DOI: 10.1002/ijc.2910210611. Initial tumor cell arrest in animals of defined coagulative status

Initial tumor cell arrest in animals of defined coagulative status

10.1002/ijc.2910210611

Crossref journal-article

Wiley

International Journal of Cancer (311)

Abstract

AbstractExperiments were made to evaluate the potential role played by thrombogenic factors on the hematogenous arrest of circulating tumor cells in mice with demonstrable coagulopathies associated with the presence of a primary tumor, by administration of “therapeutic” doses of anticoagulants. The effects of warfarin, aspirin and heparin administration on the early arrest patterns of 125IdUrd‐labelled TA3 carcinoma and Gardner lympho‐sarcoma cells injected intravenously into tumor‐bearing mice were examined. Several hematologic parameters of carcinoma‐ and lymphosarcoma‐bearing animals were measured prior to anti‐coagulation experiments and the results indicated that mice had coagulopathies similar to those found in cancer patients with disseminated intra‐vascular coagulation syndrome, i.e., thrombocyto‐penia and elevated fibrinogen levels. Despite the presence of coagulation abnormalities and effective anticoagulation in recipient animals, all three agents were without effect on localization patterns of both tumor types. It was concluded that the proposed involvement of thrombogenesis in metastasis was probably not due to any role played by those clotting factors inhibited by aspirin, warfarin and heparin in early intravascular tumor cell arrest.

Bibliography

Glaves, D., & Weiss, L. (1978). Initial tumor cell arrest in animals of defined coagulative status. International Journal of Cancer, 21(6), 741â746. Portico.

Authors 2

D. Glaves (first)
L. Weiss (additional)

References 28 Referenced 13

{'key': 'e_1_2_1_2_1', 'first-page': '141', 'article-title': 'Fibrinogen levels and pulmonary metastases in rats', 'volume': '87', 'author': 'Agostino D.', 'year': '1969', 'journal-title': 'Arch. Path.'} / Arch. Path. / Fibrinogen levels and pulmonary metastases in rats by Agostino D. (1969)
{'key': 'e_1_2_1_3_1', 'first-page': '433', 'article-title': 'Hematologic changes and thromboembolic complications in neoplastic disease and their relationship to metastasis', 'volume': '6', 'author': 'Ambrus J. L.', 'year': '1976', 'journal-title': 'J. Med.'} / J. Med. / Hematologic changes and thromboembolic complications in neoplastic disease and their relationship to metastasis by Ambrus J. L. (1976)
{'key': 'e_1_2_1_4_1', 'first-page': '1217', 'article-title': 'A study of the mechanism by which anti‐coagulation with warfarin inhibits blood‐borne metastases', 'volume': '33', 'author': 'Brown J. M.', 'year': '1973', 'journal-title': 'Cancer Res.'} / Cancer Res. / A study of the mechanism by which anti‐coagulation with warfarin inhibits blood‐borne metastases by Brown J. M. (1973)
{'key': 'e_1_2_1_5_1', 'article-title': 'Demonstration of fibrin in early stages of experimental metastases', 'volume': '36', 'author': 'Chew E‐C.', 'year': '1904', 'journal-title': 'Cancer Res.'} / Cancer Res. / Demonstration of fibrin in early stages of experimental metastases by Chew E‐C. (1904)
10.1002/1097-0142(1955)8:6<1146::AID-CNCR2820080610>3.0.CO;2-W
{'key': 'e_1_2_1_7_1', 'first-page': '421', 'article-title': 'Anticoagulants and tumor cell lodgement', 'volume': '27', 'author': 'Fisher B.', 'year': '1967', 'journal-title': 'Cancer Res.'} / Cancer Res. / Anticoagulants and tumor cell lodgement by Fisher B. (1967)
10.1002/ijc.2910110322
10.1111/j.1749-6632.1974.tb14459.x
{'key': 'e_1_2_1_10_1', 'first-page': '1', 'article-title': 'Experimental tumor metastases and blood coagulability', 'volume': '211', 'author': 'Hagmar B.', 'year': '1970', 'journal-title': 'Acta path. microbiol. Scand.'} / Acta path. microbiol. Scand. / Experimental tumor metastases and blood coagulability by Hagmar B. (1970)
10.1016/0014-2964(72)90079-5
10.1016/0145-2126(77)90022-4
10.1038/bjc.1973.168
10.1016/0014-2964(72)90031-X
10.1111/j.1365-2141.1973.tb05745.x
10.1002/ijc.2910090203
{'key': 'e_1_2_1_17_1', 'first-page': '625', 'article-title': 'The optimal level of anticoagulation for decreasing experimental metastases', 'volume': '79', 'author': 'Hoover H. C.', 'year': '1976', 'journal-title': 'Surgery'} / Surgery / The optimal level of anticoagulation for decreasing experimental metastases by Hoover H. C. (1976)
10.1038/bjc.1975.252
{'key': 'e_1_2_1_19_1', 'first-page': '289', 'article-title': 'Quantitative study on thromboplastin in various strains of Yoshida ascites hepatoma cells of rat', 'volume': '65', 'author': 'Khato J.', 'year': '1974', 'journal-title': 'Gann'} / Gann / Quantitative study on thromboplastin in various strains of Yoshida ascites hepatoma cells of rat by Khato J. (1974)
10.1111/j.1749-6632.1974.tb14460.x
10.1007/BF02950524
{'key': 'e_1_2_1_22_1', 'first-page': '219', 'article-title': 'Fibrinolysis in human malignant tumours', 'volume': '139', 'author': 'Peterson H. I.', 'year': '1973', 'journal-title': 'Acta. Chir. Scand.'} / Acta. Chir. Scand. / Fibrinolysis in human malignant tumours by Peterson H. I. (1973)
{'key': 'e_1_2_1_23_1', 'first-page': '272', 'article-title': 'Blood coagulation changes in mice bearing Lewis lung carcinoma, a metastasizing tumor', 'volume': '37', 'author': 'Poggi A.', 'year': '1977', 'journal-title': 'Cancer Res.'} / Cancer Res. / Blood coagulation changes in mice bearing Lewis lung carcinoma, a metastasizing tumor by Poggi A. (1977)
10.1136/bmj.1.5792.110-e
10.1002/1097-0142(197501)35:1<91::AID-CNCR2820350114>3.0.CO;2-Z
{'key': 'e_1_2_1_26_1', 'first-page': '139', 'article-title': 'Tumor metastasis and thrombosis', 'volume': '59', 'author': 'Warren B. A.', 'year': '1974', 'journal-title': 'Thromb. Diath. Haem. Suppl.'} / Thromb. Diath. Haem. Suppl. / Tumor metastasis and thrombosis by Warren B. A. (1974)
{'key': 'e_1_2_1_27_1', 'first-page': '301', 'article-title': 'The adhesion of thrombo‐plastic tumour emboli to vessel walls in vivo', 'volume': '53', 'author': 'Warren B. A.', 'year': '1972', 'journal-title': 'Brit. J. exp. Path.'} / Brit. J. exp. Path. / The adhesion of thrombo‐plastic tumour emboli to vessel walls in vivo by Warren B. A. (1972)
10.1002/ijc.2910180608
{'key': 'e_1_2_1_29_1', 'first-page': '550', 'article-title': 'Pathogenesis of metastasis formation observed in vivo in the rabbit ear chamber', 'volume': '66', 'author': 'Wood S.', 'year': '1958', 'journal-title': 'Arch. Path.'} / Arch. Path. / Pathogenesis of metastasis formation observed in vivo in the rabbit ear chamber by Wood S. (1958)

Dates

Type	When
Created	18 years, 6 months ago (Feb. 19, 2007, 12:08 p.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 1:18 a.m.)
Indexed	2 months, 1 week ago (June 27, 2025, 6:01 p.m.)
Issued	47 years, 2 months ago (June 15, 1978)
Published	47 years, 2 months ago (June 15, 1978)
Published Online	19 years, 1 month ago (July 17, 2006)
Published Print	47 years, 2 months ago (June 15, 1978)

Funders 0

None

BibTeX

@article{Glaves_1978, title={Initial tumor cell arrest in animals of defined coagulative status}, volume={21}, ISSN={1097-0215}, url={http://dx.doi.org/10.1002/ijc.2910210611}, DOI={10.1002/ijc.2910210611}, number={6}, journal={International Journal of Cancer}, publisher={Wiley}, author={Glaves, D. and Weiss, L.}, year={1978}, month=jun, pages={741–746} }

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