DOI: 10.1002/jbm.820070204. Resorption rate, route of elimination, and ultrastructure of the implant site of polylactic acid in the abdominal wall of the rat

Resorption rate, route of elimination, and ultrastructure of the implant site of polylactic acid in the abdominal wall of the rat

10.1002/jbm.820070204

Crossref journal-article

Wiley

Journal of Biomedical Materials Research (311)

Abstract

AbstractThis experiment describes resorption rate, light and electron microscopic appearance of the implant site, and tissue distribution and route of elimination of radioactivity from carbon‐labelled polylactic acid implants. Fifty‐six rats received abdominal implants and were serially sacrificed at 28, 56, 84, 112, 140, 154, and 168 days. Urine and fecal output was measured for radioactivity, along with implant site and several tissues at the time of sacrifice. Tissue distribution of activity was negligible. Resorption rate of the implant was linear with 63.2% remaining after 168 days. Elimination of radioactivity was via respiration, approximately 29.4% by this route. Histologically, the implant was invaded rapidly along septal defects or slowly on broad fronts. Invading cells were characterized either by large double‐walled vacuoles or by large accumulations of mitochondria and microvesicles adjacent to the implant surface. The long duration of this type of implant may be an important consideration in surgical applications.

Bibliography

Brady, J. M., Cutright, D. E., Miller, R. A., Battistone, G. C., & Hunsuck, E. E. (1973). Resorption rate, route of elimination, and ultrastructure of the implant site of polylactic acid in the abdominal wall of the rat. Journal of Biomedical Materials Research, 7(2), 155â166. Portico.

Authors 5

John M. Brady (first)
Duane E. Cutright (additional)
Robert A. Miller (additional)
Gino C. Battistone (additional)
Ervin E. Hunsuck (additional)

References 3 Referenced 210

10.1016/0030-4220(72)90204-6
{'key': 'e_1_2_1_3_2', 'first-page': '393', 'volume': '29', 'author': 'Cutright D. E.', 'year': '1971', 'journal-title': 'J. Oral Surg.'} / J. Oral Surg. by Cutright D. E. (1971)
10.1002/jbm.820050305

Dates

Type	When
Created	20 years, 8 months ago (Dec. 31, 2004, 9:04 a.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 5:51 a.m.)
Indexed	1 month, 3 weeks ago (July 16, 2025, 9:34 a.m.)
Issued	52 years, 6 months ago (March 1, 1973)
Published	52 years, 6 months ago (March 1, 1973)
Published Online	20 years, 11 months ago (Sept. 13, 2004)
Published Print	52 years, 6 months ago (March 1, 1973)

Funders 0

None

BibTeX

@article{Brady_1973, title={Resorption rate, route of elimination, and ultrastructure of the implant site of polylactic acid in the abdominal wall of the rat}, volume={7}, ISSN={1097-4636}, url={http://dx.doi.org/10.1002/jbm.820070204}, DOI={10.1002/jbm.820070204}, number={2}, journal={Journal of Biomedical Materials Research}, publisher={Wiley}, author={Brady, John M. and Cutright, Duane E. and Miller, Robert A. and Battistone, Gino C. and Hunsuck, Ervin E.}, year={1973}, month=mar, pages={155–166} }

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