DOI: 10.1002/hep.1840150121. The acute-phase response protects mice from D-galactosamine sensitization to endotoxin and tumor necrosis factor-α

The acute-phase response protects mice from D-galactosamine sensitization to endotoxin and tumor necrosis factor-α

10.1002/hep.1840150121

Crossref journal-article

Ovid Technologies (Wolters Kluwer Health)

Hepatology (276)

Abstract

D-Galactosamine is an hepatocyte-specific inhibitor of RNA synthesis. It has been used to sensitize animals both to the lethal effects of bacterial endotoxin (lipopolysaccharide) and to a principal lipopolysaccharide-induced mediator of shock, tumor necrosis factor-α. The mechanism by which this sensitization occurs is unknown. Because lipopolysaccharide, acting through a network of cytokines, provokes the transcription of a number of hepatic acute-phase proteins, we postulated that the lipopolysaccharide-sensitizing effect of D-galactosamine could be caused by its inhibition of acute-phase product transcription. We confirmed that the acute-phase response to lipopolysaccharide was attenuated by simultaneous administration of D-galactosamine. However, when the acute-phase response was induced by subcutaneous turpentine 24 hr before D-galactosamine administration, the effect of D-galactosamine on circulating acute-phase reactants was negligible. Furthermore, induction of an a priori acute-phase response protected mice from both D-galactosamine/lipopolysaccharide and D-galactosamine/tumor necrosis factor-α-induced death. The turpentine-induced acute-phase response did not decrease endogenous tumor necrosis factor-α production after lipopolysaccharide, nor did it affect the clearance of larger doses of injected tumor necrosis factor-α. Thus we suggest that the acute-phase response protects against death in D-galactosamine—sensitized mice through an interaction with mediators of shock subsequent to tumor necrosis factor-α release. (Hepatology 1992;15:122-129).

Bibliography

Alcorn, J. M., Fierer, J., & Chojkier, M. (1992). The acute-phase response protects mice from D-galactosamine sensitization to endotoxin and tumor necrosis factor-Î±. Hepatology, 15(1), 122â129.

Authors 3

Joseph M. Alcorn (first)
Joshua Fierer (additional)
Mario Chojkier (additional)

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Dates

Type	When
Created	18 years, 5 months ago (March 3, 2007, 7:34 p.m.)
Deposited	8 months, 4 weeks ago (Dec. 1, 2024, 6:11 a.m.)
Indexed	2 months ago (June 27, 2025, 9:45 a.m.)
Issued	33 years, 7 months ago (Jan. 1, 1992)
Published	33 years, 7 months ago (Jan. 1, 1992)
Published Print	33 years, 7 months ago (Jan. 1, 1992)

Funders 0

None

BibTeX

@article{Alcorn_1992, title={The acute-phase response protects mice from D-galactosamine sensitization to endotoxin and tumor necrosis factor-α}, volume={15}, ISSN={0270-9139}, url={http://dx.doi.org/10.1002/hep.1840150121}, DOI={10.1002/hep.1840150121}, number={1}, journal={Hepatology}, publisher={Ovid Technologies (Wolters Kluwer Health)}, author={Alcorn, Joseph M. and Fierer, Joshua and Chojkier, Mario}, year={1992}, month=jan, pages={122–129} }

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