DOI: 10.1002/ijc.2910410512. Smooth‐muscle differentiation in stromal cells of malignant and non‐malignant breast tissues

Smooth‐muscle differentiation in stromal cells of malignant and non‐malignant breast tissues

10.1002/ijc.2910410512

Crossref journal-article

Wiley

International Journal of Cancer (311)

Abstract

AbstractA mouse monoclonal antibody (MAb) recognizing α‐smooth‐muscle actin has been used to study smooth‐muscle differentiation features in the stromal cells of desmoplastic reactions accompanying mammary tumors. We have studied, by the same immunohistochemical technique, a series of malignant and non‐malignant human breast tissues. Cells composing the desmoplastic reaction were found to express α‐smooth‐muscle actin in all the 11 breast carcinomas examined, whereas no immunostain was demonstrated in the stromal cells of 7 breast tissue samples histologically defined as normal. Three of 9 cases of fibrocystic disease showed a minority of positively stained stromal cells, generally in association with epithelial hyperplasia. All the 7 cases of sclerosing adenosis, 3 of 4 cases of diffuse papillomatosis and all 3 intraductal papillomas exhibited a majority of immunoreactive stromal cells. Numerous stromal cells in 3 of 11 circumscribed fibroadenomas analyzed expressed low amounts of α‐smooth‐muscle actin. The factor(s) responsible for smooth‐muscle differentiation in stromal cells are presently unknown, but the detection of this previously unsuspected stromal cell phenotype in non‐malignant mammary tissues might help in characterizing the variant morphological aspects designated under the label “fibrocystic disease” and in understanding the biology of pre‐malignant or early malignant lesions of the breast.

Bibliography

Sappino, A. âP., Skalli, O., Jackson, B., SchÃ¼rch, W., & Gabbiani, G. (1988). Smoothâmuscle differentiation in stromal cells of malignant and nonâmalignant breast tissues. International Journal of Cancer, 41(5), 707â712. Portico.

Authors 5

A.‐P. Sappino (first)
O. Skalli (additional)
B. Jackson (additional)
W. Schürch (additional)
G. Gabbiani (additional)

References 40 Referenced 248

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Dates

Type	When
Created	18 years, 6 months ago (Feb. 19, 2007, 4:20 p.m.)
Deposited	1 year, 11 months ago (Sept. 26, 2023, 8:44 p.m.)
Indexed	4 days, 12 hours ago (Sept. 3, 2025, 7:06 a.m.)
Issued	37 years, 3 months ago (May 15, 1988)
Published	37 years, 3 months ago (May 15, 1988)
Published Online	19 years, 1 month ago (July 18, 2006)
Published Print	37 years, 3 months ago (May 15, 1988)

Funders 0

None

BibTeX

@article{Sappino_1988, title={Smooth‐muscle differentiation in stromal cells of malignant and non‐malignant breast tissues}, volume={41}, ISSN={1097-0215}, url={http://dx.doi.org/10.1002/ijc.2910410512}, DOI={10.1002/ijc.2910410512}, number={5}, journal={International Journal of Cancer}, publisher={Wiley}, author={Sappino, A.‐P. and Skalli, O. and Jackson, B. and Schürch, W. and Gabbiani, G.}, year={1988}, month=may, pages={707–712} }

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