DOI: 10.1002/jbmr.5650030309. Forearm bone loss in hemiplegia: A model for the study of immobilization osteoporosis

Forearm bone loss in hemiplegia: A model for the study of immobilization osteoporosis

10.1002/jbmr.5650030309

Crossref journal-article

Oxford University Press (OUP)

Journal of Bone and Mineral Research (286)

Abstract

Abstract Hemiplegia is associated with excessive bone loss in the paralyzed arm. The forearm bone mineral content was measured at a proximal cortical site and a distal trabecular site of both the normal and hemiplegic arms in 74 patients with hemiplegia. By comparing the ratios of bone mineral content in the two arms, the effect of immobilization could be quantitated independently of the large population variance in bone mineral content. Bone loss, estimated from this single comparison of bone mineral content in the normal and hemiplegic arms, at the trabecular and cortical sites was positively correlated with the duration of stroke and negatively correlated with reduction in forearm function. At the trabecular site females had a proportionately greater bone loss than males, indicating an interaction between gender and immobilization associated bone loss at this site. The regression line of excess bone loss in the hemiplegic limb against time had a negative slope of 1.3% and 1.5% a year of the starting value for the trabecular and cortical sites, respectively, over the 15 years studied. This study indicates that a reduction in function is associated with significant bone loss occurring over prolonged periods that may account, at least in part, for the significant osteoporosis seen in elderly people and in subjects with conditions resulting in reduced mobility such as arthritis, obstructive airways disease, and neurological disease.

Bibliography

Dr. Prince, R. L., Price, R. I., & Ho, S. (1988). Forearm bone loss in hemiplegia: A model for the study of immobilization osteoporosis. Journal of Bone and Mineral Research, 3(3), 305â310.

Authors 3

R.L. Dr. Prince (first)
R.I. Price (additional)
S. Ho (additional)

References 24 Referenced 76

10.1016/0026-0495(70)90032-6 / Metabolism / Effect of prolonged bed rest on bone mineral by Donaldson (1970)
10.2214/ajr.100.3.503 / Am J Roentgenol / Bone demineralization of foot and hand of Gemini-Titan IV, V and VII astronauts during orbital flight by Mack (1967)
10.1302/0301-620X.34B2.256 / J Bone Joint Surg / The osteoporosis of immobilisation in recumbency by Stevenson (1952)
10.1111/j.1532-5415.1967.tb05337.x / J Am Geriatr Soc / Unilateral osteoporosis in longstanding hemiplegia in the elderly by Hodkinson (1967)
10.1136/pgmj.55.642.264 / Postgrad Med J / Hip fracture after hemiplegia by Mulley (1979)
{'key': '2024012712221760100_bib6', 'first-page': '687', 'article-title': 'The fractured hip in hemiplegic patients', 'volume': '12', 'author': 'Peszczynski', 'year': '1957', 'journal-title': 'Geriatr'} / Geriatr / The fractured hip in hemiplegic patients by Peszczynski (1957)
{'key': '2024012712221760100_bib7', 'first-page': '128', 'article-title': 'Quantitative in-vivo determination of bone mineral using computerized roentgenographic densitometry', 'volume': '6', 'author': 'Price', 'year': '1983', 'journal-title': 'Australas Phys Eng Sci Med'} / Australas Phys Eng Sci Med / Quantitative in-vivo determination of bone mineral using computerized roentgenographic densitometry by Price (1983)
10.1007/BF02546396 / Calcif Tiss Res / The distribution of cortical and trabecular bone mass along the lengths of the radius and ulna and the implications of in-vitro bone mass measurements by Schlenker (1976)
10.1093/ptj/65.2.175 / Phys Ther / Investigation of a new motor assessment scale for stroke patients by Carr (1985)
{'key': '2024012712221760100_bib10', 'first-page': '1', 'volume-title': 'SPSS Update 7–9', 'author': 'Hull', 'year': '1981'} / SPSS Update 7–9 by Hull (1981)
10.1007/BF02553711 / Calcif Tissue Int / Regulation of bone mass by mechanical strain magnitude by Rubin (1985)
{'key': '2024012712221760100_bib12', 'first-page': '441', 'article-title': 'Increased bone formation and decreased bone resorption in fetal mouse calvaria as a result of intermittent compressive force in vitro', 'volume': '6', 'author': 'Klein-Nulend', 'year': '1987', 'journal-title': 'BAM'} / BAM / Increased bone formation and decreased bone resorption in fetal mouse calvaria as a result of intermittent compressive force in vitro by Klein-Nulend (1987)
10.1172/JCI108518 / J Clin Invest / Age and activity effects on rate of bone mineral loss by Smith (1976)
10.1172/JCI110039 / J Clin Invest / Differential changes in bone mineral density of the appendicular and axial skeleton with aging. Relationship to spinal osteoporosis by Riggs (1981)
10.1007/BF02547214 / Calcif Tiss Res / Quantitative histological data on disuse osteoporosis by Minaire (1974)
10.1172/JCI106751 / J Clin Invest / The effect of supplemental oral phosphate on the bone mineral changes during prolonged bed rest by Hulley (1971)
{'key': '2024012712221760100_bib17', 'first-page': '392', 'article-title': 'Effect of paralysis of one lower extremity on bone growth', 'volume': '31', 'author': 'Gullickson', 'year': '1950', 'journal-title': 'Arch Phys Med'} / Arch Phys Med / Effect of paralysis of one lower extremity on bone growth by Gullickson (1950)
10.1111/j.1445-5994.1983.tb04537.x / Aust NZ J Med / Hypercalcaemia in association with renal failure: the role of immobilisation by Prince (1983)
10.1056/NEJM198205133061903 / N Engl J Med / Calcium homeostasis in immobilization: an example of resorptive hypercalciuria by Stewart (1982)
10.1016/S0140-6736(70)91520-5 / Lancet / Relation between bone mass and muscle weight by Doyle (1970)
{'key': '2024012712221760100_bib21', 'first-page': '147', 'article-title': 'Influence of weight-bearing and muscle contraction on disuse osteoporosis', 'volume': '42', 'author': 'Abramson', 'year': '1961', 'journal-title': 'Arch Phys Med Rehabil'} / Arch Phys Med Rehabil / Influence of weight-bearing and muscle contraction on disuse osteoporosis by Abramson (1961)
10.2106/00004623-197759020-00012 / J Bone Joint Surg / Humeral hypertrophy in response to exercise by Jones (1977)
10.1152/jappl.1966.21.3.1013 / J Appl Physiol / Effect of prolonged bedrest on urinary calcium output by Issekutz (1966)
10.1056/NEJM198408023110501 / N Engl J Med / Bone mineral content of amenorrheic and eumenorrheic athletes by Drinkwater (1984)

Dates

Type	When
Created	15 years, 7 months ago (Feb. 3, 2010, 1:13 p.m.)
Deposited	1 year, 5 months ago (March 13, 2024, 10:49 a.m.)
Indexed	11 months, 3 weeks ago (Sept. 12, 2024, 12:32 a.m.)
Issued	37 years, 3 months ago (June 1, 1988)
Published	37 years, 3 months ago (June 1, 1988)
Published Online	37 years, 3 months ago (June 1, 1988)
Published Print	37 years, 3 months ago (June 1, 1988)

Funders 1

Sir Charles Gairdner Hospital Research Foundation

BibTeX

@article{Dr_Prince_1988, title={Forearm bone loss in hemiplegia: A model for the study of immobilization osteoporosis}, volume={3}, ISSN={1523-4681}, url={http://dx.doi.org/10.1002/jbmr.5650030309}, DOI={10.1002/jbmr.5650030309}, number={3}, journal={Journal of Bone and Mineral Research}, publisher={Oxford University Press (OUP)}, author={Dr. Prince, R.L. and Price, R.I. and Ho, S.}, year={1988}, month=jun, pages={305–310} }

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