DOI: 10.1002/ejic.201000496. Nanoscale Metal–Organic Frameworks: Magnetic Resonance Imaging Contrast Agents and Beyond

Nanoscale Metal–Organic Frameworks: Magnetic Resonance Imaging Contrast Agents and Beyond

10.1002/ejic.201000496

Crossref journal-article

Wiley

European Journal of Inorganic Chemistry (311)

Abstract

AbstractMagnetic resonance imaging (MRI) is an imaging technique based on the detection of nuclear spin reorientations in a magnetic field. MRI provides high spatial resolution and soft‐tissue contrast in anatomical images, and a large penetration depth; however, it is relatively insensitive and typically relies on large doses of administered contrast agents to give adequate contrast between normal and diseased tissues. This review covers the development of nanoscale metal–organic frameworks (NMOFs) as novel MRI contrast agents. NMOFs not only provide an effective vehicle for delivering large amounts of paramagnetic metal centers but also exhibit enhanced per‐metal‐based relaxivity relative to clinically used small‐molecule contrast agents. The in vitro and in vivo effectiveness of these agents has also been demonstrated. The potential of NMOFs as contrast agents for other imaging modalities, such as optical imaging (OI) and X‐ray computed tomography (CT), and as chemical and biological sensors is also discussed.

Bibliography

Della Rocca, J., & Lin, W. (2010). Nanoscale MetalâOrganic Frameworks: Magnetic Resonance Imaging Contrast Agents and Beyond. European Journal of Inorganic Chemistry, 2010(24), 3725â3734. Portico.

Authors 2

Joseph Della Rocca (first)
Wenbin Lin (additional)

References 72 Referenced 188

Dates

Type	When
Created	15 years, 1 month ago (July 13, 2010, 12:19 p.m.)
Deposited	2 years ago (Sept. 2, 2023, 1:53 a.m.)
Indexed	1 day, 16 hours ago (Sept. 4, 2025, 9:54 a.m.)
Issued	15 years, 1 month ago (July 7, 2010)
Published	15 years, 1 month ago (July 7, 2010)
Published Online	15 years, 1 month ago (July 7, 2010)
Published Print	15 years, 1 month ago (Aug. 1, 2010)

Funders 0

None

BibTeX

@article{Della_Rocca_2010, title={Nanoscale Metal–Organic Frameworks: Magnetic Resonance Imaging Contrast Agents and Beyond}, volume={2010}, ISSN={1099-0682}, url={http://dx.doi.org/10.1002/ejic.201000496}, DOI={10.1002/ejic.201000496}, number={24}, journal={European Journal of Inorganic Chemistry}, publisher={Wiley}, author={Della Rocca, Joseph and Lin, Wenbin}, year={2010}, month=jul, pages={3725–3734} }

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