DOI: 10.1002/ijc.2910590421. Expression of stromelysin‐1 and timp‐1 in the involuting mammary gland and in early invasive tumors of the mouse

Expression of stromelysin‐1 and timp‐1 in the involuting mammary gland and in early invasive tumors of the mouse

10.1002/ijc.2910590421

Crossref journal-article

Wiley

International Journal of Cancer (311)

Abstract

AbstractThe mammary gland, during post‐lactational involution, is subjected to extensive tissue reconstruction. This process is governed by the concerted expression of extracellular‐matrixdegrading enzymes and their inhibitors. During carcinogenesis, the invasive growth of tumor cells is characterized by the penetration of the basement membrane and stromal invasion. We compared the expression of the tissue‐remodeling enzymes stromelysin‐l, a matrix metalloproteinase, and its inhibitor, tissue inhibitor of metalloproteinase‐l (TIMP‐l), during mammary gland involution and carcinogenesis in mouse. In involuting mammary glands, stromelysin‐l was expressed in myoepithelial cells, whereas TIMP‐l was confined to the stromal tissue. To analyze the involvement of these tissue‐remodeling genes in tumor development, we examined mammary tumors of transgenic mice expressing either the activated Ha‐ras or c‐myc oncogene under the control of a milk‐protein gene promoter. In the undifferentiated and metastasizing Ha‐ras‐induced tumors, stromelysin‐l expression was comparable to that seen in involution, whereas TIMP‐l expression was greatly elevated. During Ha‐ras‐induced carcinogenesis, stromelysin‐l expression was first detected in the myo‐epithelial cells surrounding preneoplastic lesions. In contrast, in the well‐differentiated and non‐metastatic mammary tumors induced by c‐myc, no expression of either gene was observed. Thus, expression of stromelysin‐l and TIMP‐l is confined to the aggressively growing tumors and is induced in the earliest stages of carcinogenesis. © 1994 Wiley‐Liss, Inc.

Bibliography

Li, F., Friis, R. R., Djonov, V., Altermatt, H., Saurer, S., Niemann, H., & Andres, A. (1994). Expression of stromelysinâ1 and timpâ1 in the involuting mammary gland and in early invasive tumors of the mouse. International Journal of Cancer, 59(4), 560â568. Portico.

Authors 7

Feng Li (first)
Robert R. Friis (additional)
Valentin Djonov (additional)
Hans‐Jörg Altermatt (additional)
Susanne Saurer (additional)
Heiner Niemann (additional)
Anne‐Catherine Andres (additional)

References 30 Referenced 44

10.1016/0955-0674(89)90068-9
{'key': 'e_1_2_1_3_1', 'first-page': '771', 'article-title': 'Ha‐ras‐induced transformation of mammary epithelium is favored by increased oncogene expression or by inhibition of mammary regression', 'volume': '6', 'author': 'Andres A.‐C.', 'year': '1991', 'journal-title': 'Oncogene'} / Oncogene / Ha‐ras‐induced transformation of mammary epithelium is favored by increased oncogene expression or by inhibition of mammary regression by Andres A.‐C. (1991)
10.1038/348699a0
10.1042/bj2560413
10.1016/0014-4827(87)90274-6
10.1016/0012-1606(84)90162-3
10.1177/40.5.1315355
{'key': 'e_1_2_1_9_1', 'first-page': '3709', 'article-title': 'Characterization and properties of two monoclonal antibodies specific for the Mr 52,000 precursor of Cathepsin D in human breast‐cancer cells', 'volume': '48', 'author': 'Freiss G.', 'year': '1988', 'journal-title': 'Cancer Res.'} / Cancer Res. / Characterization and properties of two monoclonal antibodies specific for the Mr 52,000 precursor of Cathepsin D in human breast‐cancer cells by Freiss G. (1988)
10.1002/j.1460-2075.1987.tb04804.x
10.1016/0012-1606(88)90288-6
{'key': 'e_1_2_1_12_1', 'first-page': '3154', 'article-title': 'Tumor‐cellderived collagenase‐stimulatory factor increases expression of interstitial collagenase, stromelysin and 72‐kDa gelatinase', 'volume': '53', 'author': 'Kataoka H.', 'year': '1993', 'journal-title': 'Cancer Res.'} / Cancer Res. / Tumor‐cellderived collagenase‐stimulatory factor increases expression of interstitial collagenase, stromelysin and 72‐kDa gelatinase by Kataoka H. (1993)
{'key': 'e_1_2_1_13_1', 'first-page': '335', 'article-title': 'Autocrine and paracrine regulation of tissue inhibitor of metalloproteinases, transin, and urokinase gene expression in metastatic and non‐metastatic mammary carcinoma cells', 'volume': '2', 'author': 'Korczak B.', 'year': '1991', 'journal-title': 'Cell Growth Diff.'} / Cell Growth Diff. / Autocrine and paracrine regulation of tissue inhibitor of metalloproteinases, transin, and urokinase gene expression in metastatic and non‐metastatic mammary carcinoma cells by Korczak B. (1991)
10.1111/j.1475-4754.1982.tb01001.x
10.1016/0168-9525(90)90126-Q
10.1128/MCB.6.5.1679
10.1021/bi00438a042
10.1016/0092-8674(79)90108-9
10.1083/jcb.108.3.1127
10.1242/dev.113.3.867 / Development / Regulated expression and growth‐inhibitory effects of transforming‐growth‐factor‐β isoforms in mouse mammarygland development by Robinson S. D. (1991)
10.1016/S0002-9378(12)90922-9
10.1002/j.1460-2075.1988.tb02797.x / EMBO. J. / Targeted c‐myc expression in mammary glands of transgenic mice induces mammary tumors with constitutive milk‐protein transcription by Schönenberger C.‐A. (1988)
10.1016/S0021-9258(18)77438-3 / J. biol. Chem. / Tissue inhibitor of metalloproteinases‐2 (TIMP‐2) mRNA expression in tumor cell lines and human tumor tissues by Stetler W. G. (1990)
10.1242/dev.115.1.49 / Development / Apoptotic cell death and tissue remodelling during mouse mammary‐gland involution by Strange R. (1992)
10.1083/jcb.110.4.1405
10.1083/jcb.120.1.253
10.1002/ijc.2910500303
10.1083/jcb.118.5.1271
10.1073/pnas.77.9.5201
10.1002/aja.1001850104
10.1073/pnas.84.19.6725

Dates

Type	When
Created	18 years, 6 months ago (Feb. 19, 2007, 7:16 p.m.)
Deposited	1 year, 10 months ago (Oct. 24, 2023, 9:08 a.m.)
Indexed	2 months ago (July 1, 2025, 9:49 a.m.)
Issued	30 years, 9 months ago (Nov. 15, 1994)
Published	30 years, 9 months ago (Nov. 15, 1994)
Published Online	19 years, 1 month ago (July 17, 2006)
Published Print	30 years, 9 months ago (Nov. 15, 1994)

Funders 0

None

BibTeX

@article{Li_1994, title={Expression of stromelysin‐1 and timp‐1 in the involuting mammary gland and in early invasive tumors of the mouse}, volume={59}, ISSN={1097-0215}, url={http://dx.doi.org/10.1002/ijc.2910590421}, DOI={10.1002/ijc.2910590421}, number={4}, journal={International Journal of Cancer}, publisher={Wiley}, author={Li, Feng and Friis, Robert R. and Djonov, Valentin and Altermatt, Hans‐Jörg and Saurer, Susanne and Niemann, Heiner and Andres, Anne‐Catherine}, year={1994}, month=nov, pages={560–568} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        1
      ]
    ],
    "date-time": "2025-07-01T13:49:09Z",
    "timestamp": 1751377749243
  },
  "reference-count": 30,
  "publisher": "Wiley",
  "issue": "4",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2006,
            7,
            17
          ]
        ],
        "date-time": "2006-07-17T00:00:00Z",
        "timestamp": 1153094400000
      },
      "content-version": "vor",
      "delay-in-days": 4262,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1994,
        11,
        15
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title><jats:p>The mammary gland, during post\u2010lactational involution, is subjected to extensive tissue reconstruction. This process is governed by the concerted expression of extracellular\u2010matrixdegrading enzymes and their inhibitors. During carcinogenesis, the invasive growth of tumor cells is characterized by the penetration of the basement membrane and stromal invasion. We compared the expression of the tissue\u2010remodeling enzymes stromelysin\u2010l, a matrix metalloproteinase, and its inhibitor, tissue inhibitor of metalloproteinase\u2010l (TIMP\u2010l), during mammary gland involution and carcinogenesis in mouse. In involuting mammary glands, stromelysin\u2010l was expressed in myoepithelial cells, whereas TIMP\u2010l was confined to the stromal tissue. To analyze the involvement of these tissue\u2010remodeling genes in tumor development, we examined mammary tumors of transgenic mice expressing either the activated Ha\u2010<jats:italic>ras</jats:italic> or c\u2010<jats:italic>myc</jats:italic> oncogene under the control of a milk\u2010protein gene promoter. In the undifferentiated and metastasizing Ha\u2010<jats:italic>ras</jats:italic>\u2010induced tumors, stromelysin\u2010l expression was comparable to that seen in involution, whereas TIMP\u2010l expression was greatly elevated. During Ha\u2010<jats:italic>ras</jats:italic>\u2010induced carcinogenesis, stromelysin\u2010l expression was first detected in the myo\u2010epithelial cells surrounding preneoplastic lesions. In contrast, in the well\u2010differentiated and non\u2010metastatic mammary tumors induced by c\u2010<jats:italic>myc</jats:italic>, no expression of either gene was observed. Thus, expression of stromelysin\u2010l and TIMP\u2010l is confined to the aggressively growing tumors and is induced in the earliest stages of carcinogenesis. \u00a9 1994 Wiley\u2010Liss, Inc.</jats:p>",
  "DOI": "10.1002/ijc.2910590421",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2007,
        2,
        20
      ]
    ],
    "date-time": "2007-02-20T00:16:31Z",
    "timestamp": 1171930591000
  },
  "page": "560-568",
  "source": "Crossref",
  "is-referenced-by-count": 44,
  "title": "Expression of stromelysin\u20101 and timp\u20101 in the involuting mammary gland and in early invasive tumors of the mouse",
  "prefix": "10.1002",
  "volume": "59",
  "author": [
    {
      "given": "Feng",
      "family": "Li",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Robert R.",
      "family": "Friis",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Valentin",
      "family": "Djonov",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Hans\u2010J\u00f6rg",
      "family": "Altermatt",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Susanne",
      "family": "Saurer",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Heiner",
      "family": "Niemann",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Anne\u2010Catherine",
      "family": "Andres",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2006,
        7,
        17
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_2_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0955-0674(89)90068-9"
    },
    {
      "key": "e_1_2_1_3_1",
      "first-page": "771",
      "article-title": "Ha\u2010ras\u2010induced transformation of mammary epithelium is favored by increased oncogene expression or by inhibition of mammary regression",
      "volume": "6",
      "author": "Andres A.\u2010C.",
      "year": "1991",
      "journal-title": "Oncogene"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/348699a0"
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/bj2560413"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-4827(87)90274-6"
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0012-1606(84)90162-3"
    },
    {
      "key": "e_1_2_1_8_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1177/40.5.1315355"
    },
    {
      "key": "e_1_2_1_9_1",
      "first-page": "3709",
      "article-title": "Characterization and properties of two monoclonal antibodies specific for the Mr 52,000 precursor of Cathepsin D in human breast\u2010cancer cells",
      "volume": "48",
      "author": "Freiss G.",
      "year": "1988",
      "journal-title": "Cancer Res."
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1987.tb04804.x"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0012-1606(88)90288-6"
    },
    {
      "key": "e_1_2_1_12_1",
      "first-page": "3154",
      "article-title": "Tumor\u2010cellderived collagenase\u2010stimulatory factor increases expression of interstitial collagenase, stromelysin and 72\u2010kDa gelatinase",
      "volume": "53",
      "author": "Kataoka H.",
      "year": "1993",
      "journal-title": "Cancer Res."
    },
    {
      "key": "e_1_2_1_13_1",
      "first-page": "335",
      "article-title": "Autocrine and paracrine regulation of tissue inhibitor of metalloproteinases, transin, and urokinase gene expression in metastatic and non\u2010metastatic mammary carcinoma cells",
      "volume": "2",
      "author": "Korczak B.",
      "year": "1991",
      "journal-title": "Cell Growth Diff."
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1475-4754.1982.tb01001.x"
    },
    {
      "key": "e_1_2_1_15_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0168-9525(90)90126-Q"
    },
    {
      "key": "e_1_2_1_16_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.6.5.1679"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00438a042"
    },
    {
      "key": "e_1_2_1_18_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(79)90108-9"
    },
    {
      "key": "e_1_2_1_19_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.108.3.1127"
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "crossref",
      "first-page": "867",
      "DOI": "10.1242/dev.113.3.867",
      "article-title": "Regulated expression and growth\u2010inhibitory effects of transforming\u2010growth\u2010factor\u2010\u03b2 isoforms in mouse mammarygland development",
      "volume": "118",
      "author": "Robinson S. D.",
      "year": "1991",
      "journal-title": "Development"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0002-9378(12)90922-9"
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "crossref",
      "first-page": "169",
      "DOI": "10.1002/j.1460-2075.1988.tb02797.x",
      "article-title": "Targeted c\u2010myc expression in mammary glands of transgenic mice induces mammary tumors with constitutive milk\u2010protein transcription",
      "volume": "7",
      "author": "Sch\u00f6nenberger C.\u2010A.",
      "year": "1988",
      "journal-title": "EMBO. J."
    },
    {
      "key": "e_1_2_1_23_1",
      "doi-asserted-by": "crossref",
      "first-page": "13933",
      "DOI": "10.1016/S0021-9258(18)77438-3",
      "article-title": "Tissue inhibitor of metalloproteinases\u20102 (TIMP\u20102) mRNA expression in tumor cell lines and human tumor tissues",
      "volume": "265",
      "author": "Stetler W. G.",
      "year": "1990",
      "journal-title": "J. biol. Chem."
    },
    {
      "key": "e_1_2_1_24_1",
      "doi-asserted-by": "crossref",
      "first-page": "49",
      "DOI": "10.1242/dev.115.1.49",
      "article-title": "Apoptotic cell death and tissue remodelling during mouse mammary\u2010gland involution",
      "volume": "115",
      "author": "Strange R.",
      "year": "1992",
      "journal-title": "Development"
    },
    {
      "key": "e_1_2_1_25_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.110.4.1405"
    },
    {
      "key": "e_1_2_1_26_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.120.1.253"
    },
    {
      "key": "e_1_2_1_27_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/ijc.2910500303"
    },
    {
      "key": "e_1_2_1_28_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.118.5.1271"
    },
    {
      "key": "e_1_2_1_29_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.77.9.5201"
    },
    {
      "key": "e_1_2_1_30_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/aja.1001850104"
    },
    {
      "key": "e_1_2_1_31_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.84.19.6725"
    }
  ],
  "container-title": "International Journal of Cancer",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.2910590421",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.2910590421",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        24
      ]
    ],
    "date-time": "2023-10-24T13:08:51Z",
    "timestamp": 1698152931000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1002/ijc.2910590421"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1994,
        11,
        15
      ]
    ]
  },
  "references-count": 30,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          1994,
          11,
          15
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1002/ijc.2910590421"
  ],
  "URL": "http://dx.doi.org/10.1002/ijc.2910590421",
  "relation": {},
  "ISSN": [
    "0020-7136",
    "1097-0215"
  ],
  "subject": [],
  "container-title-short": "Intl Journal of Cancer",
  "published": {
    "date-parts": [
      [
        1994,
        11,
        15
      ]
    ]
  }
}