Abstract
AbstractClinical multiphoton tomography and two‐photon microendoscopy provide clinicians and researchers with high‐resolution in vivo optical biopsies based on two‐photon autofluorescence, second harmonic generation, and fluorescence lifetime imaging. This review reflects state of the art technology and reports on applications in the fields of early stage melanoma detection, skin aging, nanoparticle imaging, tissue engineering, and in situ screening of pharmaceutical and cosmetical products. So far, more than 500 patients and volunteers in Europe, Asia, and Australia have been investigated with these novel molecular imaging tools. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
References
20
Referenced
244
-
J. B.Pawley(editor) Handbook of biological confocal microscopy Plenum Press New York and London 1995.
(
10.1007/978-1-4757-5348-6
) 10.1364/AO.38.002105
10.1126/science.2321027
10.1016/S0006-3495(97)78886-6
10.1364/OE.3.000339
10.1111/j.1749-6632.1998.tb08187.x
10.1046/j.1365-2818.2000.00738.x
10.1016/j.biomaterials.2004.02.059
10.1117/1.1578644
-
K.König Cellular response to laser radiation in fluorescence microscopes In: Methods in Cellular Imaging (editor: A. Periasamy) Oxford University Press 2001 pp. 236–251.
(
10.1007/978-1-4614-7513-2_14
) {'key': 'e_1_2_1_12_2', 'first-page': '36', 'volume': '6191', 'author': 'Fischer F.', 'year': '2006', 'journal-title': 'SPIE‐Proceed.'}
/ SPIE‐Proceed. by Fischer F. (2006)10.1159/000091974
10.1038/sj.jid.5700374
10.1002/jemt.20445
- B.Messerschmidt A.Kraeplin S.Schenkl I.Riemann M.Stark A.Ehlers A.Tchernook R.LeHarzic andK.König.SPIE‐Proceed. (2007).
10.1002/jemt.20395
10.1364/OL.31.002879
- E.Dimitroff M.Kaatz M.Ziemer J.Köhler J.Norgauer K.König.In press.
10.1227/01.NEU.0000204885.45644.22
10.1159/000080218
Dates
Type | When |
---|---|
Created | 17 years, 7 months ago (Jan. 14, 2008, 7:46 a.m.) |
Deposited | 1 year, 9 months ago (Nov. 14, 2023, 1:30 p.m.) |
Indexed | 2 months, 3 weeks ago (June 7, 2025, 2:23 p.m.) |
Issued | 17 years, 6 months ago (March 1, 2008) |
Published | 17 years, 6 months ago (March 1, 2008) |
Published Online | 17 years, 5 months ago (March 4, 2008) |
Published Print | 17 years, 6 months ago (March 1, 2008) |
@article{K_nig_2008, title={Clinical multiphoton tomography}, volume={1}, ISSN={1864-0648}, url={http://dx.doi.org/10.1002/jbio.200710022}, DOI={10.1002/jbio.200710022}, number={1}, journal={Journal of Biophotonics}, publisher={Wiley}, author={König, Karsten}, year={2008}, month=mar, pages={13–23} }