DOI: 10.1002/chem.201002345. Synthesis and Application of Isocyanates Radiolabeled with Carbon‐11

Synthesis and Application of Isocyanates Radiolabeled with Carbon‐11

10.1002/chem.201002345

Crossref journal-article

Wiley

Chemistry – A European Journal (311)

Abstract

AbstractCarbon‐11 labeled isocyanates are efficiently prepared by dehydration of [11C]carbamate salts, which in turn are easily formed from cyclotron‐produced [11C]CO2 and amines in the presence of a CO2 fixation agent. The [11C]isocyanates are useful radiosynthons for the synthesis of a variety of [carbonyl‐11C]‐labeled asymmetrical ureas and carbamate esters. The method is well suited to incorporate any isotope of carbon, and is especially useful for positron emission tomography (PET) radiotracers for in vivo imaging. This is demonstrated by using the method to make [carbonyl‐11C]‐6‐hydroxy‐[1,1′‐biphenyl]‐3‐yl cyclohexylcarbamate which is a novel radiotracer for PET imaging of fatty acid amide hydrolase.

Bibliography

Wilson, A. A., Garcia, A., Houle, S., Sadovski, O., & Vasdev, N. (2010). Synthesis and Application of Isocyanates Radiolabeled with Carbonâ11. Chemistry â A European Journal, 17(1), 259â264. Portico.

Authors 5

Alan A. Wilson (first)
Armando Garcia (additional)
Sylvain Houle (additional)
Oleg Sadovski (additional)
Neil Vasdev (additional)

References 36 Referenced 76

{'key': 'e_1_2_6_1_2', 'volume-title': 'Principles and Practice of PET and PET/CT', 'author': 'Wahl R. L.', 'year': '2009'} / Principles and Practice of PET and PET/CT by Wahl R. L. (2009)
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A. A. Wilson A. Garcia J. Parkes S. Houle J. Tong S. Houle Nucl. Med. Biol.2010 DOI:.
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Dates

Type	When
Created	14 years, 9 months ago (Nov. 12, 2010, 9:30 a.m.)
Deposited	1 year, 10 months ago (Oct. 16, 2023, 8:44 a.m.)
Indexed	3 days, 12 hours ago (Aug. 21, 2025, 2:02 p.m.)
Issued	14 years, 9 months ago (Nov. 12, 2010)
Published	14 years, 9 months ago (Nov. 12, 2010)
Published Online	14 years, 9 months ago (Nov. 12, 2010)
Published Print	14 years, 7 months ago (Jan. 3, 2011)

Funders 0

None

BibTeX

@article{Wilson_2010, title={Synthesis and Application of Isocyanates Radiolabeled with Carbon‐11}, volume={17}, ISSN={1521-3765}, url={http://dx.doi.org/10.1002/chem.201002345}, DOI={10.1002/chem.201002345}, number={1}, journal={Chemistry – A European Journal}, publisher={Wiley}, author={Wilson, Alan A. and Garcia, Armando and Houle, Sylvain and Sadovski, Oleg and Vasdev, Neil}, year={2010}, month=nov, pages={259–264} }

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