DOI: 10.1002/chem.200306073. Self‐Assembled Monolayers of Dendritic Polyglycerol Derivatives on Gold That Resist the Adsorption of Proteins

Self‐Assembled Monolayers of Dendritic Polyglycerol Derivatives on Gold That Resist the Adsorption of Proteins

10.1002/chem.200306073

Crossref journal-article

Wiley

Chemistry – A European Journal (311)

Abstract

AbstractHighly protein‐resistant, self‐assembled monolayers (SAMs) of dendritic polyglycerols (PGs) on gold can easily be obtained by simple chemical modification of these readily available polymers with a surface‐active disulfide linker group. Several disulfide‐functionalized PGs were synthesized by N,N′‐dicyclohexylcarbodiimide‐mediated ester coupling of thioctic acid. Monolayers of the disulfide‐functionalized PG derivatives spontaneously form on a semitransparent gold surface and effectively prevent the adsorption of proteins, as demonstrated by surface plasmon resonance (SPR) kinetic measurements. A structure–activity relationship relating the polymer architecture to its ability to effectuate protein resistance has been derived from results of different surface characterization techniques (SPR, attenuated total reflectance infrared (ATR‐IR), and contact‐angle measurements). Dendritic PGs combine the characteristic structural features of several highly protein‐resistant surfaces: a highly flexible aliphatic polyether, hydrophilic surface groups, and a highly branched architecture. PG monolayers are as protein resistant as poly(ethylene glycol) (PEG) SAMs and are significantly better than dextran‐coated surfaces, which are currently used as the background for SPR spectroscopy. Due to the higher thermal and oxidative stability of the bulk PG as compared to the PEG and the easy accessibility of these materials, dendritic polyglycerols are novel and promising candidates as surface coatings for biomedical applications.

Bibliography

Siegers, C., Biesalski, M., & Haag, R. (2004). SelfâAssembled Monolayers of Dendritic Polyglycerol Derivatives on Gold That Resist the Adsorption of Proteins. Chemistry â A European Journal, 10(11), 2831â2838. Portico.

Authors 3

Conrad Siegers (first)
Markus Biesalski (additional)
Rainer Haag (additional)

References 52 Referenced 266

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Dates

Type	When
Created	21 years, 4 months ago (April 26, 2004, 11:03 a.m.)
Deposited	1 year, 10 months ago (Oct. 16, 2023, 9:57 a.m.)
Indexed	3 months, 2 weeks ago (May 13, 2025, 8:09 p.m.)
Issued	21 years, 2 months ago (June 4, 2004)
Published	21 years, 2 months ago (June 4, 2004)
Published Online	21 years, 2 months ago (June 4, 2004)
Published Print	21 years, 2 months ago (June 7, 2004)

Funders 0

None

BibTeX

@article{Siegers_2004, title={Self‐Assembled Monolayers of Dendritic Polyglycerol Derivatives on Gold That Resist the Adsorption of Proteins}, volume={10}, ISSN={1521-3765}, url={http://dx.doi.org/10.1002/chem.200306073}, DOI={10.1002/chem.200306073}, number={11}, journal={Chemistry – A European Journal}, publisher={Wiley}, author={Siegers, Conrad and Biesalski, Markus and Haag, Rainer}, year={2004}, month=jun, pages={2831–2838} }

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