DOI: 10.1002/cne.901320110. Chromatolysis in the hypoglossal nucleus of the rat: An electron microscopic analysis

Chromatolysis in the hypoglossal nucleus of the rat: An electron microscopic analysis

10.1002/cne.901320110

Crossref journal-article

Wiley

Journal of Comparative Neurology (311)

Abstract

AbstractChromatolysis was induced by cutting the hypoglossal nerve in young rats and the hypoglossal nucleus was examined by light and electron microscopy. Mitochondria in chromatolytic and control neurons, compared quantitatively, showed no change through the sixth day. A decrease in the mitochondria to cytoplasm ratio was present at the tenth day. The glial cells of the nucleus showed a hyperplastic reaction during early stages. Loosening of contact between neurons and glia as well as complex invagination of neurons by glial processes was observed. Other findings included a prominent juxtanuclear Nissl mass in chromatolyic neurons and degenerating neurites in both ipsi‐ and contralateral nuclei.

Bibliography

Kirkpatrick, J. B. (1968). Chromatolysis in the hypoglossal nucleus of the rat: An electron microscopic analysis. Journal of Comparative Neurology, 132(1), 189â211. Portico.

Authors 1

Joel B. Kirkpatrick (first)

References 49 Referenced 72

10.1002/cne.900890203
10.1007/BF00686608
{'key': 'e_1_2_1_4_1', 'first-page': '13', 'article-title': 'An electron‐microscopic study of the monkey spinal cord', 'volume': '114', 'author': 'Bodian D.', 'year': '1964', 'journal-title': 'Bull. Johns Hopkins Hosp.'} / Bull. Johns Hopkins Hosp. / An electron‐microscopic study of the monkey spinal cord by Bodian D. (1964)
10.1111/j.1471-4159.1957.tb12088.x
10.1002/cne.901020107
10.1097/00005072-196310000-00003
{'key': 'e_1_2_1_8_1', 'first-page': '195', 'article-title': 'Histiocytes, juxtavascular mitotic cells and microglia cells during retrograde changes in the facial nucleus of rabbits of varying age', 'volume': '38', 'author': 'Cammermeyer J.', 'year': '1965', 'journal-title': 'Ergebn. Anat. Entwicklungsgesch.'} / Ergebn. Anat. Entwicklungsgesch. / Histiocytes, juxtavascular mitotic cells and microglia cells during retrograde changes in the facial nucleus of rabbits of varying age by Cammermeyer J. (1965)
{'key': 'e_1_2_1_9_1', 'first-page': '281', 'article-title': 'A chrome‐osmium fixative for electron microscopy', 'volume': '121', 'author': 'Dalton A. J.', 'year': '1955', 'journal-title': 'Anat. Rec.'} / Anat. Rec. / A chrome‐osmium fixative for electron microscopy by Dalton A. J. (1955)
10.1016/0006-3002(53)90155-3
10.1136/jnnp.18.1.1
10.1097/00005072-196507000-00012
10.1016/0014-4886(59)90043-3
10.1001/archneurpsyc.1933.02240070094005
10.1073/pnas.41.11.874
10.1007/BF02138497
10.1152/jn.1963.26.6.835 / J. Neurophysiol. / Membrane potentials in hypoglossal motoneurons by Green J. D. (1963)
10.1111/j.1748-1716.1966.tb03289.x
{'issue': '237', 'key': 'e_1_2_1_19_1', 'first-page': '1', 'article-title': 'Carboxylic esterases, oxidative enzymes, and catecholamines in the superior cervical ganglion of the rat and the effect of pre‐ and postganglionic nerve division', 'volume': '63', 'author': 'Härkönen M.', 'year': '1964', 'journal-title': 'Acta Physiol. Scand.'} / Acta Physiol. Scand. / Carboxylic esterases, oxidative enzymes, and catecholamines in the superior cervical ganglion of the rat and the effect of pre‐ and postganglionic nerve division by Härkönen M. (1964)
10.1002/ar.1091000105 / Anat. Rec. / Mitochondria in nerve cell bodies following section of axones by Hartman J. F. (1948)
10.1002/ar.1091180103 / Anat. Rec. / Electron microscopy of motor nerve cells following section of axones by Hartman J. F. (1954)
10.1083/jcb.33.2.419
10.1016/0014-4827(61)90445-1
10.1111/j.1471-4159.1960.tb13449.x
10.1016/S0022-5320(66)80001-1
{'key': 'e_1_2_1_26_1', 'first-page': '137A', 'article-title': 'A formaldehyde‐glutaraldehyde fixative of high osmolality for use in electron microscopy', 'volume': '27', 'author': 'Karnofsky M. J.', 'year': '1965', 'journal-title': 'J. Cell Biol.'} / J. Cell Biol. / A formaldehyde‐glutaraldehyde fixative of high osmolality for use in electron microscopy by Karnofsky M. J. (1965)
10.1159/000142473
10.1212/WNL.17.4.349
10.1002/ar.1091500204
10.1083/jcb.15.3.481
10.1097/00005072-196407000-00008
10.1111/j.1471-4159.1961.tb13500.x
10.1016/0014-4827(53)90197-9
10.1007/BF00334866
{'key': 'e_1_2_1_35_1', 'first-page': '197', 'article-title': 'Uber die Veränderungen der Ganglienzellen am Facialiskern des Kannichens nach Ausreissung der Nerven', 'volume': '48', 'author': 'Nissl F.', 'year': '1892', 'journal-title': 'Allg. Z. Psychiat.'} / Allg. Z. Psychiat. / Uber die Veränderungen der Ganglienzellen am Facialiskern des Kannichens nach Ausreissung der Nerven by Nissl F. (1892)
10.1007/BF00343854
10.1007/BF00344001
Ramón y Cajal S.1909Histologie du Systèm Nerveux de l'Homme et des Vertébrés. Vol.1 p.707 Fig. 291. Reprinted by Instituto Ramón y Cajal Madrid 1952. (10.5962/bhl.title.48637)
{'key': 'e_1_2_1_39_1', 'first-page': '211', 'article-title': 'Veränderungen der Neuroglia im Nucleus origin nervi hypoglossi nach mechanischer Beschädigung des Nervus hypoglossus', 'volume': '65', 'author': 'Rapoš M.', 'year': '1959', 'journal-title': 'Z. Mikr. Anat. Forsch.'} / Z. Mikr. Anat. Forsch. / Veränderungen der Neuroglia im Nucleus origin nervi hypoglossi nach mechanischer Beschädigung des Nervus hypoglossus by Rapoš M. (1959)
10.1083/jcb.22.2.365 / J. Cell Biol. / Wound healing and collagen formation. IV. Distortion of ribosomal patterns of fibroblasts in scurvy by Ross R. (1963)
10.1007/BF00347712
{'key': 'e_1_2_1_42_1', 'first-page': '67', 'article-title': 'Studies on glial cells in the hypoglossal nucleus of the rabbit during nerve regeneration and morphological changes in glial cells during nerve regeneration', 'volume': '270', 'author': 'Sjöstrand J.', 'year': '1966', 'journal-title': 'Acta Physiol. Scand.'} / Acta Physiol. Scand. / Studies on glial cells in the hypoglossal nucleus of the rabbit during nerve regeneration and morphological changes in glial cells during nerve regeneration by Sjöstrand J. (1966)
10.1002/cne.901160202
10.2535/ofaj1936.40.1_1
10.1113/jphysiol.1965.sp007728
10.1111/j.1471-4159.1966.tb09869.x / J. Neurochem. / Alteration of the adherence of glia to neurons following nerve injury by Watson W. E. (1966)
10.1083/jcb.12.2.361
10.1083/jcb.30.1.23
10.1002/jez.1401070302
10.1073/pnas.54.1.48

Dates

Type	When
Created	20 years, 8 months ago (Jan. 1, 2005, 6:22 p.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 6:54 p.m.)
Indexed	2 days, 9 hours ago (Sept. 4, 2025, 9:36 a.m.)
Issued	57 years, 8 months ago (Jan. 1, 1968)
Published	57 years, 8 months ago (Jan. 1, 1968)
Published Online	20 years, 10 months ago (Oct. 8, 2004)
Published Print	57 years, 8 months ago (Jan. 1, 1968)

Funders 0

None

BibTeX

@article{Kirkpatrick_1968, title={Chromatolysis in the hypoglossal nucleus of the rat: An electron microscopic analysis}, volume={132}, ISSN={1096-9861}, url={http://dx.doi.org/10.1002/cne.901320110}, DOI={10.1002/cne.901320110}, number={1}, journal={Journal of Comparative Neurology}, publisher={Wiley}, author={Kirkpatrick, Joel B.}, year={1968}, month=jan, pages={189–211} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        4
      ]
    ],
    "date-time": "2025-09-04T13:36:07Z",
    "timestamp": 1756992967327
  },
  "reference-count": 49,
  "publisher": "Wiley",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2004,
            10,
            8
          ]
        ],
        "date-time": "2004-10-08T00:00:00Z",
        "timestamp": 1097193600000
      },
      "content-version": "vor",
      "delay-in-days": 13430,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1968,
        1
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title><jats:p>Chromatolysis was induced by cutting the hypoglossal nerve in young rats and the hypoglossal nucleus was examined by light and electron microscopy. Mitochondria in chromatolytic and control neurons, compared quantitatively, showed no change through the sixth day. A decrease in the mitochondria to cytoplasm ratio was present at the tenth day. The glial cells of the nucleus showed a hyperplastic reaction during early stages. Loosening of contact between neurons and glia as well as complex invagination of neurons by glial processes was observed. Other findings included a prominent juxtanuclear Nissl mass in chromatolyic neurons and degenerating neurites in both ipsi\u2010 and contralateral nuclei.</jats:p>",
  "DOI": "10.1002/cne.901320110",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2005,
        1,
        1
      ]
    ],
    "date-time": "2005-01-01T23:22:50Z",
    "timestamp": 1104621770000
  },
  "page": "189-211",
  "source": "Crossref",
  "is-referenced-by-count": 72,
  "title": "Chromatolysis in the hypoglossal nucleus of the rat: An electron microscopic analysis",
  "prefix": "10.1002",
  "volume": "132",
  "author": [
    {
      "given": "Joel B.",
      "family": "Kirkpatrick",
      "sequence": "first",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2004,
        10,
        8
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_2_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/cne.900890203"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00686608"
    },
    {
      "key": "e_1_2_1_4_1",
      "first-page": "13",
      "article-title": "An electron\u2010microscopic study of the monkey spinal cord",
      "volume": "114",
      "author": "Bodian D.",
      "year": "1964",
      "journal-title": "Bull. Johns Hopkins Hosp."
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1471-4159.1957.tb12088.x"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/cne.901020107"
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00005072-196310000-00003"
    },
    {
      "key": "e_1_2_1_8_1",
      "first-page": "195",
      "article-title": "Histiocytes, juxtavascular mitotic cells and microglia cells during retrograde changes in the facial nucleus of rabbits of varying age",
      "volume": "38",
      "author": "Cammermeyer J.",
      "year": "1965",
      "journal-title": "Ergebn. Anat. Entwicklungsgesch."
    },
    {
      "key": "e_1_2_1_9_1",
      "first-page": "281",
      "article-title": "A chrome\u2010osmium fixative for electron microscopy",
      "volume": "121",
      "author": "Dalton A. J.",
      "year": "1955",
      "journal-title": "Anat. Rec."
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0006-3002(53)90155-3"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/jnnp.18.1.1"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00005072-196507000-00012"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-4886(59)90043-3"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1001/archneurpsyc.1933.02240070094005"
    },
    {
      "key": "e_1_2_1_15_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.41.11.874"
    },
    {
      "key": "e_1_2_1_16_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF02138497"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "crossref",
      "first-page": "835",
      "DOI": "10.1152/jn.1963.26.6.835",
      "article-title": "Membrane potentials in hypoglossal motoneurons",
      "volume": "26",
      "author": "Green J. D.",
      "year": "1963",
      "journal-title": "J. Neurophysiol."
    },
    {
      "key": "e_1_2_1_18_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1748-1716.1966.tb03289.x"
    },
    {
      "issue": "237",
      "key": "e_1_2_1_19_1",
      "first-page": "1",
      "article-title": "Carboxylic esterases, oxidative enzymes, and catecholamines in the superior cervical ganglion of the rat and the effect of pre\u2010 and postganglionic nerve division",
      "volume": "63",
      "author": "H\u00e4rk\u00f6nen M.",
      "year": "1964",
      "journal-title": "Acta Physiol. Scand."
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "crossref",
      "first-page": "49",
      "DOI": "10.1002/ar.1091000105",
      "article-title": "Mitochondria in nerve cell bodies following section of axones",
      "volume": "100",
      "author": "Hartman J. F.",
      "year": "1948",
      "journal-title": "Anat. Rec."
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "crossref",
      "first-page": "19",
      "DOI": "10.1002/ar.1091180103",
      "article-title": "Electron microscopy of motor nerve cells following section of axones",
      "volume": "118",
      "author": "Hartman J. F.",
      "year": "1954",
      "journal-title": "Anat. Rec."
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.33.2.419"
    },
    {
      "key": "e_1_2_1_23_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-4827(61)90445-1"
    },
    {
      "key": "e_1_2_1_24_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1471-4159.1960.tb13449.x"
    },
    {
      "key": "e_1_2_1_25_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0022-5320(66)80001-1"
    },
    {
      "key": "e_1_2_1_26_1",
      "first-page": "137A",
      "article-title": "A formaldehyde\u2010glutaraldehyde fixative of high osmolality for use in electron microscopy",
      "volume": "27",
      "author": "Karnofsky M. J.",
      "year": "1965",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "e_1_2_1_27_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1159/000142473"
    },
    {
      "key": "e_1_2_1_28_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1212/WNL.17.4.349"
    },
    {
      "key": "e_1_2_1_29_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/ar.1091500204"
    },
    {
      "key": "e_1_2_1_30_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.15.3.481"
    },
    {
      "key": "e_1_2_1_31_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00005072-196407000-00008"
    },
    {
      "key": "e_1_2_1_32_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1471-4159.1961.tb13500.x"
    },
    {
      "key": "e_1_2_1_33_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-4827(53)90197-9"
    },
    {
      "key": "e_1_2_1_34_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00334866"
    },
    {
      "key": "e_1_2_1_35_1",
      "first-page": "197",
      "article-title": "Uber die Ver\u00e4nderungen der Ganglienzellen am Facialiskern des Kannichens nach Ausreissung der Nerven",
      "volume": "48",
      "author": "Nissl F.",
      "year": "1892",
      "journal-title": "Allg. Z. Psychiat."
    },
    {
      "key": "e_1_2_1_36_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00343854"
    },
    {
      "key": "e_1_2_1_37_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00344001"
    },
    {
      "key": "e_1_2_1_38_1",
      "doi-asserted-by": "crossref",
      "unstructured": "Ram\u00f3n y Cajal S.1909Histologie du Syst\u00e8m Nerveux de l'Homme et des Vert\u00e9br\u00e9s. Vol.1 p.707 Fig. 291. Reprinted by Instituto Ram\u00f3n y Cajal Madrid 1952.",
      "DOI": "10.5962/bhl.title.48637"
    },
    {
      "key": "e_1_2_1_39_1",
      "first-page": "211",
      "article-title": "Ver\u00e4nderungen der Neuroglia im Nucleus origin nervi hypoglossi nach mechanischer Besch\u00e4digung des Nervus hypoglossus",
      "volume": "65",
      "author": "Rapo\u0161 M.",
      "year": "1959",
      "journal-title": "Z. Mikr. Anat. Forsch."
    },
    {
      "key": "e_1_2_1_40_1",
      "doi-asserted-by": "crossref",
      "first-page": "365",
      "DOI": "10.1083/jcb.22.2.365",
      "article-title": "Wound healing and collagen formation. IV. Distortion of ribosomal patterns of fibroblasts in scurvy",
      "volume": "22",
      "author": "Ross R.",
      "year": "1963",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "e_1_2_1_41_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00347712"
    },
    {
      "key": "e_1_2_1_42_1",
      "first-page": "67",
      "article-title": "Studies on glial cells in the hypoglossal nucleus of the rabbit during nerve regeneration and morphological changes in glial cells during nerve regeneration",
      "volume": "270",
      "author": "Sj\u00f6strand J.",
      "year": "1966",
      "journal-title": "Acta Physiol. Scand."
    },
    {
      "key": "e_1_2_1_43_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/cne.901160202"
    },
    {
      "key": "e_1_2_1_44_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.2535/ofaj1936.40.1_1"
    },
    {
      "key": "e_1_2_1_45_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1113/jphysiol.1965.sp007728"
    },
    {
      "key": "e_1_2_1_46_1",
      "doi-asserted-by": "crossref",
      "first-page": "536",
      "DOI": "10.1111/j.1471-4159.1966.tb09869.x",
      "article-title": "Alteration of the adherence of glia to neurons following nerve injury",
      "volume": "13",
      "author": "Watson W. E.",
      "year": "1966",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "e_1_2_1_47_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.12.2.361"
    },
    {
      "key": "e_1_2_1_48_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.30.1.23"
    },
    {
      "key": "e_1_2_1_49_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jez.1401070302"
    },
    {
      "key": "e_1_2_1_50_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.54.1.48"
    }
  ],
  "container-title": "Journal of Comparative Neurology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcne.901320110",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/cne.901320110",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        11,
        12
      ]
    ],
    "date-time": "2023-11-12T23:54:21Z",
    "timestamp": 1699833261000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1002/cne.901320110"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1968,
        1
      ]
    ]
  },
  "references-count": 49,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1968,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1002/cne.901320110"
  ],
  "URL": "http://dx.doi.org/10.1002/cne.901320110",
  "relation": {},
  "ISSN": [
    "0021-9967",
    "1096-9861"
  ],
  "subject": [],
  "container-title-short": "J of Comparative Neurology",
  "published": {
    "date-parts": [
      [
        1968,
        1
      ]
    ]
  }
}