DOI: 10.1002/gcc.2870050416. Loss of heterozygosity on the long arm of chromosome 22 in pheochromocytoma

Loss of heterozygosity on the long arm of chromosome 22 in pheochromocytoma

10.1002/gcc.2870050416

Crossref journal-article

Wiley

Genes, Chromosomes and Cancer (311)

Abstract

AbstractTo identify the putative common deleted region on the long arm of chromosome 22 in pheochromocytoma, restriction fragment length polymorphism analysis was performed in 17 pheochromocytomas. All cases were heterozygous for at least one of the eight marker loci on 22q. Loss of heterozygosity (LOH) was observed in nine pheochromocytomas, of which eight were hereditary and one nonhereditary. Three pheochromocytomas had interstitial deletions that enabled us to localize the commonly deleted region as distal to D22S10 and proximal to D22S22. Hereditary pheochromocytoma frequently occurs in association with medullary thyroid carcinoma (MTC). Therefore, we also studied allelic loss on 22q in 23 hereditary MTCs. Only one of the MTCs showed LOH on 22q. Recent studies have mapped tumor suppressor loci associated with meningioma and neurofibromatosis type 2 (NF2) to 22q. The commonly deleted region in pheochromocytoma found by us encompasses the regions to which tumor suppressor genes associated with NF2 and meningioma have been mapped. The exact role of the pheochromocytoma tumor suppressor gene on 22q and its relationship to the suppressor genes involved in NF2 and meningioma remain unknown. © 1992 Wiley‐Liss, Inc.

Bibliography

Tanaka, N., Nishisho, I., Yamamoto, M., Miya, A., Shin, E., Karakawa, K., Fujita, S., Kobayashi, T., Rouleau, G. A., Mori, T., & Takai, S. (1992). Loss of heterozygosity on the long arm of chromosome 22 in pheochromocytoma. Genes, Chromosomes and Cancer, 5(4), 399â403. Portico.

Authors 11

Norifumi Tanaka (first)
Isamu Nishisho (additional)
Masayuki Yamamoto (additional)
Akihiro Miya (additional)
Eisei Shin (additional)
Katsu Karakawa (additional)
Shoichi Fujita (additional)
Tetsuro Kobayashi (additional)
Guy A. Rouleau (additional)
Takesada Mori (additional)
Shin‐Ichiro Takai (additional)

References 27 Referenced 32

{'key': 'e_1_2_1_2_1', 'first-page': '802', 'article-title': 'Occurrence of pheochromocytoma in Rochester, Minnesota, 1950 through 1979. May', 'volume': '58', 'author': 'Beard CM', 'year': '1983', 'journal-title': 'Clin Proc'} / Clin Proc / Occurrence of pheochromocytoma in Rochester, Minnesota, 1950 through 1979. May by Beard CM (1983)
10.1038/305779a0
{'key': 'e_1_2_1_4_1', 'first-page': '783', 'article-title': 'A t(4;22) in a meningioma points to the localization of a putative tumor‐suppressor gene', 'volume': '48', 'author': 'Deprez RHL', 'year': '1991', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / A t(4;22) in a meningioma points to the localization of a putative tumor‐suppressor gene by Deprez RHL (1991)
10.1073/pnas.84.24.9275
{'key': 'e_1_2_1_6_1', 'first-page': '5863', 'article-title': 'Molecular genetic analysis of chromosome 22 in 81 cases of meningioma', 'volume': '50', 'author': 'Dumanski JP', 'year': '1990', 'journal-title': 'Cancer Res'} / Cancer Res / Molecular genetic analysis of chromosome 22 in 81 cases of meningioma by Dumanski JP (1990)
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{'key': 'e_1_2_1_16_1', 'first-page': '4114', 'article-title': 'Low incidence of loss of chromosome 10 in sporadic and hereditary human medullary thyroid carcinoma', 'volume': '49', 'author': 'Nelkin BD', 'year': '1989', 'journal-title': 'Cancer Res'} / Cancer Res / Low incidence of loss of chromosome 10 in sporadic and hereditary human medullary thyroid carcinoma by Nelkin BD (1989)
10.1007/BF01870755
{'key': 'e_1_2_1_18_1', 'first-page': '15', 'article-title': 'Loss of genes on the long arm of chromosome 22 in human meningiomas', 'volume': '5', 'author': 'Okazaki M', 'year': '1988', 'journal-title': 'Mol Biol Med'} / Mol Biol Med / Loss of genes on the long arm of chromosome 22 in human meningiomas by Okazaki M (1988)
{'key': 'e_1_2_1_19_1', 'first-page': '112', 'article-title': 'Allele loss on chromosome 10 and point mutation of ras oncogenes are infrequent in tumors of MEN 2A', 'volume': '37', 'author': 'Okazaki M', 'year': '1989', 'journal-title': 'Henry Ford Hosp Med J'} / Henry Ford Hosp Med J / Allele loss on chromosome 10 and point mutation of ras oncogenes are infrequent in tumors of MEN 2A by Okazaki M (1989)
10.1016/0888-7543(89)90306-6
{'key': 'e_1_2_1_21_1', 'first-page': '323', 'article-title': 'Flanking markers bracket the neurofibromatosis type 2 (NF2) gene on chromosome 22', 'volume': '46', 'author': 'Rouleau GA', 'year': '1990', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / Flanking markers bracket the neurofibromatosis type 2 (NF2) gene on chromosome 22 by Rouleau GA (1990)
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{'key': 'e_1_2_1_25_1', 'first-page': '894', 'article-title': 'Loss of genes on chromosome 22 in medullary thyroid carcinoma and pheochromocytoma', 'volume': '78', 'author': 'Takai S', 'year': '1987', 'journal-title': 'Jpn J Cancer Res'} / Jpn J Cancer Res / Loss of genes on chromosome 22 in medullary thyroid carcinoma and pheochromocytoma by Takai S (1987)
10.1056/NEJM198809013190901
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10.1016/0888-7543(90)90463-5

Dates

Type	When
Created	18 years, 6 months ago (Feb. 21, 2007, 6:09 p.m.)
Deposited	1 year, 11 months ago (Sept. 26, 2023, 7:34 a.m.)
Indexed	1 month, 4 weeks ago (July 7, 2025, 2:28 a.m.)
Issued	32 years, 10 months ago (Nov. 1, 1992)
Published	32 years, 10 months ago (Nov. 1, 1992)
Published Online	19 years, 1 month ago (July 14, 2006)
Published Print	32 years, 10 months ago (Nov. 1, 1992)

Funders 0

None

BibTeX

@article{Tanaka_1992, title={Loss of heterozygosity on the long arm of chromosome 22 in pheochromocytoma}, volume={5}, ISSN={1098-2264}, url={http://dx.doi.org/10.1002/gcc.2870050416}, DOI={10.1002/gcc.2870050416}, number={4}, journal={Genes, Chromosomes and Cancer}, publisher={Wiley}, author={Tanaka, Norifumi and Nishisho, Isamu and Yamamoto, Masayuki and Miya, Akihiro and Shin, Eisei and Karakawa, Katsu and Fujita, Shoichi and Kobayashi, Tetsuro and Rouleau, Guy A. and Mori, Takesada and Takai, Shin‐Ichiro}, year={1992}, month=nov, pages={399–403} }

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