DOI: 10.1002/cm.970030509. Talin: A cytoskeletal component concentrated in adhesion plaques and other sites of actin‐membrane interaction

Talin: A cytoskeletal component concentrated in adhesion plaques and other sites of actin‐membrane interaction

10.1002/cm.970030509

Crossref journal-article

Wiley

Cell Motility (311)

Abstract

AbstractTalin is a recently identified cytoskeletal protein with a polypeptide molecular weight of 215,000 daltons. In cultured fibroblasts talin has been localized by immunofluorescence in adhesion plaques (focal contacts), in the ruffling membranes and leading lamellae of the cell periphery, and in fibrillar patterns that align with microfilament bundles and/or with cell surface fibronectin. These cellular locations suggest that the protein could function either in the attachment of microfilaments to the plasma membane or in the organization of microfilaments close to membrane attachment sites. Cell transformation by viruses such as Rous sarcoma virus disrupts the normal organization of talin, and in most transformed cells talin appears distributed diffusely through the cytoplasm. In a few cells talin is detected in doughnut‐shaped aggregates, as a ring surrounding a central core of actin. The significance of these structures is uncertain, but in some cells the individual structures will condense to form much larger aggregates with a striking appearance when viewed by immunofluoresence microscopy.

Bibliography

Burridge, K., & Connell, L. (1983). Talin: A cytoskeletal component concentrated in adhesion plaques and other sites of actinâmembrane interaction. Cell Motility, 3(5), 405â417. Portico.

Authors 2

Keith Burridge (first)
Laurie Connell (additional)

References 24 Referenced 119

10.1073/pnas.77.2.980
10.1016/S0021-9258(17)40522-9 / J. Biol. Chem. / Selective association of spectrin with the cytoplasmic surface of human erythrocyte plasma membranes by Bennett V. (1977)
10.1016/0092-8674(81)90497-9
10.1073/pnas.78.11.6849
10.1083/jcb.86.1.335
10.1083/jcb.97.2.359
10.1016/S0092-8674(80)80035-3
10.1038/294565a0
10.1101/SQB.1982.046.01.055
10.1083/jcb.95.2.478
10.1083/jcb.90.3.797
10.1073/pnas.77.11.6687
10.1016/0092-8674(79)90368-4
10.1073/pnas.77.7.4127
10.1016/S0021-9258(19)52543-1 / J. Biol. Chem / F‐actin binding and bundling properties of fimbrin, a major cytoskeletal protein of microvillus core filaments by Glenny J. R. (1981)
10.1111/j.1749-6632.1978.tb16822.x
10.1016/0092-8674(78)90272-6
10.1073/pnas.78.5.3005
10.1038/227680a0
10.1016/0092-8674(75)90180-4
10.1083/jcb.83.3.667
10.1016/0092-8674(81)90512-2
10.1016/0092-8674(79)90040-0
10.1083/jcb.91.3.695

Dates

Type	When
Created	20 years, 4 months ago (April 11, 2005, 3:33 p.m.)
Deposited	1 year, 10 months ago (Oct. 19, 2023, 6:14 p.m.)
Indexed	2 days, 4 hours ago (Sept. 4, 2025, 10:23 a.m.)
Issued	42 years, 8 months ago (Jan. 1, 1983)
Published	42 years, 8 months ago (Jan. 1, 1983)
Published Online	20 years, 7 months ago (Feb. 4, 2005)
Published Print	42 years, 8 months ago (Jan. 1, 1983)

Funders 0

None

BibTeX

@article{Burridge_1983, title={Talin: A cytoskeletal component concentrated in adhesion plaques and other sites of actin‐membrane interaction}, volume={3}, ISSN={0271-6585}, url={http://dx.doi.org/10.1002/cm.970030509}, DOI={10.1002/cm.970030509}, number={5}, journal={Cell Motility}, publisher={Wiley}, author={Burridge, Keith and Connell, Laurie}, year={1983}, month=jan, pages={405–417} }

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