for alteration of the vitamin D-endocrine system in obese subjects",
      "volume": "76",
      "author": "Bell",
      "year": "1985",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "2024012712365452600_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "307",
      "DOI": "10.1016/S0140-6736(84)90360-X",
      "article-title": "Differences in serum bone Gla protein with age and sex",
      "volume": "2",
      "author": "Epstein",
      "year": "1984",
      "journal-title": "Lancet"
    },
    {
      "key": "2024012712365452600_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "305",
      "DOI": "10.1073/pnas.67.1.305",
      "article-title": "A protein binding assay for adenosine 3\u2032, 5\u2032-monophosphate",
      "volume": "67",
      "author": "Gilman",
      "year": "1970",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "2024012712365452600_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "771",
      "DOI": "10.1172/JCI108831",
      "article-title": "Nephrogenous cyclic adenosine monophosphate as a parathyroid function test",
      "volume": "60",
      "author": "Broadus",
      "year": "1977",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "2024012712365452600_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "74",
      "DOI": "10.1016/S0140-6736(82)90214-8",
      "article-title": "Increased skin pigment reduces the capacity of the skin to synthesize vitamin D",
      "volume": "1",
      "author": "Clemens",
      "year": "1982",
      "journal-title": "Lancet"
    },
    {
      "key": "2024012712365452600_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "86",
      "DOI": "10.2337/diab.33.1.86",
      "article-title": "Prevalence of diabetes in Mexican Americans: Relationship to percent of gene pool derived from Native American Sources",
      "volume": "33",
      "author": "Gardner",
      "year": "1984",
      "journal-title": "Diabetes"
    },
    {
      "key": "2024012712365452600_bib29",
      "first-page": "315",
      "article-title": "Parathyroid hormone levels in obesity: Effects of intestinal bypass surgery",
      "volume": "1",
      "author": "Atkinson",
      "year": "1978",
      "journal-title": "Min Electrolyte Metab"
    },
    {
      "key": "2024012712365452600_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "289",
      "DOI": "10.7326/0003-4819-86-3-289",
      "article-title": "Abnormalities of circulating 25-OH vitamin D after jejunal bypass for obesity: Evidence of an adaptive response",
      "volume": "86",
      "author": "Teitelbaum",
      "year": "1977",
      "journal-title": "Ann Intern Med"
    },
    {
      "key": "2024012712365452600_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "489",
      "DOI": "10.1002/jbmr.5650030503",
      "article-title": "Evidence of a probably role for 25-hydroxyvitamin D in the regulation of human calcium metabolism",
      "volume": "3",
      "author": "Bell",
      "year": "1988",
      "journal-title": "J Bone Min Res"
    },
    {
      "key": "2024012712365452600_bib32",
      "first-page": "38",
      "volume-title": "Osteoporosis",
      "author": "Saville",
      "year": "1970"
    },
    {
      "key": "2024012712365452600_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "377",
      "DOI": "10.1002/jbmr.5650010411",
      "article-title": "Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1\u201334) and 1, 25-dihydroxyvitamin D",
      "volume": "1",
      "author": "Slovik",
      "year": "1986",
      "journal-title": "J Bone Min Res"
    },
    {
      "key": "2024012712365452600_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "2024",
      "DOI": "10.1073/pnas.84.7.2024",
      "article-title": "Modulation of type \u00df transforming growth factor activity in bone cultures by osteotropic hormones",
      "volume": "84",
      "author": "Pfeilschifter",
      "year": "1987",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "2024012712365452600_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "60",
      "DOI": "10.1172/JCI113885",
      "article-title": "Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures",
      "volume": "83",
      "author": "Canalis",
      "year": "1989",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "2024012712365452600_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "1698",
      "DOI": "10.1056/NEJM198812293192603",
      "article-title": "Diminished rates of bone formation in normal black adults",
      "volume": "319",
      "author": "Weinstein",
      "year": "1988",
      "journal-title": "N Engl J Med"
    }
  ],
  "container-title": "Journal of Bone and Mineral Research",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjbmr.5650050105",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://academic.oup.com/jbmr/article-pdf/5/1/13/56431260/5650050105.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "https://academic.oup.com/jbmr/article-pdf/5/1/13/56431260/5650050105.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        3,
        13
      ]
    ],
    "date-time": "2024-03-13T14:50:28Z",
    "timestamp": 1710341428000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://academic.oup.com/jbmr/article/5/1/13-17/7502058"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1990,
        1,
        1
      ]
    ]
  },
  "references-count": 36,
  "journal-issue": {
    "issue": "1",
    "published-online": {
      "date-parts": [
        [
          1990,
          1,
          1
        ]
      ]
    },
    "published-print": {
      "date-parts": [
        [
          1990,
          1,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1002/jbmr.5650050105",
  "relation": {},
  "ISSN": [
    "0884-0431",
    "1523-4681"
  ],
  "subject": [],
  "published-other": {
    "date-parts": [
      [
        1990,
        1,
        1
      ]
    ]
  },
  "published": {
    "date-parts": [
      [
        1990,
        1,
        1
      ]
    ]
  }
}