DOI: 10.1002/cne.901950302. The ontogeny of the distribution of callosal projection neurons in the rat parietal cortex

The ontogeny of the distribution of callosal projection neurons in the rat parietal cortex

10.1002/cne.901950302

Crossref journal-article

Wiley

Journal of Comparative Neurology (311)

Abstract

AbstractThe ontogeny of callosal projection neurons in the rat parietal cortex was examined using the retrograde and anterograde transport of horseradish peroxidase (HRP), as well as Golgi and Nissl stains. From postnatal day 0 (PND 0) to early PND 4, the callosal projection neurons are distributed as two continuous horizontal bands of cells which extend throughout the subplate in layers Va and Vc‐upper VIa. Neurons within the cortical plate (CP), however, do not transport HRP from a contralateral injection site until PND 3 to early PND 4, when a few cells at the lower CP border are generally labeled. However, by late on PND 4, and more consistently by PND 5, several changes in the distribution of callosal projection neurons take place. First, cells at all levels of the CP become labeled in a sequential fashion, from the lower border upward. Second, gaps, or areas devoid of HRP, become apparent in layer IV of the barrel field area. Third, in the cortical areas containing the gaps, as well as in other areas which are destined not to be callosally connected in the adult, there is a noticeable decrease in the number of cells labeled with HRP. This decrease continues through PND 15 and possibly into adulthood. The foregoing developmental events are compared to cortical maturation as seen in both Golgi‐ and Nissl‐stained material. By PND 15, the basic adult pattern of callosal projection neurons is established. The neurons reside mainly in layers III and Va, with fewer in layers II and Vc‐upper VIa, and fewer still in the other cortical layers. They are aligned in vertical arrays in discrete areas of the cortex.

Bibliography

Ivy, G. O., & Killackey, H. P. (1981). The ontogeny of the distribution of callosal projection neurons in the rat parietal cortex. Journal of Comparative Neurology, 195(3), 367â389. Portico.

Authors 2

Gwen O. Ivy (first)
Herbert P. Killackey (additional)

References 46 Referenced 255

Akers‐Ryugo R.(1978)Ontogeny of Neocortical Circuitry: Development of Callosal and Corticocortical Connections of the Rat Parietal Cortex. Doctoral dissertation University of California Irvine. (10.1002/cne.901810305)
10.1002/cne.901810305
10.1038/192766b0
{'key': 'e_1_2_1_5_1', 'first-page': '7', 'volume-title': 'Studies on the Development of Behavior and the Nervous System', 'author': 'Berry M.', 'year': '1974'} / Studies on the Development of Behavior and the Nervous System by Berry M. (1974)
{'key': 'e_1_2_1_6_1', 'first-page': '691', 'article-title': 'The migration of neuroblasts in the developing cerebral cortex', 'volume': '99', 'author': 'Berry M.', 'year': '1965', 'journal-title': 'J. Anat.'} / J. Anat. / The migration of neuroblasts in the developing cerebral cortex by Berry M. (1965)
10.1038/264705a0
10.1002/cne.901570302
10.1016/0014-4886(67)90093-3
10.1016/0006-8993(79)90658-9
10.1016/0006-8993(79)90490-6
10.1002/cne.901760205
10.1002/ar.1091600311
{'key': 'e_1_2_1_14_1', 'first-page': '150', 'article-title': 'The growth of embryonic neurites', 'volume': '87', 'author': 'Hughes A.', 'year': '1957', 'journal-title': 'J. Anat. (Lond).'} / J. Anat. (Lond). / The growth of embryonic neurites by Hughes A. (1957)
10.1038/280231a0
10.1016/0304-3940(77)90185-9
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{'key': 'e_1_2_1_18_1', 'first-page': '573', 'article-title': 'Developmental changes in the distribution of callosal projection neurons of the rat parietal cortex', 'volume': '196', 'author': 'Ivy G. O.', 'year': '1979', 'journal-title': 'Anat. Rec.'} / Anat. Rec. / Developmental changes in the distribution of callosal projection neurons of the rat parietal cortex by Ivy G. O. (1979)
10.1007/978-1-4757-4951-9
10.1016/0006-8993(74)90118-8
{'key': 'e_1_2_1_21_1', 'first-page': '167', 'article-title': 'A gradient of callosal fiber development in the parietal cortex of the rat', 'volume': '5', 'author': 'Killackey H. P.', 'year': '1979', 'journal-title': 'Neurosci. Abstracts'} / Neurosci. Abstracts / A gradient of callosal fiber development in the parietal cortex of the rat by Killackey H. P. (1979)
10.1002/cne.901830206
{'key': 'e_1_2_1_23_1', 'first-page': '395', 'article-title': 'A new interpretation of the laminar development of cerebral cortex: Synaptogenesis in different layers of neopallium in the human fetus', 'volume': '178', 'author': 'Kostovic I.', 'year': '1974', 'journal-title': 'Anat. Rec.'} / Anat. Rec. / A new interpretation of the laminar development of cerebral cortex: Synaptogenesis in different layers of neopallium in the human fetus by Kostovic I. (1974)
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10.1159/000123779
10.1016/0006-8993(74)90500-9
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{'key': 'e_1_2_1_28_1', 'first-page': '41', 'article-title': 'La corteza cerebral del raton', 'volume': '20', 'author': 'Lorente de Nó R.', 'year': '1922', 'journal-title': 'Trab. Inst. Cajal Invest. Biol.'} / Trab. Inst. Cajal Invest. Biol. / La corteza cerebral del raton by Lorente de Nó R. (1922)
10.1016/0006-8993(79)90274-9
10.1016/0006-8993(78)90445-6
10.1177/24.12.63512
{'key': 'e_1_2_1_32_1', 'first-page': '1', 'article-title': 'The ontogenesis of cortical circuitry: The spatial distribution of synapses in somesthetic cortex of newborn dog', 'volume': '42', 'author': 'Molliver M. E.', 'year': '1970', 'journal-title': 'Ergebn. Anat. Entwickl.‐Gesch.'} / Ergebn. Anat. Entwickl.‐Gesch. / The ontogenesis of cortical circuitry: The spatial distribution of synapses in somesthetic cortex of newborn dog by Molliver M. E. (1970)
10.1016/0006-8993(75)90007-4
10.1002/cne.901870104
Rice F. L.(1975) The Development of the Primary Soma tosensory Cortex in the Mouse: (1) A Nissl Study of the Ontogenesis of the Barrels and the Barrel Field (2) A Quantitative Autoradiographic Study of the Time of Origin and Pattern of Migration of Neuroblasts in Area SI. Doctoral Dissertation Johns Hopkins University Baltimore. University Microfilms Inc. Ann Arbor 337pp.
10.1002/cne.901710408
10.1002/cne.901730307
10.1002/cne.901790407
10.1002/cne.901290105
10.1159/000139646
10.1002/cne.901770203
10.1002/cne.901750405
10.1016/0306-4522(79)90157-X
10.1002/cne.901680302
10.1002/cne.901750202
10.1002/cne.901780202
10.1002/cne.901640206

Dates

Type	When
Created	20 years, 8 months ago (Jan. 1, 2005, 3:56 p.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 9:50 p.m.)
Indexed	3 days, 13 hours ago (Sept. 3, 2025, 6:20 a.m.)
Issued	44 years, 7 months ago (Jan. 20, 1981)
Published	44 years, 7 months ago (Jan. 20, 1981)
Published Online	20 years, 10 months ago (Oct. 9, 2004)
Published Print	44 years, 7 months ago (Jan. 20, 1981)

Funders 0

None

BibTeX

@article{Ivy_1981, title={The ontogeny of the distribution of callosal projection neurons in the rat parietal cortex}, volume={195}, ISSN={1096-9861}, url={http://dx.doi.org/10.1002/cne.901950302}, DOI={10.1002/cne.901950302}, number={3}, journal={Journal of Comparative Neurology}, publisher={Wiley}, author={Ivy, Gwen O. and Killackey, Herbert P.}, year={1981}, month=jan, pages={367–389} }

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