DOI: 10.1002/ijc.22559. Prosurvival function of the granulin‐epithelin precursor is important in tumor progression and chemoresponse

Prosurvival function of the granulin‐epithelin precursor is important in tumor progression and chemoresponse

10.1002/ijc.22559

Crossref journal-article

Wiley

International Journal of Cancer (311)

Abstract

AbstractThe granulin‐epithelin precursor (GEP/PCDGF), a 68–88 kDa secreted glycoprotein, has been shown to be an important growth and survival factor for ovarian cancer cells. Furthermore, GEP expression is a predictor of patient survival in metastatic ovarian cancer cells. Up to this point, however, the molecular mechanisms and clinical relevance of a GEP‐mediated prosurvival phenotype remain poorly characterized. We hypothesize that the prosurvival function of GEP is important in ovarian cancer tumor progression and chemoresponse. To explore this hypothesis, we examined the effects of GEP overexpression on migration, invasion and cisplatin (CDDP) chemosensitivity in the ovarian cancer cell line A2780. Full length GEP transfectants demonstrated an increased capacity to migrate and invade their substratum when compared to empty vector controls. In addition, GEP overexpression was associated with CDDP chemoresistance. Finally, GEP overexpression increased tumor formation and protected cells from tumor regression in response to CDDP treatment in vivo. Taken together, these data support a role for GEP in tumor progression and development of drug resistance. © 2006 Wiley‐Liss, Inc.

Bibliography

Pizarro, G. O., Zhou, X. C., Koch, A., Gharib, M., Raval, S., Bible, K., & Jones, M. B. (2007). Prosurvival function of the granulinâepithelin precursor is important in tumor progression and chemoresponse. International Journal of Cancer, 120(11), 2339â2343. Portico.

Authors 7

Gresin O. Pizarro (first)
Xun Clare Zhou (additional)
Anthony Koch (additional)
Mahmood Gharib (additional)
Sejal Raval (additional)
Keith Bible (additional)
Monica B. Jones (additional)

References 19 Referenced 45

10.3322/canjclin.56.2.106
10.1056/NEJM199601043340101
10.1056/NEJMoa052985
10.1006/gyno.1998.4997
{'key': 'e_1_2_6_6_2', 'first-page': '44', 'article-title': 'The granulin‐epithelin precursor/PC‐cell‐derived growth factor is a growth factor for epithelial ovarian cancer', 'volume': '9', 'author': 'Jones MB', 'year': '2003', 'journal-title': 'Clin Cancer Res'} / Clin Cancer Res / The granulin‐epithelin precursor/PC‐cell‐derived growth factor is a growth factor for epithelial ovarian cancer by Jones MB (2003)
10.1006/gyno.2002.6704
10.1038/sj.onc.1208857
10.1002/cncr.20219
10.1006/excr.1997.3861
10.1210/en.2001-211408
{'key': 'e_1_2_6_12_2', 'first-page': '661', 'article-title': 'Characterization of an ovarian carcinoma cell line resistant to cisplatin and flavopiridol', 'volume': '6', 'author': 'Bible KC', 'year': '2000', 'journal-title': 'Clin Cancer Res'} / Clin Cancer Res / Characterization of an ovarian carcinoma cell line resistant to cisplatin and flavopiridol by Bible KC (2000)
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10.1158/1078-0432.CCR-05-0929
10.1158/1078-0432.CCR-05-2003
10.1158/0008-5472.CAN-06-0633
{'key': 'e_1_2_6_17_2', 'first-page': '5331', 'article-title': 'Biological activities and signaling pathways of the granulin/epithelin precursor', 'volume': '59', 'author': 'Zanocco‐Marani T', 'year': '1999', 'journal-title': 'Cancer Res'} / Cancer Res / Biological activities and signaling pathways of the granulin/epithelin precursor by Zanocco‐Marani T (1999)
10.1016/S0046-8177(03)00425-8
10.1158/0008-5472.CAN-03-2364
10.1158/1078-0432.CCR-05-2663

Dates

Type	When
Created	18 years, 7 months ago (Feb. 2, 2007, 11:46 p.m.)
Deposited	1 year, 10 months ago (Oct. 17, 2023, 12:10 a.m.)
Indexed	1 month ago (Aug. 6, 2025, 8:10 a.m.)
Issued	18 years, 5 months ago (March 27, 2007)
Published	18 years, 5 months ago (March 27, 2007)
Published Online	18 years, 5 months ago (March 27, 2007)
Published Print	18 years, 3 months ago (June 1, 2007)

Funders 0

None

BibTeX

@article{Pizarro_2007, title={Prosurvival function of the granulin‐epithelin precursor is important in tumor progression and chemoresponse}, volume={120}, ISSN={1097-0215}, url={http://dx.doi.org/10.1002/ijc.22559}, DOI={10.1002/ijc.22559}, number={11}, journal={International Journal of Cancer}, publisher={Wiley}, author={Pizarro, Gresin O. and Zhou, Xun Clare and Koch, Anthony and Gharib, Mahmood and Raval, Sejal and Bible, Keith and Jones, Monica B.}, year={2007}, month=mar, pages={2339–2343} }

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