DOI: 10.1002/gcc.2870030403. Cytogenetics of papillary renal cell tumors

Cytogenetics of papillary renal cell tumors

10.1002/gcc.2870030403

Crossref journal-article

Wiley

Genes, Chromosomes and Cancer (311)

Abstract

AbstractChromosome aberrations were determined in short‐term cultures of 18 papillary renal cell tumors, as well as in the cell line ACHN, and the results were evaluated together with 20 previously published cases. We found that chromosomes 7, 17, and 16 and the Y chromosome were specifically involved in the karyotype changes in this tumor type. A combination of tri‐ or tetrasomy 7 and trisomy 17, as the only autosomal karyotype changes, marks benign papillary renal cell adenomas (ten cases). Malignant papillary renal cell carcinomas (29 cases) were characterized by additional trisomies: trisomy 16 occurred in 20 tumors, and trisomy 12 and 20 in 8 tumors each. Loss of the Y chromosome was observed in 7 of 9 benign and in 23 of 25 malignant tumors that developed in males. None of the papillary renal cell adenomas or carcinomas showed a loss of 3p or gain of a 5q segment, both of which are characteristic of common non‐papillary renal cell carcinomas.

Bibliography

Kovacs, G., Fuzesi, L., Emanuel, A., & Kung, H. (1991). Cytogenetics of papillary renal cell tumors. Genes, Chromosomes and Cancer, 3(4), 249â255. Portico.

Authors 4

Gyula Kovacs (first)
Laszlo Fuzesi (additional)
Angela Emanuel (additional)
Hsiang‐Fu Kung (additional)

References 33 Referenced 264

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Dates

Type	When
Created	18 years, 6 months ago (Feb. 21, 2007, 5:50 p.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 8:18 p.m.)
Indexed	34 minutes ago (Aug. 29, 2025, 3:32 a.m.)
Issued	34 years, 1 month ago (July 1, 1991)
Published	34 years, 1 month ago (July 1, 1991)
Published Online	19 years, 1 month ago (July 14, 2006)
Published Print	34 years, 1 month ago (July 1, 1991)

Funders 0

None

BibTeX

@article{Kovacs_1991, title={Cytogenetics of papillary renal cell tumors}, volume={3}, ISSN={1098-2264}, url={http://dx.doi.org/10.1002/gcc.2870030403}, DOI={10.1002/gcc.2870030403}, number={4}, journal={Genes, Chromosomes and Cancer}, publisher={Wiley}, author={Kovacs, Gyula and Fuzesi, Laszlo and Emanuel, Angela and Kung, Hsiang‐Fu}, year={1991}, month=jul, pages={249–255} }

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