DOI: 10.1002/ijc.2910430614. High frequency of Ki‐<i>ras</i> codon 12 mutations in pancreatic adenocarcinomas

High frequency of Ki‐ras codon 12 mutations in pancreatic adenocarcinomas

10.1002/ijc.2910430614

Crossref journal-article

Wiley

International Journal of Cancer (311)

Abstract

AbstractThe frequency of Ki‐ras gene mutations was studied in 100 paraffin‐embedded sections obtained from 63 pancreatic adenocarcinomas by in vitro amplification of target sequences via polymerase chain reaction (PCR) and selective oligonucleotide hybridization. Forty‐seven (75%) of the tumors contained a Ki‐ras mutation at codon 12. No predominant amino acid substitution or nucleotide transition at this codon was observed. Two carcinomas exhibited 2 distinct Ki‐ras mutations. No particular correlation could be established between the incidence of Ki‐ras mutation and clinical parameters (sex, age, survival), tumor grade or tumor stage.

Bibliography

GrÃ¼newald, K., Lyons, J., FrÃ¶hlich, A., Feichtinger, H., Weger, R. A., Schwab, G., Janssen, J. W. G., & Bartram, C. R. (1989). High frequency of Kiâras codon 12 mutations in pancreatic adenocarcinomas. International Journal of Cancer, 43(6), 1037â1041. Portico.

Authors 8

Kurt Grünewald (first)
John Lyons (additional)
Anja Fröhlich (additional)
Hans Feichtinger (additional)
Richard A. Weger (additional)
Gerhard Schwab (additional)
Johannes W. G. Janssen (additional)
Claus R. Bartram (additional)

References 18 Referenced 223

10.1016/0092-8674(88)90571-5
American Joint Committee for Cancer Staging and End‐Results Reporting.In: American Joint Committee on Cancer (ed.) Manual for staging of cancer pp.85–88 Chicago (1977).
10.1146/annurev.bi.56.070187.004023
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{'key': 'e_1_2_1_9_1', 'first-page': '186', 'article-title': 'Detection of high incidence of K‐ras oncogenes during human carcinogenesis', 'volume': '330', 'author': 'Forrester K.', 'year': '1987', 'journal-title': 'Nature (lond.)'} / Nature (lond.) / Detection of high incidence of K‐ras oncogenes during human carcinogenesis by Forrester K. (1987)
10.1093/nar/15.14.5669
{'key': 'e_1_2_1_11_1', 'first-page': '79', 'volume-title': 'Pancreatic pathology', 'author': 'Kloeppel G.', 'year': '1984'} / Pancreatic pathology by Kloeppel G. (1984)
10.1182/blood.V71.6.1707.1707 / Blood / Mutations of Ki‐ras and N‐ras oncogenes in myelodysplastic syndromes by Lyons J. (1988)
{'key': 'e_1_2_1_13_1', 'first-page': '163', 'article-title': 'Evaluation of survival data and two new rank order statistics arising in its consideration', 'volume': '50', 'author': 'Mantel E.', 'year': '1966', 'journal-title': 'Cancer Chemother. Rep.'} / Cancer Chemother. Rep. / Evaluation of survival data and two new rank order statistics arising in its consideration by Mantel E. (1966)
{'key': 'e_1_2_1_14_1', 'first-page': '503', 'article-title': 'Ras mutations in myelodysplasia detected by amplification, oligonucleotide hybridization, and transformation', 'volume': '2', 'author': 'Padua R. A.', 'year': '1988', 'journal-title': 'Leukemia'} / Leukemia / Ras mutations in myelodysplasia detected by amplification, oligonucleotide hybridization, and transformation by Padua R. A. (1988)
10.1016/0092-8674(87)90710-0
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{'key': 'e_1_2_1_19_1', 'first-page': '2228', 'article-title': 'An epidemiologic evaluation of the causes of cancer of the pancreas', 'volume': '35', 'author': 'Wynder E. L.', 'year': '1975', 'journal-title': 'Cancer Res.'} / Cancer Res. / An epidemiologic evaluation of the causes of cancer of the pancreas by Wynder E. L. (1975)

Dates

Type	When
Created	18 years, 6 months ago (Feb. 19, 2007, 4:45 p.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 7:13 a.m.)
Indexed	1 month, 1 week ago (July 30, 2025, 10:03 a.m.)
Issued	36 years, 2 months ago (June 15, 1989)
Published	36 years, 2 months ago (June 15, 1989)
Published Online	19 years, 1 month ago (July 17, 2006)
Published Print	36 years, 2 months ago (June 15, 1989)

Funders 0

None

BibTeX

@article{Gr_newald_1989, title={High frequency of Ki‐ras codon 12 mutations in pancreatic adenocarcinomas}, volume={43}, ISSN={1097-0215}, url={http://dx.doi.org/10.1002/ijc.2910430614}, DOI={10.1002/ijc.2910430614}, number={6}, journal={International Journal of Cancer}, publisher={Wiley}, author={Grünewald, Kurt and Lyons, John and Fröhlich, Anja and Feichtinger, Hans and Weger, Richard A. and Schwab, Gerhard and Janssen, Johannes W. G. and Bartram, Claus R.}, year={1989}, month=jun, pages={1037–1041} }

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