DOI: 10.1002/iub.99. Proteasome activation as a novel antiaging strategy

Proteasome activation as a novel antiaging strategy

10.1002/iub.99

Crossref journal-article

Wiley

IUBMB Life (311)

Abstract

AbstractHomeostasis is a key feature of cellular lifespan. Maintenance of cellular homeostasis influences the rate of aging and is determined by several factors, including efficient proteolysis of damaged proteins. Protein degradation is predominately catalyzed by the proteasome. Specifically, the proteasome is responsible for cell clearance of abnormal, denatured or in general damaged proteins as well as for the regulated degradation of short‐lived proteins. As proteasome has an impaired function during aging, emphasis has been given recently in identifying ways of its activation. A number of studies have shown that the proteasome can be activated by genetic manipulations as well as by factors that affect its conformation and stability. Importantly the developed proteasome activated cell lines exhibit an extended lifespan. This review article discusses in details the various factors that are involved in proteasome biosynthesis and assembly and how they contribute to its activation. Finally as few natural compounds have been identified having proteasome activation properties, we discuss the advantages of this novel antiaging strategy. © 2008 IUBMB IUBMB Life, 60(10): 651–655, 2008

Bibliography

Chondrogianni, N., & Gonos, E. S. (2008). Proteasome activation as a novel antiaging strategy. IUBMB Life, 60(10), 651â655. Portico.

Authors 2

Niki Chondrogianni (first)
Efstathios S. Gonos (additional)

References 44 Referenced 49

10.1111/j.1749-6632.2000.tb06642.x
10.1038/sj.cdd.4401692
10.1042/BST0350012
10.1016/j.febslet.2007.03.053
10.1515/BC.2007.109
10.1126/science.1141915
10.1007/s00018-004-4130-z
10.1016/j.molcel.2006.11.015
10.1016/j.mad.2005.09.002
10.1016/j.exger.2005.09.004
10.1023/B:BGEN.0000017687.55667.42
10.1016/j.biocel.2004.04.020
10.1074/jbc.M301048200
10.1016/j.biocel.2007.01.002
10.1016/j.febslet.2006.06.029
10.1096/fj.04-2578fje
10.1126/science.287.5462.2486
10.1016/j.abb.2003.10.010
10.1096/fj.06-6751com
10.1073/pnas.91.20.9213
10.1074/jbc.271.29.17275
10.1074/jbc.M413007200
{'key': 'e_1_2_6_24_2', 'first-page': '31', 'article-title': 'Cytoprotective effects of proteasome bet5 subunit overexpression in lens epithelial cells', 'volume': '13', 'author': 'Liu Y.', 'year': '2007', 'journal-title': 'Mol. Vis.'} / Mol. Vis. / Cytoprotective effects of proteasome bet5 subunit overexpression in lens epithelial cells by Liu Y. (2007)
10.1016/j.freeradbiomed.2007.05.029
10.1093/gerona/62.5.490
10.1016/j.exger.2007.01.012
10.1042/bj2280171
10.1016/S1097-2765(01)00274-X
10.1074/jbc.M112360200
10.1021/jf048868m
10.1089/rej.2006.0513
10.1089/ars.2006.8.136
10.1128/MCB.23.23.8786-8794.2003
10.1073/pnas.0712162105
10.1016/S0531-5565(00)00137-6
10.1007/s10522-007-9111-9
10.1196/annals.1395.048
10.1016/j.exger.2004.08.012
10.1074/jbc.M907258199
10.1073/pnas.190268597
10.1128/MCB.25.9.3842-3853.2005
10.1016/S0300-9084(01)01249-4
10.1042/BJ20031122
10.1016/S1357-2725(02)00356-4

Dates

Type	When
Created	17 years, 3 months ago (May 27, 2008, 11:10 p.m.)
Deposited	1 year, 9 months ago (Nov. 14, 2023, 5:17 a.m.)
Indexed	1 month ago (Aug. 6, 2025, 8:06 a.m.)
Issued	17 years, 3 months ago (May 27, 2008)
Published	17 years, 3 months ago (May 27, 2008)
Published Online	17 years, 3 months ago (May 27, 2008)
Published Print	16 years, 11 months ago (Oct. 1, 2008)

Funders 0

None

BibTeX

@article{Chondrogianni_2008, title={Proteasome activation as a novel antiaging strategy}, volume={60}, ISSN={1521-6551}, url={http://dx.doi.org/10.1002/iub.99}, DOI={10.1002/iub.99}, number={10}, journal={IUBMB Life}, publisher={Wiley}, author={Chondrogianni, Niki and Gonos, Efstathios S.}, year={2008}, month=may, pages={651–655} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        6
      ]
    ],
    "date-time": "2025-08-06T12:06:54Z",
    "timestamp": 1754482014730
  },
  "reference-count": 44,
  "publisher": "Wiley",
  "issue": "10",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2008,
            5,
            27
          ]
        ],
        "date-time": "2008-05-27T00:00:00Z",
        "timestamp": 1211846400000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2008,
        10
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title><jats:p>Homeostasis is a key feature of cellular lifespan. Maintenance of cellular homeostasis influences the rate of aging and is determined by several factors, including efficient proteolysis of damaged proteins. Protein degradation is predominately catalyzed by the proteasome. Specifically, the proteasome is responsible for cell clearance of abnormal, denatured or in general damaged proteins as well as for the regulated degradation of short\u2010lived proteins. As proteasome has an impaired function during aging, emphasis has been given recently in identifying ways of its activation. A number of studies have shown that the proteasome can be activated by genetic manipulations as well as by factors that affect its conformation and stability. Importantly the developed proteasome activated cell lines exhibit an extended lifespan. This review article discusses in details the various factors that are involved in proteasome biosynthesis and assembly and how they contribute to its activation. Finally as few natural compounds have been identified having proteasome activation properties, we discuss the advantages of this novel antiaging strategy. \u00a9 2008 IUBMB IUBMB Life, 60(10): 651\u2013655, 2008</jats:p>",
  "DOI": "10.1002/iub.99",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2008,
        5,
        28
      ]
    ],
    "date-time": "2008-05-28T03:10:57Z",
    "timestamp": 1211944257000
  },
  "page": "651-655",
  "source": "Crossref",
  "is-referenced-by-count": 49,
  "title": "Proteasome activation as a novel antiaging strategy",
  "prefix": "10.1002",
  "volume": "60",
  "author": [
    {
      "given": "Niki",
      "family": "Chondrogianni",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Efstathios S.",
      "family": "Gonos",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2008,
        5,
        27
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_6_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1749-6632.2000.tb06642.x"
    },
    {
      "key": "e_1_2_6_3_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/sj.cdd.4401692"
    },
    {
      "key": "e_1_2_6_4_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/BST0350012"
    },
    {
      "key": "e_1_2_6_5_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.febslet.2007.03.053"
    },
    {
      "key": "e_1_2_6_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1515/BC.2007.109"
    },
    {
      "key": "e_1_2_6_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1141915"
    },
    {
      "key": "e_1_2_6_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/s00018-004-4130-z"
    },
    {
      "key": "e_1_2_6_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.molcel.2006.11.015"
    },
    {
      "key": "e_1_2_6_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.mad.2005.09.002"
    },
    {
      "key": "e_1_2_6_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.exger.2005.09.004"
    },
    {
      "key": "e_1_2_6_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1023/B:BGEN.0000017687.55667.42"
    },
    {
      "key": "e_1_2_6_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.biocel.2004.04.020"
    },
    {
      "key": "e_1_2_6_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M301048200"
    },
    {
      "key": "e_1_2_6_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.biocel.2007.01.002"
    },
    {
      "key": "e_1_2_6_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.febslet.2006.06.029"
    },
    {
      "key": "e_1_2_6_17_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1096/fj.04-2578fje"
    },
    {
      "key": "e_1_2_6_18_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.287.5462.2486"
    },
    {
      "key": "e_1_2_6_19_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.abb.2003.10.010"
    },
    {
      "key": "e_1_2_6_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1096/fj.06-6751com"
    },
    {
      "key": "e_1_2_6_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.91.20.9213"
    },
    {
      "key": "e_1_2_6_22_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.29.17275"
    },
    {
      "key": "e_1_2_6_23_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M413007200"
    },
    {
      "key": "e_1_2_6_24_2",
      "first-page": "31",
      "article-title": "Cytoprotective effects of proteasome bet5 subunit overexpression in lens epithelial cells",
      "volume": "13",
      "author": "Liu Y.",
      "year": "2007",
      "journal-title": "Mol. Vis."
    },
    {
      "key": "e_1_2_6_25_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.freeradbiomed.2007.05.029"
    },
    {
      "key": "e_1_2_6_26_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/gerona/62.5.490"
    },
    {
      "key": "e_1_2_6_27_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.exger.2007.01.012"
    },
    {
      "key": "e_1_2_6_28_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/bj2280171"
    },
    {
      "key": "e_1_2_6_29_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(01)00274-X"
    },
    {
      "key": "e_1_2_6_30_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M112360200"
    },
    {
      "key": "e_1_2_6_31_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jf048868m"
    },
    {
      "key": "e_1_2_6_32_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1089/rej.2006.0513"
    },
    {
      "key": "e_1_2_6_33_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1089/ars.2006.8.136"
    },
    {
      "key": "e_1_2_6_34_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.23.23.8786-8794.2003"
    },
    {
      "key": "e_1_2_6_35_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.0712162105"
    },
    {
      "key": "e_1_2_6_36_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0531-5565(00)00137-6"
    },
    {
      "key": "e_1_2_6_37_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/s10522-007-9111-9"
    },
    {
      "key": "e_1_2_6_38_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1196/annals.1395.048"
    },
    {
      "key": "e_1_2_6_39_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.exger.2004.08.012"
    },
    {
      "key": "e_1_2_6_40_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M907258199"
    },
    {
      "key": "e_1_2_6_41_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.190268597"
    },
    {
      "key": "e_1_2_6_42_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.25.9.3842-3853.2005"
    },
    {
      "key": "e_1_2_6_43_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0300-9084(01)01249-4"
    },
    {
      "key": "e_1_2_6_44_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/BJ20031122"
    },
    {
      "key": "e_1_2_6_45_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1357-2725(02)00356-4"
    }
  ],
  "container-title": "IUBMB Life",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fiub.99",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1002/iub.99",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        11,
        14
      ]
    ],
    "date-time": "2023-11-14T10:17:42Z",
    "timestamp": 1699957062000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.99"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2008,
        5,
        27
      ]
    ]
  },
  "references-count": 44,
  "journal-issue": {
    "issue": "10",
    "published-print": {
      "date-parts": [
        [
          2008,
          10
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1002/iub.99"
  ],
  "URL": "http://dx.doi.org/10.1002/iub.99",
  "relation": {},
  "ISSN": [
    "1521-6543",
    "1521-6551"
  ],
  "subject": [],
  "container-title-short": "IUBMB Life",
  "published": {
    "date-parts": [
      [
        2008,
        5,
        27
      ]
    ]
  }
}