The 11q13 amplicon of a mammary carcinoma cell line
10.1002/gcc.2870020302
Crossref journal-article
Wiley
Genes, Chromosomes and Cancer (311)
Abstract

AbstractFifteen to 20% of breast carcinomas show amplification of genes located at 11q13. The HST/FGFK and INT2 fibroblast growth factor (FGF)‐related genes and the BCL1 locus are usually present in the amplification units. We have investigated the structure and chromosomal location of the 11q13 amplicon of the MDA‐MB‐134 mammary carcinoma cell line by using in situ chromosomal and pulsed field gel hybridizations. The results indicate that a limited number of amplification units are involved in the constitution of an extended chromosomal region located on 11q. These units do not show any important rearrangement over rather large distances around the HST/INT2 and BCL1 loci.

Bibliography

Lafage, M., Nguyen, C., Szepetowski, P., Pébusque, M., Simonetti, J., Courtois, G., Gaudray, P., Delapeyriere, O., Jordan, B., & Birnbaum, D. (1990). The 11q13 amplicon of a mammary carcinoma cell line. Genes, Chromosomes and Cancer, 2(3), 171–181. Portico.

Authors 10
  1. Marina Lafage (first)
  2. Catherine Nguyen (additional)
  3. Pierre Szepetowski (additional)
  4. Marie‐Josèphe Pébusque (additional)
  5. Jacqueline Simonetti (additional)
  6. Geneviéve Courtois (additional)
  7. Patrick Gaudray (additional)
  8. Odile Delapeyriere (additional)
  9. Bertrand Jordan (additional)
  10. Daniel Birnbaum (additional)
References 50 Referenced 19
  1. {'key': 'e_1_2_1_2_1', 'first-page': '413', 'article-title': 'Chromosomal localization of the hst oncogene and its co‐amplification with the int‐2 oncogene in a human melanoma', 'volume': '2', 'author': 'Adelaide J', 'year': '1988', 'journal-title': 'Oncogene'} / Oncogene / Chromosomal localization of the hst oncogene and its co‐amplification with the int‐2 oncogene in a human melanoma by Adelaide J (1988)
  2. {'key': 'e_1_2_1_3_1', 'first-page': '1389', 'article-title': 'Proto‐oncogene amplification and human breast tumor phenotype', 'volume': '4', 'author': 'Adnane J', 'year': '1989', 'journal-title': 'Oncogene'} / Oncogene / Proto‐oncogene amplification and human breast tumor phenotype by Adnane J (1989)
  3. {'key': 'e_1_2_1_4_1', 'first-page': '89', 'article-title': 'The amplification unit on chromosome 11q13 in aggressive primary human breast tumors entails the bcl‐1, int‐2 and hst loci', 'volume': '4', 'author': 'Ali IU', 'year': '1989', 'journal-title': 'Oncogene'} / Oncogene / The amplification unit on chromosome 11q13 in aggressive primary human breast tumors entails the bcl‐1, int‐2 and hst loci by Ali IU (1989)
  4. 10.1128/MCB.9.11.4903
  5. {'key': 'e_1_2_1_6_1', 'first-page': '212', 'article-title': 'Biology of the fibroblast growth factor gene family', 'volume': '26', 'author': 'Benharroch D', 'year': '1990', 'journal-title': 'Israel J Med Sci'} / Israel J Med Sci / Biology of the fibroblast growth factor gene family by Benharroch D (1990)
  6. 10.1126/science.942798
  7. 10.1002/jcb.240340404
  8. 10.1016/0165-4608(89)90243-4
  9. 10.1093/jnci/53.3.661
  10. 10.1128/MCB.6.2.502
  11. 10.1073/pnas.84.16.5660
  12. 10.1016/0092-8674(84)90383-0
  13. 10.1073/pnas.85.23.9258
  14. 10.1073/pnas.83.13.4834
  15. {'key': 'e_1_2_1_16_1', 'first-page': '283', 'volume-title': 'Cancer Cells', 'author': 'Fand V', 'year': '1989'} / Cancer Cells by Fand V (1989)
  16. 10.1093/nar/13.5.1431
  17. 10.1159/000132417
  18. {'key': 'e_1_2_1_19_1', 'first-page': '1012', 'article-title': 'Leu 1 (CD5) cell surface antigen mapped to 11q13 by in situ hybridization', 'volume': '51', 'author': 'Hecht B', 'year': '1989', 'journal-title': 'Cytogenet Cell Genet'} / Cytogenet Cell Genet / Leu 1 (CD5) cell surface antigen mapped to 11q13 by in situ hybridization by Hecht B (1989)
  19. ISCN(1985) An International System for Human Cytogenetic Nomenclature. Harnden DG Klinger HP (eds). Cytogenet Cell Genet.
  20. 10.1182/blood.V73.1.104.104 / Blood / The human interleukin‐1 alpha is located on the long arm of chromosome 2 at band q13 by Lafage M (1989)
  21. 10.1038/313144a0
  22. {'key': 'e_1_2_1_23_1', 'first-page': '285', 'article-title': 'Amplification of the int‐2 gene in primary human breast tumors', 'volume': '2', 'author': 'Lidereau R', 'year': '1988', 'journal-title': 'Oncogene Res'} / Oncogene Res / Amplification of the int‐2 gene in primary human breast tumors by Lidereau R (1988)
  23. {'key': 'e_1_2_1_24_1', 'first-page': '1219', 'article-title': 'Expression of int‐2 mRNA in human tumors amplified at the int‐2 locus', 'volume': '4', 'author': 'Liscia D', 'year': '1989', 'journal-title': 'Oncogene'} / Oncogene / Expression of int‐2 mRNA in human tumors amplified at the int‐2 locus by Liscia D (1989)
  24. {'key': 'e_1_2_1_25_1', 'first-page': '335', 'article-title': 'Characterization of the HST‐relaed FGF‐6 gene, a new member of the fibroblast growth factor gene family', 'volume': '4', 'author': 'Marics I', 'year': '1989', 'journal-title': 'Oncogene'} / Oncogene / Characterization of the HST‐relaed FGF‐6 gene, a new member of the fibroblast growth factor gene family by Marics I (1989)
  25. {'key': 'e_1_2_1_26_1', 'first-page': '658', 'article-title': 'Assignment of the human progesterone receptor to the q22 band of chromosome 11 using in situ hybridization', 'volume': '46', 'author': 'Mattei MG', 'year': '1987', 'journal-title': 'Cytogenet Cell Genet'} / Cytogenet Cell Genet / Assignment of the human progesterone receptor to the q22 band of chromosome 11 using in situ hybridization by Mattei MG (1987)
  26. 10.1002/j.1460-2075.1987.tb02647.x
  27. {'key': 'e_1_2_1_28_1', 'first-page': '703', 'article-title': 'The FGF‐related oncogenes hst and int‐2, and the bcl‐1 locus are contained within one megabase in band q13 of chromosome 11, while the fgf‐5 oncogene maps to 4q21', 'volume': '3', 'author': 'Nguyen C', 'year': '1988', 'journal-title': 'Oncogene'} / Oncogene / The FGF‐related oncogenes hst and int‐2, and the bcl‐1 locus are contained within one megabase in band q13 of chromosome 11, while the fgf‐5 oncogene maps to 4q21 by Nguyen C (1988)
  28. 10.1038/306494a0
  29. {'key': 'e_1_2_1_30_1', 'first-page': '96', 'article-title': 'Near‐diploid tumor cell lines for cancer research', 'volume': '1', 'author': 'Parsons D', 'year': '1989', 'journal-title': 'Cancer Cells'} / Cancer Cells / Near‐diploid tumor cell lines for cancer research by Parsons D (1989)
  30. 10.1073/pnas.86.15.5678
  31. 10.1073/pnas.83.11.3997
  32. 10.1038/305245a0
  33. 10.1002/gcc.2870010302
  34. 10.1073/pnas.81.15.4940
  35. {'key': 'e_1_2_1_36_1', 'first-page': '5297', 'article-title': 'Amplification and rearrangement of DNA sequences from the chromosomal region 2p24 in human neuroblastomas', 'volume': '46', 'author': 'Shiloh Y', 'year': '1986', 'journal-title': 'Cancer Res'} / Cancer Res / Amplification and rearrangement of DNA sequences from the chromosomal region 2p24 in human neuroblastomas by Shiloh Y (1986)
  36. 10.1126/science.3798106
  37. 10.1016/0092-8674(89)90328-0
  38. {'key': 'e_1_2_1_39_1', 'first-page': '289', 'volume-title': 'Cancer Cells', 'author': 'Theillet C', 'year': '1989'} / Cancer Cells by Theillet C (1989)
  39. {'key': 'e_1_2_1_40_1', 'first-page': '147', 'article-title': 'BCL‐1 participates in the 11q13 amplification found in breast cancer', 'volume': '5', 'author': 'Theillet C', 'year': '1990', 'journal-title': 'Oncogene'} / Oncogene / BCL‐1 participates in the 11q13 amplification found in breast cancer by Theillet C (1990)
  40. {'key': 'e_1_2_1_41_1', 'first-page': '915', 'article-title': 'Amplification of FGF‐related genes in human tumors: Possible involvement of HST in breast carcinomas', 'volume': '4', 'author': 'Theillet C', 'year': '1989', 'journal-title': 'Oncogene'} / Oncogene / Amplification of FGF‐related genes in human tumors: Possible involvement of HST in breast carcinomas by Theillet C (1989)
  41. 10.1007/BF01806017
  42. {'key': 'e_1_2_1_43_1', 'first-page': '5505', 'article-title': 'High incidence of coamplification of hst‐1 and int‐2 genes in human esophageal carcinomas', 'volume': '49', 'author': 'Tsuda T', 'year': '1989', 'journal-title': 'Cancer Res'} / Cancer Res / High incidence of coamplification of hst‐1 and int‐2 genes in human esophageal carcinomas by Tsuda T (1989)
  43. 10.1038/315340a0
  44. {'key': 'e_1_2_1_45_1', 'first-page': '87', 'article-title': 'A common alteration to the int‐2 proto‐oncogene in DNA from primary breast carcinomas', 'volume': '3', 'author': 'Varley J', 'year': '1988', 'journal-title': 'Oncogene'} / Oncogene / A common alteration to the int‐2 proto‐oncogene in DNA from primary breast carcinomas by Varley J (1988)
  45. {'key': 'e_1_2_1_46_1', 'first-page': '1333', 'article-title': 'The importance of circular DNA in mammalian gene amplification', 'volume': '49', 'author': 'Wahl G', 'year': '1989', 'journal-title': 'Cancer Res'} / Cancer Res / The importance of circular DNA in mammalian gene amplification by Wahl G (1989)
  46. {'key': 'e_1_2_1_47_1', 'first-page': '345', 'article-title': 'A human sequence homologous to v‐sea maps to chromosome 11, band q13', 'volume': '3', 'author': 'Williams B', 'year': '1988', 'journal-title': 'Oncogene'} / Oncogene / A human sequence homologous to v‐sea maps to chromosome 11, band q13 by Williams B (1988)
  47. {'key': 'e_1_2_1_48_1', 'first-page': '607', 'article-title': 'Heterogeneity of lung cancer cells with respect to the amplification and rearrangement of myc family oncogenes', 'volume': '2', 'author': 'Yokota J', 'year': '1988', 'journal-title': 'Oncogene'} / Oncogene / Heterogeneity of lung cancer cells with respect to the amplification and rearrangement of myc family oncogenes by Yokota J (1988)
  48. 10.1016/S0006-291X(88)80295-X
  49. 10.1128/MCB.8.2.522
  50. {'key': 'e_1_2_1_51_1', 'first-page': '279', 'article-title': 'Amplification of human int‐2 in breast cancers and squamous carcinomas', 'volume': '2', 'author': 'Zhou D', 'year': '1988', 'journal-title': 'Oncogene'} / Oncogene / Amplification of human int‐2 in breast cancers and squamous carcinomas by Zhou D (1988)
Dates
Type When
Created 18 years, 6 months ago (Feb. 21, 2007, 5:52 p.m.)
Deposited 1 year, 10 months ago (Oct. 22, 2023, 3:13 a.m.)
Indexed 1 year, 10 months ago (Oct. 25, 2023, 4:25 p.m.)
Issued 35 years ago (Sept. 1, 1990)
Published 35 years ago (Sept. 1, 1990)
Published Online 19 years, 1 month ago (July 14, 2006)
Published Print 35 years ago (Sept. 1, 1990)
Funders 0

None

@article{Lafage_1990, title={The 11q13 amplicon of a mammary carcinoma cell line}, volume={2}, ISSN={1098-2264}, url={http://dx.doi.org/10.1002/gcc.2870020302}, DOI={10.1002/gcc.2870020302}, number={3}, journal={Genes, Chromosomes and Cancer}, publisher={Wiley}, author={Lafage, Marina and Nguyen, Catherine and Szepetowski, Pierre and Pébusque, Marie‐Josèphe and Simonetti, Jacqueline and Courtois, Geneviéve and Gaudray, Patrick and Delapeyriere, Odile and Jordan, Bertrand and Birnbaum, Daniel}, year={1990}, month=sep, pages={171–181} }