DOI: 10.1002/chem.201103605. Total Synthesis of Exiguamines A and B Inspired by Catecholamine Chemistry

Total Synthesis of Exiguamines A and B Inspired by Catecholamine Chemistry

10.1002/chem.201103605

Crossref journal-article

Wiley

Chemistry – A European Journal (311)

Abstract

AbstractThe evolution of a total synthesis of the exiguamines, two structurally unusual natural products that are highly active inhibitors of indolamine‐2,3‐dioxygenase (IDO), is described. The ultimately successful strategy involves advanced cross‐coupling methodology and features a potentially biosynthetic tautomerization/electrocyclization cascade reaction that forms two heterocycles and installs a quaternary ammonium ion in a single synthetic operation.

Bibliography

Sofiyev, V., Lumb, J., Volgraf, M., & Trauner, D. (2012). Total Synthesis of Exiguamines A and B Inspired by Catecholamine Chemistry. Chemistry â A European Journal, 18(16), 4999â5005. Portico.

Authors 4

Vladimir Sofiyev (first)
Jean‐Philip Lumb (additional)
Matthew Volgraf (additional)
Dirk Trauner (additional)

References 48 Referenced 35

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Jaguar version 6.5 Schrödinger LLC New York NY 2006.

Dates

Type	When
Created	13 years, 5 months ago (March 13, 2012, 11:46 a.m.)
Deposited	1 year, 11 months ago (Aug. 30, 2023, 2:47 p.m.)
Indexed	5 days, 12 hours ago (Aug. 23, 2025, 1:07 a.m.)
Issued	13 years, 5 months ago (March 13, 2012)
Published	13 years, 5 months ago (March 13, 2012)
Published Online	13 years, 5 months ago (March 13, 2012)
Published Print	13 years, 4 months ago (April 16, 2012)

Funders 0

None

BibTeX

@article{Sofiyev_2012, title={Total Synthesis of Exiguamines A and B Inspired by Catecholamine Chemistry}, volume={18}, ISSN={1521-3765}, url={http://dx.doi.org/10.1002/chem.201103605}, DOI={10.1002/chem.201103605}, number={16}, journal={Chemistry – A European Journal}, publisher={Wiley}, author={Sofiyev, Vladimir and Lumb, Jean‐Philip and Volgraf, Matthew and Trauner, Dirk}, year={2012}, month=mar, pages={4999–5005} }

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