Crossref journal-article
Wiley
Chemische Berichte (311)
Abstract

Synthesis of O‐Protected (R)‐2‐Hydroxy Aldehydes and Their HydrocyanationThe synthesis of O‐silyl‐ and O‐benzyl‐protected (R)‐2‐hydroxy aldehydes (R)‐6 from (R)‐2‐hydroxy carboxylic acids (R)‐1 is described. While attempts for their diastereoselective hydrocyanation with hydrocyanic acid and (R)‐oxynitrilase as catalyst have not been successful, the cyano silylation with trimethylsilyl cyanide occurred diastereoselectively with a ratio of 81 : 19 preferring the threo form without racemization at C‐2 of the 2‐hydroxy aldehyde.

Bibliography

Effenberger, F., Hopf, M., Ziegler, T., & Hudelmayer, J. (1991). Darstellung O‐geschützter (R)‐2‐Hydroxyaldehyde und ihre Hydrocyanierung. Chemische Berichte, 124(7), 1651–1659. Portico.

Authors 4
  1. Franz Effenberger (first)
  2. Martin Hopf (additional)
  3. Thomas Ziegler (additional)
  4. Jochen Hudelmayer (additional)
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Dates
Type When
Created 18 years, 1 month ago (July 2, 2007, 1:12 p.m.)
Deposited 1 year, 9 months ago (Nov. 23, 2023, 10:18 a.m.)
Indexed 1 year, 9 months ago (Nov. 23, 2023, 7:20 p.m.)
Issued 34 years, 1 month ago (July 1, 1991)
Published 34 years, 1 month ago (July 1, 1991)
Published Online 19 years, 7 months ago (Jan. 23, 2006)
Published Print 34 years, 1 month ago (July 1, 1991)
Funders 0

None

@article{Effenberger_1991, title={Darstellung O‐geschützter (R)‐2‐Hydroxyaldehyde und ihre Hydrocyanierung}, volume={124}, ISSN={0009-2940}, url={http://dx.doi.org/10.1002/cber.19911240728}, DOI={10.1002/cber.19911240728}, number={7}, journal={Chemische Berichte}, publisher={Wiley}, author={Effenberger, Franz and Hopf, Martin and Ziegler, Thomas and Hudelmayer, Jochen}, year={1991}, month=jul, pages={1651–1659} }