DOI: 10.1002/bip.1966.360040808. Validity of the “two‐state” hypothesis for conformational transitions of proteins

Validity of the “two‐state” hypothesis for conformational transitions of proteins

10.1002/bip.1966.360040808

Crossref journal-article

Wiley

Biopolymers (311)

Abstract

AbstractThe theory, character, and properties of cooperative transitions are developed with special reference to the abrupt changes of state which occur in protein solutions. Comparisons of helix–coil processes and protein conformational reactions show that though cooperation dominates both of these processes, there are important differences. Tests of two types for the validity of the two‐state approximation are presented with specific applications to proteins. Available experimental evidence demonstrates that the thermally induced reversible transitions of ribonuclease, α‐chymotrypsin, and chymotrypsinogen A under conditions thus far examined are two‐state processes.

Bibliography

Lumry, R., Biltonen, R., & Brandts, J. F. (1966). Validity of the âtwoâstateâ hypothesis for conformational transitions of proteins. Biopolymers, 4(8), 917â944. Portico.

Authors 3

Rufus Lumry (first)
Rodney Biltonen (additional)
John F. Brandts (additional)

References 26 Referenced 286

{'key': 'e_1_2_1_2_2', 'volume-title': 'The Kinetic Basis of Molecular Biology', 'author': 'Johnson F.', 'year': '1954'} / The Kinetic Basis of Molecular Biology by Johnson F. (1954)
10.1002/bip.1965.360030405
10.1021/ja01064a028
10.1021/j100889a013
10.1021/ja01082a036
R.Biltonen Dissertation University of Minnesota 1965.
10.1021/ja01074a013
10.1021/ja01074a014
R.Lnmry andR.Biltonen inBiopolymers S. Timasheff and G. Fasman Eds. Dekker New York in press.
{'issue': '6', 'key': 'e_1_2_1_11_2', 'first-page': '125', 'author': 'Luinry R.', 'year': '1964', 'journal-title': 'Abh. Deut. Akad. Wissen. Berlin, Jenaer Symp.'} / Abh. Deut. Akad. Wissen. Berlin, Jenaer Symp. by Luinry R. (1964)
{'key': 'e_1_2_1_12_2', 'volume-title': 'Thermodynamis of Small Systems', 'author': 'Hill T.', 'year': '1963'} / Thermodynamis of Small Systems by Hill T. (1963)
10.1021/ja01090a043
10.1021/ja01476a025
C.Martin J. Am. Chem. Soc. in press.
{'key': 'e_1_2_1_16_2', 'first-page': '790', 'volume': '85', 'author': 'Havsteen H.', 'year': '1963', 'journal-title': 'J. Am. Chem. Soc.'} / J. Am. Chem. Soc. by Havsteen H. (1963)
10.1085/jgp.34.5.583
10.1021/j100801a021
10.1021/j100816a041
D. N.Holcomb Dissertation University of Illinois 1962.
E.Benson B.Hallaway andR.Lumry to be published.
J.Brandts unpublished observations.
10.1021/bi00896a008
10.1073/pnas.54.2.640
J.Sullivan Dissertation University of Minnesota 1966.
10.1002/bip.1964.360020507
10.1080/00268976000100441

Dates

Type	When
Created	20 years, 7 months ago (Dec. 29, 2004, 5 a.m.)
Deposited	1 year, 10 months ago (Oct. 19, 2023, 12:15 p.m.)
Indexed	1 month, 1 week ago (July 16, 2025, 7:44 a.m.)
Issued	58 years, 11 months ago (Sept. 1, 1966)
Published	58 years, 11 months ago (Sept. 1, 1966)
Published Online	21 years, 6 months ago (Feb. 1, 2004)
Published Print	58 years, 11 months ago (Sept. 1, 1966)

Funders 0

None

BibTeX

@article{Lumry_1966, title={Validity of the “two‐state” hypothesis for conformational transitions of proteins}, volume={4}, ISSN={1097-0282}, url={http://dx.doi.org/10.1002/bip.1966.360040808}, DOI={10.1002/bip.1966.360040808}, number={8}, journal={Biopolymers}, publisher={Wiley}, author={Lumry, Rufus and Biltonen, Rodney and Brandts, John F.}, year={1966}, month=sep, pages={917–944} }

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