DOI: 10.1002/gcc.2870070205. <i>PRAD1</i>/lCyclin D1 proto‐oncogene: Genomic organization, 5′ dna sequence, and sequence of a tumor‐specific rearrangement breakpoint

PRAD1/lCyclin D1 proto‐oncogene: Genomic organization, 5′ dna sequence, and sequence of a tumor‐specific rearrangement breakpoint

10.1002/gcc.2870070205

Crossref journal-article

Wiley

Genes, Chromosomes and Cancer (311)

Abstract

AbstractPRAD1 (previously D11S287) is a putative proto‐oncogene at 11q13, activated by overexpression through gene rearrangement or gene amplification in several types of human tumors including parathyroid adenomas, centrocytic lymphomas and other B‐cell tumors with t(11;14), and breast cancers. PRAD1 (also CCND1) encodes cyclin D1, which may regulate the G1‐S phase transition in the cell cycle. Here, we report the cloning and characterization of the chromosomal PRAD1/cyclin D1 gene and the sequence of its promoter region. The gene spans about 15 kb and has 5 exons; its promoter region has Sp 1 binding sites and no obvious TATA box, characteristics of housekeeping genes and growth‐regulating genes. Furthermore, an E2F binding motif present close to the major transcription start site may be involved in cell cycle‐dependent expression of this gene. We also report the sequence of DNAs spanning joining regions of a reciprocal parathyroid hormone/PRAD1 gene rearrangement in a parathyroid adenoma. Comparison with normal sequences suggests that the rearrangement was not a simple break‐and‐ligate event, but rather involved multiple steps, including two microdeletions and a microinversion. Very short sequences conserved near the breakpoints and symmetrical elements in the eventually inverted DNA segment might have played a role in this illegitimate complex recombination, which may have similarities with a constitutional translocation in Duchenne muscular dystrophy. © 1993 Wiley‐Liss, Inc.

Bibliography

Motokura, T., & Arnold, A. (1993). PRAD1/lCyclin D1 protoâoncogene: Genomic organization, 5â² dna sequence, and sequence of a tumorâspecific rearrangement breakpoint. Genes, Chromosomes and Cancer, 7(2), 89â95. Portico.

Authors 2

Toru Motokura (first)
Andrew Arnold (additional)

References 45 Referenced 127

10.1172/JCI114114
10.1126/science.3629260
10.1002/j.1460-2075.1989.tb08402.x
10.1073/pnas.86.13.5044
10.1038/355176a0
10.1093/nar/14.17.7071
10.1016/0092-8674(92)90215-X
10.1016/0092-8674(91)90625-9
10.1210/jcem-71-2-293
{'key': 'e_1_2_1_11_1', 'first-page': '725', 'article-title': 'Common sequence motifs at the rearrangement sites of a constitutional X/autosome translocation and associated deletion', 'volume': '50', 'author': 'Giacalone JP', 'year': '1992', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / Common sequence motifs at the rearrangement sites of a constitutional X/autosome translocation and associated deletion by Giacalone JP (1992)
10.1016/0168-9525(87)90155-7
{'key': 'e_1_2_1_13_1', 'first-page': '463', 'article-title': 'Characterization of intragenic deletions in two sporadic germinal mutation cases of retinoblastoma resulting in abnormal gene expression', 'volume': '6', 'author': 'Hashimoto T', 'year': '1991', 'journal-title': 'Oncogene'} / Oncogene / Characterization of intragenic deletions in two sporadic germinal mutation cases of retinoblastoma resulting in abnormal gene expression by Hashimoto T (1991)
10.1016/0092-8674(91)90028-W
10.1016/0888-7543(92)90126-D
10.1016/0092-8674(91)90044-Y
10.1007/BF00194629
{'key': 'e_1_2_1_18_1', 'first-page': '439', 'article-title': 'D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL‐1', 'volume': '6', 'author': 'Lammie GA', 'year': '1991', 'journal-title': 'Oncogene'} / Oncogene / D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL‐1 by Lammie GA (1991)
10.1016/0092-8674(91)90042-W
10.1073/pnas.80.9.2452
10.1016/0092-8674(91)90101-4
10.1016/0092-8674(89)90404-2
10.1016/S0959-437X(05)80334-X
10.1038/350512a0
10.1016/S0021-9258(19)88717-3
10.1159/000133359
10.1002/j.1460-2075.1990.tb07387.x
10.1016/0092-8674(91)90444-4
10.1016/0092-8674(91)90445-5
10.1016/0092-8674(90)90347-H
10.1038/310327a0
{'key': 'e_1_2_1_32_1', 'first-page': '99', 'article-title': 'Chromosome abnormalities at 11q13 in B cell tumours', 'volume': '3', 'author': 'Rabbitts PH', 'year': '1988', 'journal-title': 'Oncogene'} / Oncogene / Chromosome abnormalities at 11q13 in B cell tumours by Rabbitts PH (1988)
10.1007/BF00208924
{'key': 'e_1_2_1_34_1', 'first-page': '449', 'article-title': 'Rearrangement and overexpression of D11S287E, a candidate oncogene on chromosome 11q13 in benign parathyroid tumors', 'volume': '6', 'author': 'Rosenberg CL', 'year': '1991', 'journal-title': 'Oncogene'} / Oncogene / Rearrangement and overexpression of D11S287E, a candidate oncogene on chromosome 11q13 in benign parathyroid tumors by Rosenberg CL (1991)
10.1073/pnas.88.21.9638
10.1038/304181a0
{'key': 'e_1_2_1_37_1', 'first-page': '355', 'article-title': 'Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas', 'volume': '7', 'author': 'Schuuring E', 'year': '1992', 'journal-title': 'Oncogene'} / Oncogene / Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas by Schuuring E (1992)
10.1128/MCB.8.8.3160
{'key': 'e_1_2_1_39_1', 'first-page': '1401', 'article-title': 'Gene rearrangement and over‐expression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation', 'volume': '7', 'author': 'Seto M', 'year': '1992', 'journal-title': 'Oncogene'} / Oncogene / Gene rearrangement and over‐expression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation by Seto M (1992)
10.1016/0092-8674(92)90214-W
10.1126/science.6610211
10.1073/pnas.80.8.2127
{'key': 'e_1_2_1_43_1', 'first-page': '241', 'article-title': 'Chromosome 11 translocation breakpoints at the PRAD1/cyclin D1 gene locus in centrocytic lymphoma', 'volume': '7', 'author': 'Williams ME', 'year': '1993', 'journal-title': 'Leukemia'} / Leukemia / Chromosome 11 translocation breakpoints at the PRAD1/cyclin D1 gene locus in centrocytic lymphoma by Williams ME (1993)
10.1128/MCB.11.10.4846
10.1016/0092-8674(91)90100-D
10.1016/0888-7543(92)90127-E

Dates

Type	When
Created	18 years, 6 months ago (Feb. 21, 2007, 6:42 p.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 3:54 p.m.)
Indexed	1 year ago (Aug. 3, 2024, 4:19 p.m.)
Issued	32 years, 2 months ago (June 1, 1993)
Published	32 years, 2 months ago (June 1, 1993)
Published Online	19 years, 1 month ago (July 14, 2006)
Published Print	32 years, 2 months ago (June 1, 1993)

Funders 0

None

BibTeX

@article{Motokura_1993, title={PRAD1/lCyclin D1 proto‐oncogene: Genomic organization, 5′ dna sequence, and sequence of a tumor‐specific rearrangement breakpoint}, volume={7}, ISSN={1098-2264}, url={http://dx.doi.org/10.1002/gcc.2870070205}, DOI={10.1002/gcc.2870070205}, number={2}, journal={Genes, Chromosomes and Cancer}, publisher={Wiley}, author={Motokura, Toru and Arnold, Andrew}, year={1993}, month=jun, pages={89–95} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        8,
        3
      ]
    ],
    "date-time": "2024-08-03T20:19:56Z",
    "timestamp": 1722716396696
  },
  "reference-count": 45,
  "publisher": "Wiley",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2006,
            7,
            14
          ]
        ],
        "date-time": "2006-07-14T00:00:00Z",
        "timestamp": 1152835200000
      },
      "content-version": "vor",
      "delay-in-days": 4791,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1993,
        6
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title><jats:p><jats:italic>PRAD1</jats:italic> (previously D11S287) is a putative proto\u2010oncogene at 11q13, activated by overexpression through gene rearrangement or gene amplification in several types of human tumors including parathyroid adenomas, centrocytic lymphomas and other B\u2010cell tumors with t(11;14), and breast cancers. <jats:italic>PRAD1</jats:italic> (also <jats:italic>CCND1</jats:italic>) encodes cyclin D1, which may regulate the G1\u2010S phase transition in the cell cycle. Here, we report the cloning and characterization of the chromosomal <jats:italic>PRAD1</jats:italic>/cyclin D1 gene and the sequence of its promoter region. The gene spans about 15 kb and has 5 exons; its promoter region has Sp 1 binding sites and no obvious TATA box, characteristics of housekeeping genes and growth\u2010regulating genes. Furthermore, an E2F binding motif present close to the major transcription start site may be involved in cell cycle\u2010dependent expression of this gene. We also report the sequence of DNAs spanning joining regions of a reciprocal parathyroid hormone/<jats:italic>PRAD1</jats:italic> gene rearrangement in a parathyroid adenoma. Comparison with normal sequences suggests that the rearrangement was not a simple break\u2010and\u2010ligate event, but rather involved multiple steps, including two microdeletions and a microinversion. Very short sequences conserved near the breakpoints and symmetrical elements in the eventually inverted DNA segment might have played a role in this illegitimate complex recombination, which may have similarities with a constitutional translocation in Duchenne muscular dystrophy. \u00a9 1993 Wiley\u2010Liss, Inc.</jats:p>",
  "DOI": "10.1002/gcc.2870070205",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2007,
        2,
        21
      ]
    ],
    "date-time": "2007-02-21T23:42:12Z",
    "timestamp": 1172101332000
  },
  "page": "89-95",
  "source": "Crossref",
  "is-referenced-by-count": 127,
  "title": "<i>PRAD1</i>/lCyclin D1 proto\u2010oncogene: Genomic organization, 5\u2032 dna sequence, and sequence of a tumor\u2010specific rearrangement breakpoint",
  "prefix": "10.1002",
  "volume": "7",
  "author": [
    {
      "given": "Toru",
      "family": "Motokura",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Andrew",
      "family": "Arnold",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2006,
        7,
        14
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_2_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI114114"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.3629260"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1989.tb08402.x"
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.86.13.5044"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/355176a0"
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/14.17.7071"
    },
    {
      "key": "e_1_2_1_8_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90215-X"
    },
    {
      "key": "e_1_2_1_9_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(91)90625-9"
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/jcem-71-2-293"
    },
    {
      "key": "e_1_2_1_11_1",
      "first-page": "725",
      "article-title": "Common sequence motifs at the rearrangement sites of a constitutional X/autosome translocation and associated deletion",
      "volume": "50",
      "author": "Giacalone JP",
      "year": "1992",
      "journal-title": "Am J Hum Genet"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0168-9525(87)90155-7"
    },
    {
      "key": "e_1_2_1_13_1",
      "first-page": "463",
      "article-title": "Characterization of intragenic deletions in two sporadic germinal mutation cases of retinoblastoma resulting in abnormal gene expression",
      "volume": "6",
      "author": "Hashimoto T",
      "year": "1991",
      "journal-title": "Oncogene"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(91)90028-W"
    },
    {
      "key": "e_1_2_1_15_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0888-7543(92)90126-D"
    },
    {
      "key": "e_1_2_1_16_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(91)90044-Y"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00194629"
    },
    {
      "key": "e_1_2_1_18_1",
      "first-page": "439",
      "article-title": "D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL\u20101",
      "volume": "6",
      "author": "Lammie GA",
      "year": "1991",
      "journal-title": "Oncogene"
    },
    {
      "key": "e_1_2_1_19_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(91)90042-W"
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.80.9.2452"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(91)90101-4"
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(89)90404-2"
    },
    {
      "key": "e_1_2_1_23_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0959-437X(05)80334-X"
    },
    {
      "key": "e_1_2_1_24_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/350512a0"
    },
    {
      "key": "e_1_2_1_25_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(19)88717-3"
    },
    {
      "key": "e_1_2_1_26_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1159/000133359"
    },
    {
      "key": "e_1_2_1_27_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1990.tb07387.x"
    },
    {
      "key": "e_1_2_1_28_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(91)90444-4"
    },
    {
      "key": "e_1_2_1_29_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(91)90445-5"
    },
    {
      "key": "e_1_2_1_30_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(90)90347-H"
    },
    {
      "key": "e_1_2_1_31_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/310327a0"
    },
    {
      "key": "e_1_2_1_32_1",
      "first-page": "99",
      "article-title": "Chromosome abnormalities at 11q13 in B cell tumours",
      "volume": "3",
      "author": "Rabbitts PH",
      "year": "1988",
      "journal-title": "Oncogene"
    },
    {
      "key": "e_1_2_1_33_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00208924"
    },
    {
      "key": "e_1_2_1_34_1",
      "first-page": "449",
      "article-title": "Rearrangement and overexpression of D11S287E, a candidate oncogene on chromosome 11q13 in benign parathyroid tumors",
      "volume": "6",
      "author": "Rosenberg CL",
      "year": "1991",
      "journal-title": "Oncogene"
    },
    {
      "key": "e_1_2_1_35_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.88.21.9638"
    },
    {
      "key": "e_1_2_1_36_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/304181a0"
    },
    {
      "key": "e_1_2_1_37_1",
      "first-page": "355",
      "article-title": "Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas",
      "volume": "7",
      "author": "Schuuring E",
      "year": "1992",
      "journal-title": "Oncogene"
    },
    {
      "key": "e_1_2_1_38_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.8.8.3160"
    },
    {
      "key": "e_1_2_1_39_1",
      "first-page": "1401",
      "article-title": "Gene rearrangement and over\u2010expression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation",
      "volume": "7",
      "author": "Seto M",
      "year": "1992",
      "journal-title": "Oncogene"
    },
    {
      "key": "e_1_2_1_40_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90214-W"
    },
    {
      "key": "e_1_2_1_41_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.6610211"
    },
    {
      "key": "e_1_2_1_42_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.80.8.2127"
    },
    {
      "key": "e_1_2_1_43_1",
      "first-page": "241",
      "article-title": "Chromosome 11 translocation breakpoints at the PRAD1/cyclin D1 gene locus in centrocytic lymphoma",
      "volume": "7",
      "author": "Williams ME",
      "year": "1993",
      "journal-title": "Leukemia"
    },
    {
      "key": "e_1_2_1_44_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.11.10.4846"
    },
    {
      "key": "e_1_2_1_45_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(91)90100-D"
    },
    {
      "key": "e_1_2_1_46_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0888-7543(92)90127-E"
    }
  ],
  "container-title": "Genes, Chromosomes and Cancer",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fgcc.2870070205",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/gcc.2870070205",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        25
      ]
    ],
    "date-time": "2023-10-25T19:54:17Z",
    "timestamp": 1698263657000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1002/gcc.2870070205"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1993,
        6
      ]
    ]
  },
  "references-count": 45,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1993,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1002/gcc.2870070205"
  ],
  "URL": "http://dx.doi.org/10.1002/gcc.2870070205",
  "relation": {},
  "ISSN": [
    "1045-2257",
    "1098-2264"
  ],
  "subject": [],
  "container-title-short": "Genes Chromosomes &amp; Cancer",
  "published": {
    "date-parts": [
      [
        1993,
        6
      ]
    ]
  }
}