DOI: 10.1002/ijc.2910510418. Unusual expression and localization of heat‐shock proteins in human tumor cells

Unusual expression and localization of heat‐shock proteins in human tumor cells

10.1002/ijc.2910510418

Crossref journal-article

Wiley

International Journal of Cancer (311)

Abstract

AbstractIt has been suggested that members of HSP families represent the surface target of immune responses leading to tumor rejection in mice. Here we report that tumor cells, compared with normal cells, constitutively expressed 2‐ to 10‐fold higher levels of intracellular HSP90. Moreover, in the absence of environmental stress, 2 lines (out of 6) expressed the “inducible” HSP72, which was also detectable in fresh tumor cells. HSP72 expression was not regulated during the cell cycle, in contrast with what has been observed with normal cells. Both HSP90 and HSP72 proteins exhibited a heterogeneous pattern of intracellular distribution in most cells, HSP72 being confined mainly to the nuclear compartment. Finally, we could detect both HSP90 and, to a lesser extent, HSP72 (that are generally believed to be located intracellularly) at the surface of some tumor cell lines. We conclude that tumor cells differ from normal cells in their pattern of HSP expression; this might imply a role of HSPs in eliciting an immune response against cancer.

Bibliography

Ferrarini, M., Heltai, S., Zocchi, M. R., & Rugarli, C. (1992). Unusual expression and localization of heatâshock proteins in human tumor cells. International Journal of Cancer, 51(4), 613â619. Portico.

Authors 4

Marina Ferrarini (first)
Silvia Heltai (additional)
M. Raffaella Zocchi (additional)
Claudio Rugarli (additional)

References 29 Referenced 344

10.1126/science.2188360
10.1016/0092-8674(89)90019-6
10.1016/0167-5699(90)90015-2 / Immunol. Today / Recognition of heat‐shock proteins and gamma delta cell function by Born W. (1990)
10.1016/0923-2494(89)90019-9
10.1038/bjc.1990.372
10.1073/pnas.85.11.3850
10.1128/MCB.8.2.531
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10.1007/978-1-4613-2825-4_1
10.1016/0167-5699(90)90050-J
10.1007/978-3-642-75875-1_11
{'key': 'e_1_2_1_15_1', 'first-page': '6578', 'article-title': 'Heat‐ or stress‐inducible transformation‐associated cell‐surface antigen on the activated H‐ras‐oncogene‐transfected rat fibroblast', 'volume': '49', 'author': 'Konno A.', 'year': '1989', 'journal-title': 'Cancer Res.'} / Cancer Res. / Heat‐ or stress‐inducible transformation‐associated cell‐surface antigen on the activated H‐ras‐oncogene‐transfected rat fibroblast by Konno A. (1989)
10.1038/227680a0
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10.1002/anr.1780321202
10.1002/eji.1830201224

Dates

Type	When
Created	18 years, 6 months ago (Feb. 19, 2007, 5:56 p.m.)
Deposited	1 year, 10 months ago (Oct. 24, 2023, 1:48 a.m.)
Indexed	1 month ago (Aug. 6, 2025, 8:24 a.m.)
Issued	33 years, 2 months ago (June 19, 1992)
Published	33 years, 2 months ago (June 19, 1992)
Published Online	19 years, 1 month ago (July 17, 2006)
Published Print	33 years, 2 months ago (June 19, 1992)

Funders 0

None

BibTeX

@article{Ferrarini_1992, title={Unusual expression and localization of heat‐shock proteins in human tumor cells}, volume={51}, ISSN={1097-0215}, url={http://dx.doi.org/10.1002/ijc.2910510418}, DOI={10.1002/ijc.2910510418}, number={4}, journal={International Journal of Cancer}, publisher={Wiley}, author={Ferrarini, Marina and Heltai, Silvia and Zocchi, M. Raffaella and Rugarli, Claudio}, year={1992}, month=jun, pages={613–619} }

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