Establishment and characterization of a human histiocytic lymphoma cell line (U‐937)
10.1002/ijc.2910170504
Crossref journal-article
Wiley
International Journal of Cancer (311)
Abstract

AbstractA human hematopoietic cell line (U‐937) with exceptional characteristics was derived from a patient with generalized histiocytic lymphoma. The morphology of the cell line was identical to that of the tumor cells in the pleural effusion from which the line was derived. Since Epstein‐Barr virus (EBV) carrying diploid lymphoblastoid cell lines unrelated to the tumor population often become established in vitro from non‐Burkitt lymphoma explants, several parameters were studied to discriminate the U‐937 from such lines: morphology in vitro, growth characteristics, cytochemistry, surface receptor pattern, Ig production, lysozyme production, β2‐micro‐globulin production, presence of EBV genome and karyotype. In all these respects U‐937 differed from prototype lymphoblastoid cell lines. The histiocytic origin of the cell line was shown by its capacity for lysozyme production and the strong esterase activity (naphtol AS‐D acetate esterase inhibited by NaF) of the cells. It is therefore concluded that the U‐937 is a neoplastic, histiocytic cell line.

Bibliography

Sundström, C., & Nilsson, K. (1976). Establishment and characterization of a human histiocytic lymphoma cell line (U‐937). International Journal of Cancer, 17(5), 565–577. Portico.

Authors 2
  1. Christer Sundström (first)
  2. Kenneth Nilsson (additional)
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Dates
Type When
Created 18 years, 6 months ago (Feb. 19, 2007, 11:01 a.m.)
Deposited 1 year, 9 months ago (Nov. 12, 2023, 10:14 a.m.)
Indexed 49 minutes ago (Sept. 3, 2025, 4 a.m.)
Issued 49 years, 3 months ago (May 15, 1976)
Published 49 years, 3 months ago (May 15, 1976)
Published Online 19 years, 1 month ago (July 21, 2006)
Published Print 49 years, 3 months ago (May 15, 1976)
Funders 0

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@article{Sundstr_m_1976, title={Establishment and characterization of a human histiocytic lymphoma cell line (U‐937)}, volume={17}, ISSN={1097-0215}, url={http://dx.doi.org/10.1002/ijc.2910170504}, DOI={10.1002/ijc.2910170504}, number={5}, journal={International Journal of Cancer}, publisher={Wiley}, author={Sundström, Christer and Nilsson, Kenneth}, year={1976}, month=may, pages={565–577} }