DOI: 10.1002/gcc.2870100303. Detection of DNA amplification in 17 primary breast carcinomas with homogeneously staining regions by a modified comparative genomic hybridization technique

Detection of DNA amplification in 17 primary breast carcinomas with homogeneously staining regions by a modified comparative genomic hybridization technique

10.1002/gcc.2870100303

Crossref journal-article

Wiley

Genes, Chromosomes and Cancer (311)

Abstract

AbstractA modified comparative genomic hybridization (mCGH) technique was applied to a series of 17 primary breast carcinomas in which cytogenetic study (CG) demonstrated the presence of homogeneously staining region(s), suggesting the occurrence of DNA amplification. mCGH demonstrated recurrent amplifications of the whole chromosome arms 8q (9 times) and I q (7 times) and of DNA loci in the following bands: 11 q 13 (6 times), 9p 13 and 17q21.1 (4 times), I q21.1 and 16p 11.2 (3 times), and 8q22, 8q24.1, 10q22, 15q26, 17q23, and 20q 13.3 (twice). Amplification of whole chromosome arms is likely to have resulted from unbalanced translocations or isochromosomes, whereas amplifications of smaller chromosomal segments probably arose through real DNA amplification processes. In all tumors but one, more than one amplified locus was detected. The fact that many chromosomal sites were involved suggests that the process of amplification is complex and that many genes are potential targets. Genes Chromosom Cancer 10:160–170 (1994). © 1994 Wiley‐Liss, Inc.

Bibliography

Muleris, M., Almeida, A., GerbaultâSeureau, M., Malfoy, B., & Dutrillaux, B. (1994). Detection of DNA amplification in 17 primary breast carcinomas with homogeneously staining regions by a modified comparative genomic hybridization technique. Genes, Chromosomes and Cancer, 10(3), 160â170. Portico.

Authors 5

Martine Muleris (first)
Anna Almeida (additional)
Michèle Gerbault‐Seureau (additional)
Bernard Malfoy (additional)
Bernard Dutrillaux (additional)

References 30 Referenced 95

{'key': 'e_1_2_1_2_1', 'first-page': '659', 'article-title': 'BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers', 'volume': '6', 'author': 'Adnane J', 'year': '1991', 'journal-title': 'Oncogene'} / Oncogene / BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers by Adnane J (1991)
{'key': 'e_1_2_1_3_1', 'first-page': '1036', 'article-title': 'Sporadic amplification of the insulin‐like growth factor 1 receptor gene in human breast tumors', 'volume': '52', 'author': 'Berns EMJJ', 'year': '1992', 'journal-title': 'Cancer Res'} / Cancer Res / Sporadic amplification of the insulin‐like growth factor 1 receptor gene in human breast tumors by Berns EMJJ (1992)
{'key': 'e_1_2_1_4_1', 'first-page': '447', 'volume-title': 'The Causes and Consequences of Chromosomal Aberrations', 'author': 'Dutrillaux B', 'year': '1993'} / The Causes and Consequences of Chromosomal Aberrations by Dutrillaux B (1993)
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{'key': 'e_1_2_1_6_1', 'first-page': '138', 'article-title': 'Cytogenetic study of twelve human near‐diploid breast cancers with chromosomal changes', 'volume': '30', 'author': 'Gerbault‐Seureau M', 'year': '1987', 'journal-title': 'Ann Genet'} / Ann Genet / Cytogenetic study of twelve human near‐diploid breast cancers with chromosomal changes by Gerbault‐Seureau M (1987)
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{'key': 'e_1_2_1_9_1', 'volume-title': 'Guidelines for Cancer Cytogenetics, Supplement to An International System for Human Cytogenetic Nomenclature', 'author': 'Mitelman F.'} / Guidelines for Cancer Cytogenetics, Supplement to An International System for Human Cytogenetic Nomenclature by Mitelman F.
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Dates

Type	When
Created	18 years, 6 months ago (Feb. 21, 2007, 6:48 p.m.)
Deposited	1 year, 10 months ago (Oct. 24, 2023, 1:48 p.m.)
Indexed	1 month, 2 weeks ago (July 12, 2025, 6:52 p.m.)
Issued	31 years, 1 month ago (July 1, 1994)
Published	31 years, 1 month ago (July 1, 1994)
Published Online	19 years, 1 month ago (July 14, 2006)
Published Print	31 years, 1 month ago (July 1, 1994)

Funders 0

None

BibTeX

@article{Muleris_1994, title={Detection of DNA amplification in 17 primary breast carcinomas with homogeneously staining regions by a modified comparative genomic hybridization technique}, volume={10}, ISSN={1098-2264}, url={http://dx.doi.org/10.1002/gcc.2870100303}, DOI={10.1002/gcc.2870100303}, number={3}, journal={Genes, Chromosomes and Cancer}, publisher={Wiley}, author={Muleris, Martine and Almeida, Anna and Gerbault‐Seureau, Michèle and Malfoy, Bernard and Dutrillaux, Bernard}, year={1994}, month=jul, pages={160–170} }

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