DOI: 10.1002/bip.1966.360040605. Effect of aggregation on the optical rotatory dispersion of poly(α,<scp>L</scp>‐glutamic acid)

Effect of aggregation on the optical rotatory dispersion of poly(α,L‐glutamic acid)

10.1002/bip.1966.360040605

Crossref journal-article

Wiley

Biopolymers (311)

Abstract

AbstractLight‐scattering measurements show that poly(α,L‐glutamic acid) (PGA) is strongly aggregated at the low pH's (4.0–4.3) usually used to measure the mean residue rotation at the trough, [R′]233, and that [R′]233 becomes more negative with aggregation. Concurrent weight‐average molecular weight measurements by light‐scattering and [R′]233 measurements by optical rotatory dispersion as a function of pH show that a maximum negative value for [R′]233 (unaffected by aggregation) is obtained at higher pH's (4.53–4.82). Precautions should be taken to insure that the Na‐PGA sample used as standard does not aggregate at the low pH's required for its complete conversion to the helical form. An Na‐PGA sample meeting the above requirements gives [R′]233 of −14,600° ± 1.5% over the pH range 4.53–4.82 in 0.05M NaCl.

Bibliography

Tomimatsu, Y., Vitello, L., & Gaffield, W. (1966). Effect of aggregation on the optical rotatory dispersion of poly(Î±,Lâglutamic acid). Biopolymers, 4(6), 653â662. Portico.

Authors 3

Y. Tomimatsu (first)
L. Vitello (additional)
W. Gaffield (additional)

References 40 Referenced 59

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Dates

Type	When
Created	20 years, 8 months ago (Dec. 29, 2004, 4:57 a.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 8:58 a.m.)
Indexed	1 day, 21 hours ago (Sept. 4, 2025, 10:05 a.m.)
Issued	59 years, 3 months ago (June 1, 1966)
Published	59 years, 3 months ago (June 1, 1966)
Published Online	21 years, 7 months ago (Feb. 1, 2004)
Published Print	59 years, 3 months ago (June 1, 1966)

Funders 0

None

BibTeX

@article{Tomimatsu_1966, title={Effect of aggregation on the optical rotatory dispersion of poly(α,<scp>L</scp>‐glutamic acid)}, volume={4}, ISSN={1097-0282}, url={http://dx.doi.org/10.1002/bip.1966.360040605}, DOI={10.1002/bip.1966.360040605}, number={6}, journal={Biopolymers}, publisher={Wiley}, author={Tomimatsu, Y. and Vitello, L. and Gaffield, W.}, year={1966}, month=jun, pages={653–662} }

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