DOI: 10.1002/jbm.1237. <i>In situ</i> hydrogelation of photocurable gelatin and drug release

In situ hydrogelation of photocurable gelatin and drug release

10.1002/jbm.1237

Crossref journal-article

Wiley

Journal of Biomedical Materials Research (311)

Abstract

AbstractWe devised an in situ tissue‐adhesive, drug‐release technology based on a photoreactive gelatin, which allows in situ drug‐incorporated gel formation on living tissues and sustained drug release directly on diseased tissues. Styrene‐derivatized gelatins, synthesized by condensation reaction of gelatin with 4‐vinylbenzoic acid, were photopolymerized in the presence of a water‐soluble camphorquinone derivative as a photoinitiator upon visible‐light irradiation to form swollen gels. Using albumin as a drug model, gelation characteristics and drug‐release characteristics easily were manipulated by material variables, formulation variables, and operation variables. Tissue adhesivity of the gel was superior to that of fibrin glue. The biologic response, which was evaluated by intraperitoneal implantation in rats, showed that the gel was biodegraded and biosorbed, without cytotoxicity, within a few months after implantation. An in situ processable tissue‐adhesive local drug release system effectively may be used to help inhibit tumor recurrence. © 2001 Wiley Periodicals, Inc. J Biomed Mater Res 59: 233–245, 2002

Bibliography

Okino, H., Nakayama, Y., Tanaka, M., & Matsuda, T. (2001). In situ hydrogelation of photocurable gelatin and drug release. Journal of Biomedical Materials Research, 59(2), 233â245. Portico.

Authors 4

H. Okino (first)
Y. Nakayama (additional)
M. Tanaka (additional)
T. Matsuda (additional)

References 26 Referenced 101

10.3109/10731197709118662
10.1002/jbm.820290303
10.1016/0142-9612(96)85574-8
{'key': 'e_1_2_7_5_2', 'first-page': '59', 'article-title': 'Prevention of postoperative adhesions in the rat by in situ photopolymerization of bioresorbable hydrogel barriers', 'volume': '83', 'author': 'Hill‐West JL', 'year': '1994', 'journal-title': 'Obstet Gynecol'} / Obstet Gynecol / Prevention of postoperative adhesions in the rat by in situ photopolymerization of bioresorbable hydrogel barriers by Hill‐West JL (1994)
10.1177/096368979900800310 / Cell Transplant / In vitro and in vivo performance of porcine islets encapsulated in interfacially photopolymerized poly(ethylene glycol) diacrylate membranes by Cruise GM (1999)
10.1002/(SICI)1097-4636(200008)51:2<164::AID-JBM4>3.0.CO;2-W
10.1016/0142-9612(93)90194-7
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{'key': 'e_1_2_7_13_2', 'volume-title': 'The Mathematics of diffusion', 'author': 'Crank J.', 'year': '1956'} / The Mathematics of diffusion by Crank J. (1956)
10.1016/S0963-6897(96)00255-2
{'key': 'e_1_2_7_15_2', 'first-page': '488', 'volume-title': 'Encyclopedia of polymer science and engineering', 'author': 'Rose PI', 'year': '1987'} / Encyclopedia of polymer science and engineering by Rose PI (1987)
{'key': 'e_1_2_7_16_2', 'first-page': '172', 'article-title': 'Production of granules with controlled drug release rate', 'volume': '34', 'author': 'Bozzay J', 'year': '1979', 'journal-title': 'Pharmazie'} / Pharmazie / Production of granules with controlled drug release rate by Bozzay J (1979)
10.1016/S0168-3659(99)00129-7
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10.1083/jcb.92.2.485
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10.1016/S0014-5793(97)01475-0

Dates

Type	When
Created	23 years ago (Aug. 25, 2002, 12:13 p.m.)
Deposited	1 year, 10 months ago (Oct. 16, 2023, 8:25 a.m.)
Indexed	2 months ago (July 2, 2025, 8:45 a.m.)
Issued	23 years, 10 months ago (Nov. 2, 2001)
Published	23 years, 10 months ago (Nov. 2, 2001)
Published Online	23 years, 10 months ago (Nov. 2, 2001)
Published Print	23 years, 7 months ago (Feb. 1, 2002)

Funders 0

None

BibTeX

@article{Okino_2001, title={In situ hydrogelation of photocurable gelatin and drug release}, volume={59}, ISSN={1097-4636}, url={http://dx.doi.org/10.1002/jbm.1237}, DOI={10.1002/jbm.1237}, number={2}, journal={Journal of Biomedical Materials Research}, publisher={Wiley}, author={Okino, H. and Nakayama, Y. and Tanaka, M. and Matsuda, T.}, year={2001}, month=nov, pages={233–245} }

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