DOI: 10.1002/cm.970130307. What structures, besides adhesions, prevent spread cells from rounding up?

What structures, besides adhesions, prevent spread cells from rounding up?

10.1002/cm.970130307

Crossref journal-article

Wiley

Cell Motility (311)

Abstract

AbstractThe outline of cells in sparse cultures consists prediminantly of concave and convex segments; straight segments are rare and ephemeral. The convex segments are areas of active cell expansion. The concave segments are stationary and web‐shaped, similar in profile to the cables of a suspension bridge. In 3T3 fibroblasts, we have found a single microfilament bundle following the outline of every webbed edge and have called it the actin edge‐bundle (AEB). While the AEB is composed predominantly of actin, α‐actinin and myosin are also present. In contrast to normal stress fibers, AEBs are more resistant to several treatments that depolymerize F‐actin. Once an AEB disassembles, however, the webbed edge collapses and retracts, suggesting that the actin edge‐bundle is a specialized cytoskeletal structure that supports the webbed edges of interphase 3T3 fibroblasts. The stability of AEBs is independent of microtubules. We suggest that the microfilament bundles that frequently line the lateral contacts between epithelial cells in vivo may be related to the actin edge‐bundle.

Bibliography

Zand, M. S., & AlbrechtâBuehler, G. (1989). What structures, besides adhesions, prevent spread cells from rounding up? Cell Motility, 13(3), 195â211. Portico.

Authors 2

Martin S. Zand (first)
Guenter Albrecht‐Buehler (additional)

References 34 Referenced 41

10.1016/0014-4827(70)90646-4
{'key': 'e_1_2_1_3_1', 'first-page': '87', 'volume-title': 'The Transformed Phenotype', 'author': 'Albrecht‐Buehler G.', 'year': '1984'} / The Transformed Phenotype by Albrecht‐Buehler G. (1984)
10.1002/cm.970070108
10.1016/0014-4827(79)90542-1
10.1016/0092-8674(80)90473-0
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10.1002/cm.970110403
10.1038/273345a0
{'key': 'e_1_2_1_12_1', 'first-page': '227', 'article-title': 'Cytoplasmic contractile apparatus in aortic endothelial cells', 'volume': '32', 'author': 'Gabbiani G.', 'year': '1975', 'journal-title': 'Lab. Invest.'} / Lab. Invest. / Cytoplasmic contractile apparatus in aortic endothelial cells by Gabbiani G. (1975)
10.1073/pnas.80.8.2361
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10.1002/cm.970080204
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{'key': 'e_1_2_1_20_1', 'volume-title': 'Tissues and Organs. A Text Atlas of Scanning Electron Microscopy', 'author': 'Kessel R. G.', 'year': '1979'} / Tissues and Organs. A Text Atlas of Scanning Electron Microscopy by Kessel R. G. (1979)
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10.1002/ar.1090060502
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10.1083/jcb.106.3.747
10.1016/0165-3806(89)90007-2
10.1242/jcs.82.1.235 / J. Cell Sci. / Actin cytoskeleton of spread fibroblasts appears to assemble at the cell edges by Svitkina T. M. (1986)
{'key': 'e_1_2_1_30_1', 'first-page': '279', 'volume-title': 'Cell Motility', 'author': 'Vasiliev J. M.', 'year': '1976'} / Cell Motility by Vasiliev J. M. (1976)
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10.1083/jcb.99.3.894
10.1002/cm.970130204

Dates

Type	When
Created	20 years, 6 months ago (Feb. 23, 2005, 10:36 p.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 7:46 a.m.)
Indexed	3 weeks ago (Aug. 12, 2025, 5:54 p.m.)
Issued	36 years, 8 months ago (Jan. 1, 1989)
Published	36 years, 8 months ago (Jan. 1, 1989)
Published Online	20 years, 6 months ago (Feb. 4, 2005)
Published Print	36 years, 8 months ago (Jan. 1, 1989)

Funders 0

None

BibTeX

@article{Zand_1989, title={What structures, besides adhesions, prevent spread cells from rounding up?}, volume={13}, ISSN={0886-1544}, url={http://dx.doi.org/10.1002/cm.970130307}, DOI={10.1002/cm.970130307}, number={3}, journal={Cell Motility}, publisher={Wiley}, author={Zand, Martin S. and Albrecht‐Buehler, Guenter}, year={1989}, month=jan, pages={195–211} }

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