DOI: 10.1002/cne.901820410. Proliferative and degenerative events in the early development of chick dorsal root ganglia. I. Normal development

Proliferative and degenerative events in the early development of chick dorsal root ganglia. I. Normal development

10.1002/cne.901820410

Crossref journal-article

Wiley

Journal of Comparative Neurology (311)

Abstract

AbstractDevelopment of the chick dorsal root ganglia was examined in 4.5‐ to 9.5‐day embryos. Tritiated thymidine (3H ‐ TdR) and autoradiography was used to analyze proliferative activity and the Feulgen procedure to analyze degenerative activity in ganglia 12–17. Proliferative activity was found to be elevated through 4.5 days of incubation when as many as 14% of the ganglionic cells become labelled following a one‐hour exposure to 3H‐ TdR. By 6.5 to 7.5 days proliferative activity decreased to 2–4% in the lateroventral (LV) regions and to approximately 1% in the mediodorsal (MD) regions of the ganglia. However there appears to be increased proliferative activity by the end of the experimental period at 9.5 days. Birthdate studies demonstrate that large‐scale neuronal production occurs between 4.5 and 6.5 days in LV regions and between 4.5 and 7.5 days in the MD regions. After those times ganglionic proliferative activity must be largely nonneuronal in nature. This nonneuronal proliferation is greater in LV than in MD regions and in brachial than in nonbrachial ganglia.Degenerative activity was found to be absent from the ganglia until after 4.5 days of incubation. It then increases rapidly, and by 5.5 days 5% of the LV cells in nonbrachial ganglia are degenerating. Degenerative activity then declines but is still present at 9.5 days. In contrast to results of an earlier study (Hamburger and Levi‐Montalcini, '49), degenerative activity was also found in the LV region of brachial ganglia and the MD regions of brachial and nonbrachial ganglia. The pattern of LV degenerative activity in brachial ganglia is similar to that in nonbrachial activity increases throughout the experimental period, and by 9.5 days as many as 4% of the MD cells are degenerating.

Bibliography

McMillan Carr, V., & Simpson, S. B. (1978). Proliferative and degenerative events in the early development of chick dorsal root ganglia. I. Normal development. Journal of Comparative Neurology, 182(4), 727â739. Portico.

Authors 2

Virginia McMillan Carr (first)
Sidney B. Simpson (additional)

References 29 Referenced 198

{'key': 'e_1_2_1_2_1', 'first-page': '54', 'article-title': 'Cell death in chick embryos as studied by electron microscopy', 'volume': '95', 'author': 'Bellairs R.', 'year': '1961', 'journal-title': 'J. Anat. (London)'} / J. Anat. (London) / Cell death in chick embryos as studied by electron microscopy by Bellairs R. (1961)
{'key': 'e_1_2_1_3_1', 'first-page': '143', 'article-title': 'Formation of crystalline ribosomal arrays in cultured chick embryo dorsal root ganglia', 'volume': '109', 'author': 'Birks R. I.', 'year': '1971', 'journal-title': 'J. Anat. (London)'} / J. Anat. (London) / Formation of crystalline ribosomal arrays in cultured chick embryo dorsal root ganglia by Birks R. I. (1971)
{'key': 'e_1_2_1_4_1', 'first-page': '749', 'article-title': 'Peripheral effects on early development of chick spinal ganglia', 'volume': '1', 'author': 'McMcarr V.', 'year': '1975', 'journal-title': 'Neuroscience Abstracts'} / Neuroscience Abstracts / Peripheral effects on early development of chick spinal ganglia by McMcarr V. (1975)
10.1002/cne.901820411 / J. Comp. Neur. / Proliferative and degenerative events in the early development of chick dorsal root ganglia. II. Responses to alteed peripheral fields by McMcarr V. (1978)
10.1002/cne.901770105
10.1177/16.5.371
10.1111/j.1469-185X.1951.tb00774.x / Biol. Rev. / Cell death in normal vertebrate ontogeny by Glücksmann A. (1951)
10.1002/jmor.1050880104
10.1002/jez.1401110308
{'key': 'e_1_2_1_11_1', 'first-page': '359', 'article-title': 'The development of dorsal root ganglia and ventral horns in the opossum. A quantitative study', 'volume': '30', 'author': 'Hughes A.', 'year': '1973', 'journal-title': 'J. Embryol. Exp. Morph.'} / J. Embryol. Exp. Morph. / The development of dorsal root ganglia and ventral horns in the opossum. A quantitative study by Hughes A. (1973)
{'key': 'e_1_2_1_12_1', 'first-page': '270', 'volume-title': 'Developmental Neurobiology', 'author': 'Jacobson M.', 'year': '1970'} / Developmental Neurobiology by Jacobson M. (1970)
10.1016/0006-8993(71)90054-0
{'key': 'e_1_2_1_14_1', 'first-page': '399', 'article-title': 'Development of rat dorsal root ganglion neurons', 'volume': '153', 'author': 'Lawson S. N.', 'year': '1974', 'journal-title': 'Studies of cell birthdays and changes in mean cell diameter. Cell. Tiss. Res.'} / Studies of cell birthdays and changes in mean cell diameter. Cell. Tiss. Res. / Development of rat dorsal root ganglion neurons by Lawson S. N. (1974)
{'key': 'e_1_2_1_15_1', 'first-page': '198', 'article-title': "Recherches quantitatives sur la marche du processus de différentiation des neurons dan les ganglions spinaux de l'embryon de poulet", 'volume': '54', 'author': 'Levi‐Montalcini R.', 'year': '1943', 'journal-title': 'Arch. Biol.'} / Arch. Biol. / Recherches quantitatives sur la marche du processus de différentiation des neurons dan les ganglions spinaux de l'embryon de poulet by Levi‐Montalcini R. (1943)
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10.1007/BF00339491 / Z. Zellforsch. / Number and structure of perisomatic satellite cells of spinal ganglia under normal conditions or during axon regeneration and neuronal hypertrophy by Pannese E. (1964)
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{'issue': '5', 'key': 'e_1_2_1_20_1', 'first-page': '1', 'article-title': 'The histogenesis of the spinal ganglia', 'volume': '47', 'author': 'Pannese E.', 'year': '1974', 'journal-title': 'Adv. Anat. Embryol. Cell Biol.'} / Adv. Anat. Embryol. Cell Biol. / The histogenesis of the spinal ganglia by Pannese E. (1974)
10.1002/cne.901600404
{'key': 'e_1_2_1_22_1', 'first-page': '63', 'article-title': 'Cell turnover in the spinal ganglia of\nXenopus laevis tadpoles', 'volume': '13', 'author': 'Prestige M. C.', 'year': '1965', 'journal-title': 'J. Embryol. Exp. Morph.'} / J. Embryol. Exp. Morph. / Cell turnover in the spinal ganglia of Xenopus laevis tadpoles by Prestige M. C. (1965)
10.1002/cne.901470302
10.1007/BF00406264
{'key': 'e_1_2_1_25_1', 'first-page': '28', 'volume-title': 'Physical Techniques in Biological Research', 'author': 'Schultze B.', 'year': '1969'} / Physical Techniques in Biological Research by Schultze B. (1969)
10.1002/jcp.1040910215
10.1007/978-3-642-85986-1_12 / Contemporary Research Methods. in Neuroanatomy by Sidman R. L. (1970)
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{'key': 'e_1_2_1_29_1', 'first-page': '279', 'article-title': 'A radiographic analysis of the migration and localization of trunk neural crest cells, in the chick', 'volume': '6', 'author': 'Weston J. A.', 'year': '1963', 'journal-title': 'Evel. Biol.'} / Evel. Biol. / A radiographic analysis of the migration and localization of trunk neural crest cells, in the chick by Weston J. A. (1963)
{'key': 'e_1_2_1_30_1', 'first-page': '167', 'article-title': 'A study of cell division in chick embryonic ganglion', 'volume': '147', 'author': 'Yates R. D.', 'year': '1961', 'journal-title': 'J. Exp. Neur.'} / J. Exp. Neur. / A study of cell division in chick embryonic ganglion by Yates R. D. (1961)

Dates

Type	When
Created	20 years, 8 months ago (Jan. 1, 2005, 1:29 p.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 10:35 p.m.)
Indexed	2 months, 1 week ago (June 25, 2025, 4:24 p.m.)
Issued	46 years, 8 months ago (Dec. 15, 1978)
Published	46 years, 8 months ago (Dec. 15, 1978)
Published Online	20 years, 10 months ago (Oct. 14, 2004)
Published Print	46 years, 8 months ago (Dec. 15, 1978)

Funders 0

None

BibTeX

@article{McMillan_Carr_1978, title={Proliferative and degenerative events in the early development of chick dorsal root ganglia. I. Normal development}, volume={182}, ISSN={1096-9861}, url={http://dx.doi.org/10.1002/cne.901820410}, DOI={10.1002/cne.901820410}, number={4}, journal={Journal of Comparative Neurology}, publisher={Wiley}, author={McMillan Carr, Virginia and Simpson, Sidney B.}, year={1978}, month=dec, pages={727–739} }

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