DOI: 10.1002/etc.5620220126. Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (<i>Oncorhynchus mykiss</i>)

Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (Oncorhynchus mykiss)

10.1002/etc.5620220126

Crossref journal-article

Oxford University Press (OUP)

Environmental Toxicology and Chemistry (286)

Abstract

AbstractRainbow trout (Oncorhynchus mykiss) were exposed simultaneously to a homologous series of perfluoroalkyl carboxylates and sulfonates in a flow-through system to determine compound-specific tissue distribution and bioconcentration parameters for perfluorinated acids (PFAs). In general, PFAs accumulated to the greatest extent in blood &gt; kidney &gt; liver &gt; gall bladder. Carboxylates and sulfonates with perfluoroalkyl chain lengths shorter than seven and six carbons, respectively, could not be detected in most tissues and were considered to have insignificant bioconcentration factors (BCFs). For detectable PFAs, carcass BCFs increased with increasing length of the perfluoroalkyl chain, ranging from 4.0 to 23,000, based on wet weight concentrations. Carboxylate carcass BCFs increased by a factor of eight for each additional carbon in the perfluoroalkyl chain between 8 and 12 carbons, but this relationship deviated from linearity for the longest PFA tested, possibly because of decreased gill permeability. In general, half-lives (3.9–28 d) and uptake rates (0.053–1,700 L/kg/d) also increased with increasing length of the perfluoroalkyl chain in all tissues. Sulfonates had greater BCFs, half-lives, and rates of uptake than the corresponding carboxylate of equal perfluoroalkyl chain length, indicating that hydrophobicity, as predicted by the critical micelle concentration, is not the only determinant of PFA bioaccumulation potential and that the acid function must be considered.

Bibliography

Martin, J. W., Mabury, S. A., Solomon, K. R., & Muir, D. C. G. (2003). Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (Oncorhynchus mykiss). Environmental Toxicology and Chemistry, 22(1), 196â204.

Authors 4

Jonathan W. Martin (first)
Scott A. Mabury (additional)
Keith R. Solomon (additional)
Derek C. G. Muir (additional)

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Dates

Type	When
Created	15 years, 5 months ago (March 17, 2010, 7:18 p.m.)
Deposited	6 months, 2 weeks ago (Feb. 19, 2025, 9:54 a.m.)
Indexed	14 hours, 59 minutes ago (Sept. 6, 2025, 3:50 p.m.)
Issued	22 years, 8 months ago (Jan. 1, 2003)
Published	22 years, 8 months ago (Jan. 1, 2003)
Published Online	22 years, 8 months ago (Jan. 1, 2003)
Published Print	22 years, 8 months ago (Jan. 1, 2003)

Funders 0

None

BibTeX

@article{Martin_2003, title={Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (Oncorhynchus mykiss)}, volume={22}, ISSN={1552-8618}, url={http://dx.doi.org/10.1002/etc.5620220126}, DOI={10.1002/etc.5620220126}, number={1}, journal={Environmental Toxicology and Chemistry}, publisher={Oxford University Press (OUP)}, author={Martin, Jonathan W. and Mabury, Scott A. and Solomon, Keith R. and Muir, Derek C. G.}, year={2003}, month=jan, pages={196–204} }

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