DOI: 10.1002/eji.1830251024. CD30 ligation induces nuclear factor‐ϰB activation in human T cell lines

CD30 ligation induces nuclear factor‐ϰB activation in human T cell lines

10.1002/eji.1830251024

Crossref journal-article

Wiley

European Journal of Immunology (311)

Abstract

AbstractCD30 is a recently described member of the tumor necrosis factor/nerve growth factor receptor superfamily. In this report, we show that following incubation of L540 cells (Hodgkin's disease‐derived, T cell‐like, CD30+ cells) with the agonistic anti‐CD30 monoclonal antibodies (mAb) M44 and M67, two nuclear factor (NF)‐ϰB DNA binding activities were induced in nuclear extracts, as determined in gel retardation assays. The effect of the mAb towards NF‐ϰB activation was rapid, as it occurred within 20 min, and was sustained for up to 6h. By comparison, an isotype‐matched antibody had no effect on NF‐ϰB activation. Moreover, in human T helper (Th) clones functionally characterized as being of the type 0, type 1 and type 2 (28%, < 1% und 93% CD30+, respectively), the extent of CD30‐mediated NF‐ϰB activation correlated with the proportion of CD30+ cells. In all cell lines investigated, the NF‐ϰB complexes induced following CD30 engagement were shown to contain p50 NF‐ϰB1, p65 RelA, and possibly other transcription factors. Collectively, our results demonstrate that nuclear translocation and activation of NF‐ϰB rank among the short‐term cellular responses elicited following CD30 ligation.

Bibliography

McDonald, P. P., Cassatella, M. A., Bald, A., Maggi, E., Romagnani, S., Gruss, H., & Pizzolo, G. (1995). CD30 ligation induces nuclear factorâÏ°B activation in human T cell lines. European Journal of Immunology, 25(10), 2870â2876. Portico.

Authors 7

Patrick P. McDonald (first)
Marco A. Cassatella (additional)
Anette Bald (additional)
Enrico Maggi (additional)
Sergio Romagnani (additional)
Hans‐Jürgen Gruss (additional)
Giovanni Pizzolo (additional)

References 31 Referenced 48

10.1038/299065a0
10.1182/blood.V66.4.848.848 / Blood by Stein H. (1985)
10.1182/blood.V63.6.1299.1299 / Blood by Andreesen R. (1984)
10.4049/jimmunol.151.5.2380 / J. Immunol. by Ellis T. M. (1993)
10.1096/fasebj.9.1.7821763
10.1084/jem.180.6.2407
10.1182/blood.V83.8.2045.2045 / Blood by Gruss H.‐J. (1994)
Gruss H.‐J. Hirschstein D. Alderson M. R.andArmitage R. J. J. Immunol.1995: in press.
10.1016/0092-8674(92)90180-K
10.1016/0092-8674(93)90361-S
10.1146/annurev.iy.12.040194.001041
10.1073/pnas.86.7.2336
10.1073/pnas.86.15.5974
10.1073/pnas.86.7.2365
10.1002/j.1460-2075.1993.tb06157.x
10.1016/0092-8674(92)90353-E
10.1007/BF00405072
10.1093/nar/11.5.1475
10.1016/0092-8674(88)90382-0
10.1073/pnas.72.7.2626
10.4049/jimmunol.146.7.2409 / J. Immunol. by Hémar A. (1991)
10.1073/pnas.82.20.6932
10.4049/jimmunol.153.10.4357
10.1128/jvi.68.11.7131-7138.1994 / J. Virol. by Sif S. (1994)
10.1073/pnas.90.21.10193
10.1128/MCB.13.7.3964
10.1002/j.1460-2075.1993.tb06066.x
10.1038/326711a0
10.1016/0092-8674(86)90346-6
Del Prete G. F. DeCarli M. D'Elios M. M. Daniel K. C. Almerigogna F. Alderson M. Smith C. A. Thomas E.andRomagnani S. J. Exp. Med.1995: in press.
10.1016/1074-7613(95)90003-9

Dates

Type	When
Created	18 years, 5 months ago (March 1, 2007, 6:39 p.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 3:45 p.m.)
Indexed	2 months, 3 weeks ago (June 4, 2025, 5:47 a.m.)
Issued	29 years, 10 months ago (Oct. 1, 1995)
Published	29 years, 10 months ago (Oct. 1, 1995)
Published Online	19 years, 9 months ago (Nov. 23, 2005)
Published Print	29 years, 10 months ago (Oct. 1, 1995)

Funders 0

None

BibTeX

@article{McDonald_1995, title={CD30 ligation induces nuclear factor‐ϰB activation in human T cell lines}, volume={25}, ISSN={1521-4141}, url={http://dx.doi.org/10.1002/eji.1830251024}, DOI={10.1002/eji.1830251024}, number={10}, journal={European Journal of Immunology}, publisher={Wiley}, author={McDonald, Patrick P. and Cassatella, Marco A. and Bald, Anette and Maggi, Enrico and Romagnani, Sergio and Gruss, Hans‐Jürgen and Pizzolo, Giovanni}, year={1995}, month=oct, pages={2870–2876} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        4
      ]
    ],
    "date-time": "2025-06-04T09:47:32Z",
    "timestamp": 1749030452678
  },
  "reference-count": 31,
  "publisher": "Wiley",
  "issue": "10",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2005,
            11,
            23
          ]
        ],
        "date-time": "2005-11-23T00:00:00Z",
        "timestamp": 1132704000000
      },
      "content-version": "vor",
      "delay-in-days": 3706,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1995,
        10
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title><jats:p>CD30 is a recently described member of the tumor necrosis factor/nerve growth factor receptor superfamily. In this report, we show that following incubation of L540 cells (Hodgkin's disease\u2010derived, T cell\u2010like, CD30<jats:sup>+</jats:sup> cells) with the agonistic anti\u2010CD30 monoclonal antibodies (mAb) M44 and M67, two nuclear factor (NF)\u2010\u03f0B DNA binding activities were induced in nuclear extracts, as determined in gel retardation assays. The effect of the mAb towards NF\u2010\u03f0B activation was rapid, as it occurred within 20 min, and was sustained for up to 6h. By comparison, an isotype\u2010matched antibody had no effect on NF\u2010\u03f0B activation. Moreover, in human T helper (Th) clones functionally characterized as being of the type 0, type 1 and type 2 (28%, &lt; 1% und 93% CD30<jats:sup>+</jats:sup>, respectively), the extent of CD30\u2010mediated NF\u2010\u03f0B activation correlated with the proportion of CD30<jats:sup>+</jats:sup> cells. In all cell lines investigated, the NF\u2010\u03f0B complexes induced following CD30 engagement were shown to contain p50 NF\u2010\u03f0B1, p65 RelA, and possibly other transcription factors. Collectively, our results demonstrate that nuclear translocation and activation of NF\u2010\u03f0B rank among the short\u2010term cellular responses elicited following CD30 ligation.</jats:p>",
  "DOI": "10.1002/eji.1830251024",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2007,
        3,
        1
      ]
    ],
    "date-time": "2007-03-01T23:39:23Z",
    "timestamp": 1172792363000
  },
  "page": "2870-2876",
  "source": "Crossref",
  "is-referenced-by-count": 48,
  "title": "CD30 ligation induces nuclear factor\u2010\u03f0B activation in human T cell lines",
  "prefix": "10.1002",
  "volume": "25",
  "author": [
    {
      "given": "Patrick P.",
      "family": "McDonald",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Marco A.",
      "family": "Cassatella",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Anette",
      "family": "Bald",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Enrico",
      "family": "Maggi",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Sergio",
      "family": "Romagnani",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Hans\u2010J\u00fcrgen",
      "family": "Gruss",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Giovanni",
      "family": "Pizzolo",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2005,
        11,
        23
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/299065a0"
    },
    {
      "key": "e_1_2_1_3_2",
      "doi-asserted-by": "crossref",
      "first-page": "848",
      "DOI": "10.1182/blood.V66.4.848.848",
      "volume": "66",
      "author": "Stein H.",
      "year": "1985",
      "journal-title": "Blood"
    },
    {
      "key": "e_1_2_1_4_2",
      "doi-asserted-by": "crossref",
      "first-page": "1299",
      "DOI": "10.1182/blood.V63.6.1299.1299",
      "volume": "63",
      "author": "Andreesen R.",
      "year": "1984",
      "journal-title": "Blood"
    },
    {
      "key": "e_1_2_1_5_2",
      "doi-asserted-by": "crossref",
      "first-page": "2380",
      "DOI": "10.4049/jimmunol.151.5.2380",
      "volume": "151",
      "author": "Ellis T. M.",
      "year": "1993",
      "journal-title": "J. Immunol."
    },
    {
      "key": "e_1_2_1_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1096/fasebj.9.1.7821763"
    },
    {
      "key": "e_1_2_1_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1084/jem.180.6.2407"
    },
    {
      "key": "e_1_2_1_8_2",
      "doi-asserted-by": "crossref",
      "first-page": "2045",
      "DOI": "10.1182/blood.V83.8.2045.2045",
      "volume": "83",
      "author": "Gruss H.\u2010J.",
      "year": "1994",
      "journal-title": "Blood"
    },
    {
      "key": "e_1_2_1_9_2",
      "unstructured": "Gruss H.\u2010J. Hirschstein D. Alderson M. R.andArmitage R. J. J. Immunol.1995: in press."
    },
    {
      "key": "e_1_2_1_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90180-K"
    },
    {
      "key": "e_1_2_1_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(93)90361-S"
    },
    {
      "key": "e_1_2_1_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.iy.12.040194.001041"
    },
    {
      "key": "e_1_2_1_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.86.7.2336"
    },
    {
      "key": "e_1_2_1_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.86.15.5974"
    },
    {
      "key": "e_1_2_1_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.86.7.2365"
    },
    {
      "key": "e_1_2_1_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1993.tb06157.x"
    },
    {
      "key": "e_1_2_1_17_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90353-E"
    },
    {
      "key": "e_1_2_1_18_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00405072"
    },
    {
      "key": "e_1_2_1_19_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/11.5.1475"
    },
    {
      "key": "e_1_2_1_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(88)90382-0"
    },
    {
      "key": "e_1_2_1_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.72.7.2626"
    },
    {
      "key": "e_1_2_1_22_2",
      "doi-asserted-by": "crossref",
      "first-page": "2409",
      "DOI": "10.4049/jimmunol.146.7.2409",
      "volume": "146",
      "author": "H\u00e9mar A.",
      "year": "1991",
      "journal-title": "J. Immunol."
    },
    {
      "key": "e_1_2_1_23_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.82.20.6932"
    },
    {
      "key": "e_1_2_1_24_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.4049/jimmunol.153.10.4357"
    },
    {
      "key": "e_1_2_1_25_2",
      "doi-asserted-by": "crossref",
      "first-page": "7131",
      "DOI": "10.1128/jvi.68.11.7131-7138.1994",
      "volume": "68",
      "author": "Sif S.",
      "year": "1994",
      "journal-title": "J. Virol."
    },
    {
      "key": "e_1_2_1_26_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.90.21.10193"
    },
    {
      "key": "e_1_2_1_27_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.13.7.3964"
    },
    {
      "key": "e_1_2_1_28_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1993.tb06066.x"
    },
    {
      "key": "e_1_2_1_29_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/326711a0"
    },
    {
      "key": "e_1_2_1_30_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(86)90346-6"
    },
    {
      "key": "e_1_2_1_31_2",
      "unstructured": "Del Prete G. F. DeCarli M. D'Elios M. M. Daniel K. C. Almerigogna F. Alderson M. Smith C. A. Thomas E.andRomagnani S. J. Exp. Med.1995: in press."
    },
    {
      "key": "e_1_2_1_32_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/1074-7613(95)90003-9"
    }
  ],
  "container-title": "European Journal of Immunology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Feji.1830251024",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.1830251024",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        25
      ]
    ],
    "date-time": "2023-10-25T19:45:11Z",
    "timestamp": 1698263111000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1002/eji.1830251024"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1995,
        10
      ]
    ]
  },
  "references-count": 31,
  "journal-issue": {
    "issue": "10",
    "published-print": {
      "date-parts": [
        [
          1995,
          10
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1002/eji.1830251024"
  ],
  "URL": "http://dx.doi.org/10.1002/eji.1830251024",
  "relation": {},
  "ISSN": [
    "0014-2980",
    "1521-4141"
  ],
  "subject": [],
  "container-title-short": "Eur J Immunol",
  "published": {
    "date-parts": [
      [
        1995,
        10
      ]
    ]
  }
}