DOI: 10.1002/hipo.450010403. Intragranular mossy fibers in rats and gerbils from synapses with the somata and proximal dendrites of basket cells in the dentate gyrus

Intragranular mossy fibers in rats and gerbils from synapses with the somata and proximal dendrites of basket cells in the dentate gyrus

10.1002/hipo.450010403

Crossref journal-article

Wiley

Hippocampus (311)

Abstract

AbstractIntragranular and supragranular mossy fibers arise from granule cells and are present in the dentate gyrus of hippocampi from kindled and epileptic animals. The intragranular fibers often appear as fibers perpendicular to the long axis of the granule cell layer at periodic intervals. Rats and gerbils were analyzed to determine whether such mossy fibers are also associated with nongranule cells (including the basket cells), which send their apical dendrites through this layer with a periodicity similar to that of mossy fibers. The results for rats and both epileptic and nonepileptic gerbils show that many intragranular mossy fibers are apposed to the surfaces of the somata and apical dendrites of basket cells where they form asymmetric synapses. This plexus of mossy fiber axons appears to follow the dendrites of these neurons into the inner molecular layer. Based on previous data indicating that basket cells are GABAergic inhibitory neurons, the present findings in normal rats and both types of gerbils suggest that intragranular and supragranular mossy fibers provide additional circuitry for feedback inhibition to granule cells. It is possible that under pathological conditions, such as denervation or kindling, these fibers sprout and form synapses with granule cells.

Bibliography

Ribak, C. E., & Peterson, G. M. (1991). Intragranular mossy fibers in rats and gerbils from synapses with the somata and proximal dendrites of basket cells in the dentate gyrus. Hippocampus, 1(4), 355â364. Portico.

Authors 2

Charles E. Ribak (first)
Gary M. Peterson (additional)

References 27 Referenced 99

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{'key': 'e_1_2_1_3_1', 'first-page': '881', 'article-title': 'Synaptic reorganization of mossy fibers into inner molecular layer in human epileptic fascia dentata', 'volume': '14', 'author': 'Babb T. L.', 'year': '1988', 'journal-title': 'Soc. Neurosci. Abstr.'} / Soc. Neurosci. Abstr. / Synaptic reorganization of mossy fibers into inner molecular layer in human epileptic fascia dentata by Babb T. L. (1988)
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Dates

Type	When
Created	20 years, 3 months ago (May 29, 2005, 8:20 a.m.)
Deposited	1 year, 10 months ago (Oct. 23, 2023, 2:15 a.m.)
Indexed	2 months, 3 weeks ago (June 12, 2025, 3:08 a.m.)
Issued	33 years, 11 months ago (Oct. 1, 1991)
Published	33 years, 11 months ago (Oct. 1, 1991)
Published Online	20 years, 10 months ago (Oct. 13, 2004)
Published Print	33 years, 11 months ago (Oct. 1, 1991)

Funders 0

None

BibTeX

@article{Ribak_1991, title={Intragranular mossy fibers in rats and gerbils from synapses with the somata and proximal dendrites of basket cells in the dentate gyrus}, volume={1}, ISSN={1098-1063}, url={http://dx.doi.org/10.1002/hipo.450010403}, DOI={10.1002/hipo.450010403}, number={4}, journal={Hippocampus}, publisher={Wiley}, author={Ribak, Charles E. and Peterson, Gary M.}, year={1991}, month=oct, pages={355–364} }

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