DOI: 10.1002/bip.1969.360070506. Matching of single‐strand breaks to form double‐strand breaks in DNA

Matching of single‐strand breaks to form double‐strand breaks in DNA

10.1002/bip.1969.360070506

Crossref journal-article

Wiley

Biopolymers (311)

Abstract

AbstractSingle‐strand breaks (ssb) in opposite strands of DNA can be sufficiently near that a double‐strand break (dsb) results. A theory is presented by which the maximum number h of base pairs which cannot prevent double‐strand breakage can be determined from the rates of production of ssb and dsb. The assumptions required to derive the necessary equations as well as the range of validity of the equations are discussed in detail. In the experiments ssb and dsb were produced by x‐irradiation in buffers which do not eliminate indirect effects and were measured by analytical ultracentrifugation. Values of h have been determined in low and high ionic strength and in low ionic strength over a range of temperatures. The values, 2.64 and 15.8, were obtained for high and low ionic strength, respectively.

Bibliography

Freifelder, D., & Trumbo, B. (1969). Matching of singleâstrand breaks to form doubleâstrand breaks in DNA. Biopolymers, 7(5), 681â693. Portico.

Authors 2

David Freifelder (first)
Bruce Trumbo (additional)

References 12 Referenced 137

10.2307/3572016
10.1021/ja01590a023
10.1016/0005-2787(67)90695-8
10.1016/0005-2787(67)90088-3
10.1016/S0022-2836(62)80092-8
10.1016/S0021-9258(18)64321-2
10.1016/S0022-2836(64)80142-X
10.1016/S0022-2836(66)80187-0
{'key': 'e_1_2_1_10_2', 'first-page': '34', 'volume-title': 'Mechanisms in Radiobiology', 'author': 'Hutchison F. W.', 'year': '1961'} / Mechanisms in Radiobiology by Hutchison F. W. (1961)
10.1073/pnas.54.1.128
10.1016/S0021-9258(19)67936-6
10.1016/0926-6550(63)90433-X

Dates

Type	When
Created	20 years, 3 months ago (May 27, 2005, 11:16 a.m.)
Deposited	1 year, 10 months ago (Oct. 19, 2023, 6:39 a.m.)
Indexed	1 week, 2 days ago (Aug. 22, 2025, 12:46 a.m.)
Issued	56 years, 3 months ago (May 1, 1969)
Published	56 years, 3 months ago (May 1, 1969)
Published Online	21 years, 6 months ago (Feb. 1, 2004)
Published Print	56 years, 3 months ago (May 1, 1969)

Funders 0

None

BibTeX

@article{Freifelder_1969, title={Matching of single‐strand breaks to form double‐strand breaks in DNA}, volume={7}, ISSN={1097-0282}, url={http://dx.doi.org/10.1002/bip.1969.360070506}, DOI={10.1002/bip.1969.360070506}, number={5}, journal={Biopolymers}, publisher={Wiley}, author={Freifelder, David and Trumbo, Bruce}, year={1969}, month=may, pages={681–693} }

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