DOI: 10.1002/bjs.1800821034. Prospective study of prognostic factors in patients with unresected hepatic metastases from colorectal cancer

Prospective study of prognostic factors in patients with unresected hepatic metastases from colorectal cancer

10.1002/bjs.1800821034

Crossref journal-article

Oxford University Press (OUP)

Journal of British Surgery (286)

Abstract

Abstract Prognostic factors of unresected liver metastases in patients with colorectal cancer are not well established. A total of 544 patients with unresected liver metastases from colorectal cancer were registered in a national survey over a 1-year period and followed until death. Twenty factors were studied in a univariate analysis (log rank test) and 16 influenced survival (P&lt;0±01). These 16 factors were entered in a multivariate analysis (Cox model) and eight, ranging from the most significant (relative risk of death 1±9) to the less significant (relative risk of death 1±2), independently influenced survival: performance status, alkaline phosphatase level, number of involved liver segments, administration of chemotherapy, presence of extrahepatic metastases, site of the primary tumour, prothrombin time and resection of the primary lesion. Two simple classifications are proposed, taking into account the performance status and the alkaline phosphatase level, or the performance status and the number of involved liver segments.

Bibliography

Rougier, P., Milan, C., Lazorthes, F., Fourtanier, G., Partensky, C., Baumel, H., & Faivre, J. (1995). Prospective study of prognostic factors in patients with unresected hepatic metastases from colorectal cancer. Journal of British Surgery, 82(10), 1397â1400.

Authors 7

Ph Rougier (first)
C Milan (additional)
F Lazorthes (additional)
G Fourtanier (additional)
C Partensky (additional)
H Baumel (additional)
J Faivre (additional)

References 21 Referenced 152

10.1097/00000658-198502000-00012 / Ann Surg / Major hepatic resection for metachronous metastases from colon cancer by Cady (1985)
{'key': '2024092815133641400_bib2', 'first-page': '155', 'volume-title': 'Neoplasm of the Colon, Rectum and Anus', 'author': 'Kemeny', 'year': '1980'} / Neoplasm of the Colon, Rectum and Anus by Kemeny (1980)
{'key': '2024092815133641400_bib3', 'first-page': '278', 'article-title': 'Registry of Hepatic Metastases. Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of indications for resection', 'volume': '103', 'year': '1988', 'journal-title': 'Surgery'} / Surgery / Registry of Hepatic Metastases. Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of indications for resection (1988)
{'key': '2024092815133641400_bib4', 'first-page': '141', 'volume-title': 'Traitement des Métastases Hépatiques des Cancers Colorectaux', 'author': 'Nordlinger', 'year': '1992'} / Traitement des Métastases Hépatiques des Cancers Colorectaux by Nordlinger (1992)
10.1080/01621459.1958.10501452 / J Am Stat Assoc / Nonparametric estimations for incomplete observations by Kaplan (1958)
10.1038/bjc.1977.1 / Br J Cancer / Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples by Peto (1977)
10.1111/j.2517-6161.1972.tb00899.x / Journal of the Royal Statistical Society (B) / Regression models and life-tables by Cox (1972)
{'key': '2024092815133641400_bib8', 'first-page': '1', 'article-title': 'Factors influencing survival in patients with untreated hepatic metastases', 'volume': '127', 'author': 'Jaffe', 'year': '1968', 'journal-title': 'Surg Gynecol Obstet'} / Surg Gynecol Obstet / Factors influencing survival in patients with untreated hepatic metastases by Jaffe (1968)
{'key': '2024092815133641400_bib9', 'first-page': '217', 'volume-title': 'Progress in Cancer Vol VII', 'author': 'Pettavel', 'year': '1978'} / Progress in Cancer Vol VII by Pettavel (1978)
{'key': '2024092815133641400_bib10', 'first-page': '285', 'article-title': 'A retrospective study of the natural history of patients with liver metastases from colorectal cancer', 'volume': '2', 'author': 'Wood', 'year': '1976', 'journal-title': 'Clin Oncol'} / Clin Oncol / A retrospective study of the natural history of patients with liver metastases from colorectal cancer by Wood (1976)
10.1016/0002-9610(81)90057-X / Am J Surg / Natural history of patients with untreated liver metastases from colorectal cancer by Bengtsson (1981)
10.1007/BF02553304 / Dis Colon Rectum / Factors influencing survival in patients with hepatic metastases from adenocarcinoma of the colon or rectum by Goslin (1982)
10.1097/00000658-198405000-00002 / Ann Surg / The natural history of hepatic metastases from colorectal cancer. A comparison with resective treatment by Wagner (1984)
10.1200/JCO.1983.1.11.720 / J. Clin Oncol / A multifactorial analysis of prognostic factors in patients with liver metastases from colorectal carcinoma by Lahr (1983)
10.1200/JCO.1984.2.3.174 / J Clin Oncol / Prognostic factors influencing survival of patients with advanced colorectal cancer: hepatic-artery infusion versus systemic intravenous chemotherapy for liver metastases by Bedikian (1984)
10.1200/JCO.1984.2.6.595 / J Clin Oncol / Hepatic artery pump infusion: toxicity and results in patients with metastatic colorectal carcinoma by Kemeny (1984)
10.1136/bmj.306.6880.752 / BMJ / Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer by Scheithauer (1993)
10.1200/JCO.1988.6.3.469 / J Clin Oncol / A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma by Erlichman (1988)
10.1200/JCO.1989.7.10.1407 / J Clin Oncol / Biomedical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma by Poon (1989)
10.1200/JCO.1989.7.10.1437 / J Clin Oncol / Nordic Gastrointestinal Tumor Adjuvant Therapy Group. Superiority of sequential methotrexate, fluorouracil and leucovorin to 5-fluorouracil alone in advanced symptomatic colorectal carcinoma: a randomized trial by Glimelius (1989)
10.1200/JCO.1992.10.6.904 / J Clin Oncol / Expectancy or primary chemotherapy in patients with advanced asymptomatic colorectal cancer: a randomized trial by Nordic Gastrointestinal Tumor Adjuvant Therapy Group (1992)

Dates

Type	When
Created	18 years, 5 months ago (March 3, 2007, 4:17 p.m.)
Deposited	11 months ago (Sept. 28, 2024, 11:13 a.m.)
Indexed	1 month, 1 week ago (July 22, 2025, 6:56 a.m.)
Issued	29 years, 10 months ago (Oct. 1, 1995)
Published	29 years, 10 months ago (Oct. 1, 1995)
Published Online	29 years, 10 months ago (Oct. 1, 1995)
Published Print	29 years, 10 months ago (Oct. 1, 1995)

Funders 1

French League Against Cancer 10.13039/501100011733 Liga Portuguesa Contra o Cancro
Region: Europe
pri (Other non-profit organizations)
Labels2
1. Portuguese League Against Cancer
2. LPCC

BibTeX

@article{Rougier_1995, title={Prospective study of prognostic factors in patients with unresected hepatic metastases from colorectal cancer}, volume={82}, ISSN={1365-2168}, url={http://dx.doi.org/10.1002/bjs.1800821034}, DOI={10.1002/bjs.1800821034}, number={10}, journal={Journal of British Surgery}, publisher={Oxford University Press (OUP)}, author={Rougier, Ph and Milan, C and Lazorthes, F and Fourtanier, G and Partensky, C and Baumel, H and Faivre, J}, year={1995}, month=oct, pages={1397–1400} }

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