DOI: 10.1002/cne.901940308. Fine structure and synaptic connections of the common spiny neuron of the rat neostriatum: A study employing intracellular injection of horseradish peroxidase

Fine structure and synaptic connections of the common spiny neuron of the rat neostriatum: A study employing intracellular injection of horseradish peroxidase

10.1002/cne.901940308

Crossref journal-article

Wiley

Journal of Comparative Neurology (311)

Abstract

AbstractMedium‐sized spiny neurons of the rat neostriatum, identified by intracellular injection of horseradish peroxidase, were examined at both light and electron microscopic levels. These neurons were characterized by their heavy investment of dendritic spines, beginning about 20 μm from the soma and continuing to the tips of the dendrites. Their axons arose from the soma or from a large dendritic trunk very near the soma, and tapered rapidly to form a main axonal branch from which arose several smaller initial collaterals. These arborized extensively throughout an area of about the same size as, and highly overlapping with, the dendritic field of the cell, while the main axon could be followed for distances of up to 1 mm in the direction of the globus pallidus. Three major synaptic types were seen in contact with spiny neurons.Boutons containing small round synaptic vesicles formed synapses exclusively with spiny regions of the dendrites, and most of these were axo‐spinous. Small, very pleomorphic synaptic vesicles characterized a second bouton type of unknown origin, which made contacts with somata, initial segments, and dendrites, but not dendritic spines. Boutons containing large pleomorphic synaptic vesicles had the most widespread distribution, contacting all regions including dendritic spines. Spines receiving these contacts also were postsynaptic to boutons containing small round vesicles. Axon collaterals of spiny cells formed synapses with large pleomorphic vesicles and made synapses with somata, initial segments of axons, dendrites, and dendritic spines of striatal neurons, including other spiny cells.

Bibliography

Wilson, C. J., & Groves, P. M. (1980). Fine structure and synaptic connections of the common spiny neuron of the rat neostriatum: A study employing intracellular injection of horseradish peroxidase. Journal of Comparative Neurology, 194(3), 599â615. Portico.

Authors 2

Charles J. Wilson (first)
Philip M. Groves (additional)

References 37 Referenced 408

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{'key': 'e_1_2_1_10_1', 'first-page': '181', 'article-title': 'The spiny neurons in the primate striatum: A Golgi and electron microscopic study', 'volume': '13', 'author': 'Fox C. A.', 'year': '1971', 'journal-title': 'J. Hirnforsch.'} / J. Hirnforsch. / The spiny neurons in the primate striatum: A Golgi and electron microscopic study by Fox C. A. (1971)
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Dates

Type	When
Created	20 years, 7 months ago (Jan. 1, 2005, 3:56 p.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 10:58 p.m.)
Indexed	3 days, 4 hours ago (Aug. 19, 2025, 6:03 a.m.)
Issued	44 years, 8 months ago (Dec. 1, 1980)
Published	44 years, 8 months ago (Dec. 1, 1980)
Published Online	20 years, 10 months ago (Oct. 9, 2004)
Published Print	44 years, 8 months ago (Dec. 1, 1980)

Funders 0

None

BibTeX

@article{Wilson_1980, title={Fine structure and synaptic connections of the common spiny neuron of the rat neostriatum: A study employing intracellular injection of horseradish peroxidase}, volume={194}, ISSN={1096-9861}, url={http://dx.doi.org/10.1002/cne.901940308}, DOI={10.1002/cne.901940308}, number={3}, journal={Journal of Comparative Neurology}, publisher={Wiley}, author={Wilson, Charles J. and Groves, Philip M.}, year={1980}, month=dec, pages={599–615} }

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