DOI: 10.1002/bjs.6986. Intraoperative near-infrared image-guided surgery for peritoneal carcinomatosis in a preclinical experimental model

Intraoperative near-infrared image-guided surgery for peritoneal carcinomatosis in a preclinical experimental model

10.1002/bjs.6986

Crossref journal-article

Oxford University Press (OUP)

British Journal of Surgery (286)

Abstract

Abstract Background This study compared the quality of surgery performed under conventional light with near-infrared (NIR) image-guided surgery using a tumour-targeting probe and a portable clinical grade imaging device in a mouse model of peritoneal carcinomatosis. Methods Peritoneal carcinomatosis was induced by injection of luciferase-positive tumour cells, leading to the formation of small nodules in the peritoneal cavity. One day after intravenous injection of RAFT-c(RGDfK)4-Alexa Fluor® 700, a fluorescent tumour-targeting probe, the surgeon operated using the Fluobeam®, a portable device that illuminated the mouse with NIR light and allowed NIR vision. The quality of the surgery was evaluated using bioluminescence, a highly sensitive method that detected the remaining tumour cells, and operating time was measured. Results Under normal light, the surgeon detected and removed a mean(s.d.) of only 50·6(2·3) per cent of the nodules that were visible under NIR light. The duration of surgery was reduced from 19·5(3·3) min under normal light to 14·0(2·6) min when NIR light was used (P = 0·025). The sensitivity of the NIR system allowed the detection of nodules containing as few as 227 tumour cells. Conclusion NIR image-guided surgery improved the quality of surgery for peritoneal carcinomatosis by doubling the number of nodules detected and significantly reducing the duration of surgery.

Bibliography

Keramidas, M., Josserand, V., Righini, C. A., Wenk, C., Faure, C., & Coll, J. L. (2010). Intraoperative near-infrared image-guided surgery for peritoneal carcinomatosis in a preclinical experimental model. British Journal of Surgery, 97(5), 737â743.

Authors 6

M Keramidas (first)
V Josserand (additional)
C A Righini (additional)
C Wenk (additional)
C Faure (additional)
J L Coll (additional)

References 21 Referenced 55

{'key': '2021070910464620900_bib1', 'first-page': '1142', 'article-title': 'Intraoperative immunophotodetection for radical resection of cancers: evaluation in an experimental model', 'volume': '7', 'author': 'Gutowski', 'year': '2001', 'journal-title': 'Clin Cancer Res'} / Clin Cancer Res / Intraoperative immunophotodetection for radical resection of cancers: evaluation in an experimental model by Gutowski (2001)
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Dates

Type	When
Created	15 years, 5 months ago (March 22, 2010, 9:21 a.m.)
Deposited	4 years, 1 month ago (July 9, 2021, 4:14 p.m.)
Indexed	6 months, 1 week ago (Feb. 21, 2025, 3:21 a.m.)
Issued	15 years, 5 months ago (March 22, 2010)
Published	15 years, 5 months ago (March 22, 2010)
Published Online	15 years, 5 months ago (March 22, 2010)
Published Print	15 years, 4 months ago (April 9, 2010)

Funders 5

Institut National de la Santé et de la Recherche Médicale 10.13039/501100001677
Region: Europe
gov (Research institutes and centers)
Labels4
1. French National Institute for Health and Medical Research
2. French National Institute of Health & Medical Research
3. National Institute of Health and Medical Research
4. Inserm
Institut National du Cancer 10.13039/501100006364 Institut National Du Cancer
Region: Europe
pri (Research institutes and centers)
Labels2
1. The French National Cancer Institute
2. INCa
Association pour la Recherche sur le Cancer 10.13039/100007391
Region: Europe
pri (Associations and societies (private and public))
Labels1
1. ARC
Agence Nationale pour la Recherche 10.13039/501100006744 Agence Nationale pour la Gestion des Déchets Radioactifs
Region: Europe
gov (National government)
Labels2
1. National Agency for Radioactive Waste Management
2. ANDRA
Small Animal Imaging Platform of the University Joseph Fourier 10.13039/501100008086 Université Joseph Fourier
Region: Europe
gov (Local government)
Labels2
1. Joseph Fourier University
2. UJF

BibTeX

@article{Keramidas_2010, title={Intraoperative near-infrared image-guided surgery for peritoneal carcinomatosis in a preclinical experimental model}, volume={97}, ISSN={1365-2168}, url={http://dx.doi.org/10.1002/bjs.6986}, DOI={10.1002/bjs.6986}, number={5}, journal={British Journal of Surgery}, publisher={Oxford University Press (OUP)}, author={Keramidas, M and Josserand, V and Righini, C A and Wenk, C and Faure, C and Coll, J L}, year={2010}, month=mar, pages={737–743} }

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  "issued": {
    "date-parts": [
      [
        2010,
        3,
        22
      ]
    ]
  },
  "references-count": 21,
  "journal-issue": {
    "issue": "5",
    "published-online": {
      "date-parts": [
        [
          2010,
          3,
          22
        ]
      ]
    },
    "published-print": {
      "date-parts": [
        [
          2010,
          4,
          9
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1002/bjs.6986",
  "relation": {},
  "ISSN": [
    "0007-1323",
    "1365-2168"
  ],
  "subject": [],
  "published-other": {
    "date-parts": [
      [
        2010,
        5
      ]
    ]
  },
  "published": {
    "date-parts": [
      [
        2010,
        3,
        22
      ]
    ]
  }
}