DOI: 10.1002/ijc.2910530111. p53 mutations and aflatoxin B<sub>1</sub> exposure in hepatocellular carcinoma patients from thailand

p53 mutations and aflatoxin B1 exposure in hepatocellular carcinoma patients from thailand

10.1002/ijc.2910530111

Crossref journal-article

Wiley

International Journal of Cancer (311)

Abstract

AbstractThe prevalence and type of mutations in the p53 tumoursuppressor gene have been determined in 15 hepatocellular carcinomas (HCC) originating from Thailand. Direct sequencing of exons 5‐8 revealed 2 mutations, an AGG to AGT (Arg → Ser) transversion at codon 249, and an ATC → AAC (lle → Asn) transversion at codon 254. Samples from the Thai patients were analyzed for the presence of aflatoxin‐liver DNA and aflatoxinserum albumin adducts, and all but one were found negative. All the patients were genotyped for glutathione‐S‐transferase (GST) μ, an enzyme possibly involved in the detoxification of AFB1, and 12 out of 15 had the null genotype. In general, the level of aflatoxin‐albumin adducts in sera and the prevalence of p53 mutation at codon 249 in HCC were lower than in other areas at high risk of HCC, including southern China and parts of Africa.

Bibliography

Hollstein, M. C., Wild, C. P., Bleicher, F., Chutimataewin, S., Harris, C. C., Srivatanakul, A., & Montesano, R. (1993). p53 mutations and aflatoxin B1 exposure in hepatocellular carcinoma patients from thailand. International Journal of Cancer, 53(1), 51â55. Portico.

Authors 7

Monica C. Hollstein (first)
Christopher P. Wild (additional)
Françoise Bleicher (additional)
Sopa Chutimataewin (additional)
Curtis C. Harris (additional)
Andpetcharin Srivatanakul (additional)
Ruggero Montesano (additional)

References 30 Referenced 62

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Dates

Type	When
Created	18 years, 6 months ago (Feb. 19, 2007, 6:27 p.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 9:08 p.m.)
Indexed	1 year, 6 months ago (Feb. 21, 2024, 7:23 a.m.)
Issued	32 years, 8 months ago (Jan. 2, 1993)
Published	32 years, 8 months ago (Jan. 2, 1993)
Published Online	19 years, 1 month ago (July 17, 2006)
Published Print	32 years, 8 months ago (Jan. 2, 1993)

Funders 0

None

BibTeX

@article{Hollstein_1993, title={p53 mutations and aflatoxin B1 exposure in hepatocellular carcinoma patients from thailand}, volume={53}, ISSN={1097-0215}, url={http://dx.doi.org/10.1002/ijc.2910530111}, DOI={10.1002/ijc.2910530111}, number={1}, journal={International Journal of Cancer}, publisher={Wiley}, author={Hollstein, Monica C. and Wild, Christopher P. and Bleicher, Françoise and Chutimataewin, Sopa and Harris, Curtis C. and Srivatanakul, Andpetcharin and Montesano, Ruggero}, year={1993}, month=jan, pages={51–55} }

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