DOI: 10.1002/cne.901820106. Differential projections of cat medullary raphe neurons demonstrated by retrograde labelling following spinal cord lesions

Differential projections of cat medullary raphe neurons demonstrated by retrograde labelling following spinal cord lesions

10.1002/cne.901820106

Crossref journal-article

Wiley

Journal of Comparative Neurology (311)

Abstract

AbstractNeurons of the medullary raphe nuclei in cats were retrogradely labelled following injection of horseradish peroxidase (HRP) into the L6 spinal cord segment. Brainstems were cut in sagittal section to facilitate examination of the rostral‐caudal extend of raphe neurons projecting to the spinal cord. Large numbers of HRP‐labelled neurons were found in nucleus raphe magnus, nucleus raphe pallidus, and nucleus raphe obscurus (as well as a few neurons in nucleus raphe pontis). Dorsal or ventral hemisections at the T12‐L1 level restricted HRP retrograde transport to those pathways within the intact portion of spinal cord, allowing a determination of the part of the cord through which raphe neurons project to the lumbar enlargement. Neurons of nucleus raphe magus were found to project primarily in dorsolateral fasciculus. A significant number of neurons of nucleus reticularis gigantocellularis also project in dorsolateral fasciculus. Nucleus raphe obscurus neurons were found to project primarily in ventral funiculus, while nucleus raphe pallidus neurons project in the ventrolateral fasciculi and ventral funiculus. The serotonergic (5HT) fibers described by Dahlström and Fuxe ('65) to terminate in the dorsal horn, intermediolateral cell column, and ventral horn are likely to coincide with the raphe‐spinal projections documented in this work.

Bibliography

Martin, R. F., Jordan, L. M., & Willis, W. D. (1978). Differential projections of cat medullary raphe neurons demonstrated by retrograde labelling following spinal cord lesions. Journal of Comparative Neurology, 182(1), 77â88. Portico.

Authors 3

R. F. Martin (first)
L. M. Jordan (additional)
W. D. Willis (additional)

References 35 Referenced 152

10.1038/2021222a0
{'key': 'e_1_2_1_3_1', 'first-page': '511', 'volume-title': 'Advances in Pain Research', 'author': 'Basbaum A. I.', 'year': '1976'} / Advances in Pain Research by Basbaum A. I. (1976)
10.1016/0006-8993(76)90675-2
{'key': 'e_1_2_1_5_1', 'volume-title': 'The Brainstem of the Cat', 'author': 'Berman A. L.', 'year': '1968'} / The Brainstem of the Cat by Berman A. L. (1968)
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{'issue': '247', 'key': 'e_1_2_1_9_1', 'first-page': '37', 'article-title': 'Evidence of the existence of monoamine neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of neurons. IV. Distribution of monoamine nerve terminals in the nervous system', 'volume': '64', 'author': 'Dahlström A.', 'year': '1965', 'journal-title': 'Acta Physiol. Scand.'} / Acta Physiol. Scand. / Evidence of the existence of monoamine neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of neurons. IV. Distribution of monoamine nerve terminals in the nervous system by Dahlström A. (1965)
{'key': 'e_1_2_1_10_1', 'first-page': '293', 'article-title': 'An excitatory action of 5‐hydroxytryptamine on sympathetic preganglionic neurones', 'volume': '3', 'author': 'DeGroat W. C.', 'year': '1967', 'journal-title': 'Exp. Brain Res.'} / Exp. Brain Res. / An excitatory action of 5‐hydroxytryptamine on sympathetic preganglionic neurones by DeGroat W. C. (1967)
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Jordan L. M. D. R.Kenshalo Jr. R. F.Martin L. H.HaberandW. D.Willis(1978 submitted for publication) Two populations of spinothalamic tract neurons with opposite responses to 5‐hydroxytryptamine. (10.1016/0304-3959(78)90035-0)
Kenshalo D. R. Jr. R. F.Martin L. H.Haber W. D.WillisandW. D.Jordan1978Depression of primate spinothalamic tract neurons by iontophoretic application of 5‐hydroxytryptamine.Pain in press. (10.1016/0304-3959(78)90035-0)
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{'key': 'e_1_2_1_35_1', 'first-page': '420', 'article-title': 'Responses of spinal cord interneurons to acetylcholine, norepinehrine, and serotonin administered by microiontophoresis', 'volume': '153', 'author': 'Weight F. F.', 'year': '1966', 'journal-title': 'J. Pharm. Exp. Therap.'} / J. Pharm. Exp. Therap. / Responses of spinal cord interneurons to acetylcholine, norepinehrine, and serotonin administered by microiontophoresis by Weight F. F. (1966)
10.1152/jn.1977.40.4.968 / J. Neurophysiol. / Inhibition of spinothalamic tract cells and interneurons by brainstem stimulation in the monkey by Willis W. D. (1977)

Dates

Type	When
Created	20 years, 8 months ago (Jan. 1, 2005, 1:28 p.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 10:37 p.m.)
Indexed	1 day, 16 hours ago (Sept. 4, 2025, 9:52 a.m.)
Issued	46 years, 10 months ago (Nov. 1, 1978)
Published	46 years, 10 months ago (Nov. 1, 1978)
Published Online	20 years, 10 months ago (Oct. 9, 2004)
Published Print	46 years, 10 months ago (Nov. 1, 1978)

Funders 0

None

BibTeX

@article{Martin_1978, title={Differential projections of cat medullary raphe neurons demonstrated by retrograde labelling following spinal cord lesions}, volume={182}, ISSN={1096-9861}, url={http://dx.doi.org/10.1002/cne.901820106}, DOI={10.1002/cne.901820106}, number={1}, journal={Journal of Comparative Neurology}, publisher={Wiley}, author={Martin, R. F. and Jordan, L. M. and Willis, W. D.}, year={1978}, month=nov, pages={77–88} }

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