DOI: 10.1002/ijc.2910260416. Transformed and neoplastic phenotype: Reversibility during culture by cell density and cell shape

Transformed and neoplastic phenotype: Reversibility during culture by cell density and cell shape

10.1002/ijc.2910260416

Crossref journal-article

Wiley

International Journal of Cancer (311)

Abstract

AbstractThe ability of parental and transformed mouse C3H (10T1/2) cells to grow when held at a graded series of cell shapes (flat to round) was studied using substrata of decreasing adhesivity. The parental cells showed a decrease in growth when they reached the most rounded configurations. In contrast, transformed cells proliferated at the same rate regardless of cell shape. In addition, when transformed cells were serially passaged at low density on highly adhesive plastic, which maintained cells in a flat configuration, a reversion from the transformed phenotype to a non‐transformed phenotype occurred with the concomitant return of growth control by cell shape. However, when transformed cells were passaged at low density on a substratum which prevented cell spreading, the reversion to the parental phenotype did not occur and the cells escaped the growth control of cell shape and remained tumorigenic. Thus, in this cell system it appears that a change in cell configuration can dictate whether or not the transformed and neoplastic phenotype will be expressed.

Bibliography

Broutyâboye, D., Tucker, R. W., & Folkman, T. (1980). Transformed and neoplastic phenotype: Reversibility during culture by cell density and cell shape. International Journal of Cancer, 26(4), 501â507. Portico.

Authors 3

Danièle Brouty‐boye (first)
Robert W. Tucker (additional)
Tudah Folkman (additional)

References 11 Referenced 24

10.1016/0092-8674(78)90347-1
10.1002/ijc.2910240218
10.1002/ijc.2910240219
10.1073/pnas.74.10.4466
10.1038/273345a0
10.1016/B978-0-12-612984-7.50022-0 / The cell surfaces: Mediator of developmental processes by Folkman J. (1980)
{'key': 'e_1_2_1_8_1', 'first-page': '4155', 'article-title': 'Determination of cellular shape by the extracellular matrix and its correlation with the control of cellular growth', 'volume': '38', 'author': 'Gospodarowicz D.', 'year': '1978', 'journal-title': 'Cancer Res.'} / Cancer Res. / Determination of cellular shape by the extracellular matrix and its correlation with the control of cellular growth by Gospodarowicz D. (1978)
10.1016/0012-1606(76)90014-2
{'key': 'e_1_2_1_10_1', 'first-page': '2331', 'article-title': 'Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to post‐confluence inhibition of cell division', 'volume': '33', 'author': 'Reznikoff C. A.', 'year': '1973', 'journal-title': 'Cancer Res.'} / Cancer Res. / Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to post‐confluence inhibition of cell division by Reznikoff C. A. (1973)
Tucker R. W. andFolkman J. Interaction of serum and cell spreading on the growth of neoplastic and nonneoplastic fibroblasts. J. Supramol. Struct (in press) (1980).
10.1016/0092-8674(77)90024-1

Dates

Type	When
Created	18 years, 6 months ago (Feb. 19, 2007, 1:01 p.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 9:08 a.m.)
Indexed	1 year, 7 months ago (Jan. 14, 2024, 5:42 p.m.)
Issued	44 years, 10 months ago (Oct. 15, 1980)
Published	44 years, 10 months ago (Oct. 15, 1980)
Published Online	19 years, 1 month ago (July 17, 2006)
Published Print	44 years, 10 months ago (Oct. 15, 1980)

Funders 0

None

BibTeX

@article{Brouty_boye_1980, title={Transformed and neoplastic phenotype: Reversibility during culture by cell density and cell shape}, volume={26}, ISSN={1097-0215}, url={http://dx.doi.org/10.1002/ijc.2910260416}, DOI={10.1002/ijc.2910260416}, number={4}, journal={International Journal of Cancer}, publisher={Wiley}, author={Brouty‐boye, Danièle and Tucker, Robert W. and Folkman, Tudah}, year={1980}, month=oct, pages={501–507} }

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