DOI: 10.1002/eji.1830251018. Altered CD40 ligand induction in tolerant T lymphocytes

Altered CD40 ligand induction in tolerant T lymphocytes

10.1002/eji.1830251018

Crossref journal-article

Wiley

European Journal of Immunology (311)

Abstract

AbstractCD40 ligand (CD40L) is a member of the tumor necrosis factor superfamily and is expressed on the surface of activated T lymphocytes. The interaction of CD40L with CD40 on B cells results in B cell activation, immunoglobulin (Ig) secretion and Ig class switching. To study anergy as a mechanism of murine CD4 T cell tolerance, we determined both in vivo and in vitro that CD3‐activated anergic cells are deficient in the ability to stimulate B cell proliferation, and that anergic cells are defective for the T cell receptor/CD3‐mediated induction of CD40L expression. These results have implications for the recruitment of B cell responses by anergic T cells in vivo.

Bibliography

Bowen, F., Haluskey, J., & Quill, H. (1995). Altered CD40 ligand induction in tolerant T lymphocytes. European Journal of Immunology, 25(10), 2830â2834. Portico.

Authors 3

Frank Bowen (first)
Joyce Haluskey (additional)
Helen Quill (additional)

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Dates

Type	When
Created	18 years, 6 months ago (March 1, 2007, 6:39 p.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 3:46 p.m.)
Indexed	5 months ago (March 31, 2025, 12:07 p.m.)
Issued	29 years, 11 months ago (Oct. 1, 1995)
Published	29 years, 11 months ago (Oct. 1, 1995)
Published Online	19 years, 9 months ago (Nov. 23, 2005)
Published Print	29 years, 11 months ago (Oct. 1, 1995)

Funders 0

None

BibTeX

@article{Bowen_1995, title={Altered CD40 ligand induction in tolerant T lymphocytes}, volume={25}, ISSN={1521-4141}, url={http://dx.doi.org/10.1002/eji.1830251018}, DOI={10.1002/eji.1830251018}, number={10}, journal={European Journal of Immunology}, publisher={Wiley}, author={Bowen, Frank and Haluskey, Joyce and Quill, Helen}, year={1995}, month=oct, pages={2830–2834} }

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