DOI: 10.1002/gepi.20124. The value of relatives with phenotypes but missing genotypes in association studies for quantitative traits

The value of relatives with phenotypes but missing genotypes in association studies for quantitative traits

10.1002/gepi.20124

Crossref journal-article

Wiley

Genetic Epidemiology (311)

Abstract

AbstractThe additional statistical power of association studies for quantitative traits was derived when ungenotyped relatives with phenotypes are included in the analysis. It was shown that the extra power is a simple function of the coefficient of additive genetic relationship and the phenotypic correlation coefficient between the genotyped and ungenotyped relatives. For close relatives, such as pairs of fullsibs and identical twin pairs, gains in power in the range of 10 to 30% are achieved if only one of the pair is genotyped. The theoretical results were verified by simulations. It was shown that ignoring the error in estimating the genotype of the ungenotyped relative has little impact on the estimates and on statistical power, consistent with results from quantitative trait loci (QTL) linkage studies. For genome‐wide association studies in which not all relatives with phenotypes can be genotyped, our study provides a prediction of the additional power of an analysis that includes phenotypes on ungenotyped individuals, and can be used in experimental design. We show that a two‐step procedure, in which missing genotypes are imputed and subsequently an association analysis is performed, is efficient and powerful. Genet. Epidemiol. 30:30–36, 2006. © 2005 Wiley‐Liss, Inc.

Bibliography

Visscher, P. M., & Duffy, D. L. (2005). The value of relatives with phenotypes but missing genotypes in association studies for quantitative traits. Genetic Epidemiology, 30(1), 30â36. Portico.

Authors 2

Peter M. Visscher (first)
David L. Duffy (additional)

References 20 Referenced 18

{'key': 'e_1_2_1_2_1', 'first-page': '676', 'article-title': 'Transmission‐disequilibrium tests for quantitative traits', 'volume': '60', 'author': 'Allison DB', 'year': '1997', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / Transmission‐disequilibrium tests for quantitative traits by Allison DB (1997)
10.1086/301844
10.1111/j.1469-1809.1986.tb01037.x
{'key': 'e_1_2_1_5_1', 'volume-title': 'Introduction to quantitative genetics', 'author': 'Falconer DS', 'year': '1996'} / Introduction to quantitative genetics by Falconer DS (1996)
10.1093/genetics/156.4.2081
{'key': 'e_1_2_1_7_1', 'first-page': '1382', 'article-title': 'Using the expectation or the distribution of the identity by descent for mapping quantitative trait loci under the random model', 'volume': '59', 'author': 'Gessler DD', 'year': '1996', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / Using the expectation or the distribution of the identity by descent for mapping quantitative trait loci under the random model by Gessler DD (1996)
10.1007/BF01066731
{'key': 'e_1_2_1_9_1', 'volume-title': 'Pedigree analysis package, Version 5.0', 'author': 'Hasstedt SJ', 'year': '2002'} / Pedigree analysis package, Version 5.0 by Hasstedt SJ (2002)
10.1002/gepi.1370060203
10.1093/genetics/164.2.637 / Genetics / Candidate gene analysis for quantitative traits using the transmission disequilibrium test: The example of the melanocortin 4‐receptor in pigs by Hernandez‐Sanchez J (2003)
10.1111/j.1439-0388.1996.tb00636.x
10.1093/genetics/134.1.351 / Genetics / A method of screening for genes of major effect by Kinghorn BP (1993)
10.1002/gepi.20073
10.1111/j.1469-1809.1976.tb00156.x
10.2307/2533114
{'key': 'e_1_2_1_17_1', 'volume-title': 'Genetics and analysis of quantitative traits', 'author': 'Lynch M', 'year': '1998'} / Genetics and analysis of quantitative traits by Lynch M (1998)
10.1006/tpbi.2001.1543
10.1046/j.1469-1809.2001.6560583.x
10.1186/1297-9686-37-5-403
10.1093/aje/148.7.623

Dates

Type	When
Created	19 years, 8 months ago (Dec. 14, 2005, 4:46 p.m.)
Deposited	1 year, 9 months ago (Nov. 15, 2023, 2:07 p.m.)
Indexed	2 months ago (June 27, 2025, 2:22 p.m.)
Issued	19 years, 8 months ago (Dec. 14, 2005)
Published	19 years, 8 months ago (Dec. 14, 2005)
Published Online	19 years, 8 months ago (Dec. 14, 2005)
Published Print	19 years, 7 months ago (Jan. 1, 2006)

Funders 0

None

BibTeX

@article{Visscher_2005, title={The value of relatives with phenotypes but missing genotypes in association studies for quantitative traits}, volume={30}, ISSN={1098-2272}, url={http://dx.doi.org/10.1002/gepi.20124}, DOI={10.1002/gepi.20124}, number={1}, journal={Genetic Epidemiology}, publisher={Wiley}, author={Visscher, Peter M. and Duffy, David L.}, year={2005}, month=dec, pages={30–36} }

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