DOI: 10.1002/gcc.2870010104. Characteristic karyotypic anomalies identify subtypes of malignant fibrous histiocytoma

Characteristic karyotypic anomalies identify subtypes of malignant fibrous histiocytoma

10.1002/gcc.2870010104

Crossref journal-article

Wiley

Genes, Chromosomes and Cancer (311)

Abstract

AbstractCytogenetic analysis of short‐term cultures from 25 malignant fibrous histiocytomas (MFH) revealed clonal chromosome abnormalities in 17 tumors: ten storiform‐pleomorphic and seven myxoid MFH. Telomeric associations, rings, and dicentric chromosomes were present in 11 tumors and cytogenetic signs of gene amplification (homogeneously staining regions and double minute chromosomes) in four. The breakpoint distribution of the numerous structural rearrangements was nonrandom. The chromosome bands most frequently affected were 19p13 (in eight tumors; eight rearrangements gave rise to 19p+ markers, some of which looked similar, and an r(19) was found in one case), 11p11 (in seven tumors; three translocations and four deletions), 1q11 (in seven tumors; one translocation and six deletions), and 3p12 (in six tumors; all deletions). Other bands involved at least four times were 1p36, 5p15, and 20q13. Of particular clinical interest was the observation that tumors with 19p+ seemed to have a pronounced tendency to recur locally (local recurrence in five of eight tumors with 19p+ compared to one of nine in tumors without this aberration; observation period 4–16 months).

Bibliography

Mandahl, N., Heim, S., WillÃ©n, H., Rydholm, A., Eneroth, M., Nilbert, M., Kreicbergs, A., & Mitelman, F. (1989). Characteristic karyotypic anomalies identify subtypes of malignant fibrous histiocytoma. Genes, Chromosomes and Cancer, 1(1), 9â14. Portico.

Authors 8

Nils Mandahl (first)
Sverre Heim (additional)
Helena Willén (additional)
Anders Rydholm (additional)
Magnus Eneroth (additional)
Mef Nilbert (additional)
Andris Kreicbergs (additional)
Felix Mitelman (additional)

References 16 Referenced 96

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10.1016/0165-4608(87)90035-5
{'key': 'e_1_2_1_4_1', 'volume-title': 'Soft Tissue Tumors', 'author': 'Enzinger FM', 'year': '1988'} / Soft Tissue Tumors by Enzinger FM (1988)
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10.1038/bjc.1988.176
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{'key': 'e_1_2_1_8_1', 'first-page': '1', 'article-title': 'A two‐mutation model for human cancer', 'volume': '7', 'author': 'Knudson AG', 'year': '1987', 'journal-title': 'Adv Viral Oncol'} / Adv Viral Oncol / A two‐mutation model for human cancer by Knudson AG (1987)
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{'key': 'e_1_2_1_12_1', 'volume-title': 'Catalog of Chromosome Aberrations in Cancer', 'author': 'Mitelman F', 'year': '1988'} / Catalog of Chromosome Aberrations in Cancer by Mitelman F (1988)
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10.1126/science.3873110

Dates

Type	When
Created	18 years, 6 months ago (Feb. 21, 2007, 5:38 p.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 1:56 a.m.)
Indexed	4 days, 4 hours ago (Sept. 3, 2025, 6:35 a.m.)
Issued	36 years ago (Sept. 1, 1989)
Published	36 years ago (Sept. 1, 1989)
Published Online	19 years, 1 month ago (July 14, 2006)
Published Print	36 years ago (Sept. 1, 1989)

Funders 0

None

BibTeX

@article{Mandahl_1989, title={Characteristic karyotypic anomalies identify subtypes of malignant fibrous histiocytoma}, volume={1}, ISSN={1098-2264}, url={http://dx.doi.org/10.1002/gcc.2870010104}, DOI={10.1002/gcc.2870010104}, number={1}, journal={Genes, Chromosomes and Cancer}, publisher={Wiley}, author={Mandahl, Nils and Heim, Sverre and Willén, Helena and Rydholm, Anders and Eneroth, Magnus and Nilbert, Mef and Kreicbergs, Andris and Mitelman, Felix}, year={1989}, month=sep, pages={9–14} }

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