Abstract
AbstractA theory of site–site interaction due to proton/charge fluctuations in protein molecules has been developed. It is shown that, with the proper geometric configuration of identical ionizable groups on matching sites, a specific attraction may be established. This attractive force has a bell‐shaped pH dependence and is maximal close to the pK of the groups involved. Various types of protein interactions are examined in the light of this theory.
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Dates
Type | When |
---|---|
Created | 20 years, 8 months ago (Dec. 30, 2004, 10:24 p.m.) |
Deposited | 1 year, 10 months ago (Oct. 18, 2023, 2:20 p.m.) |
Indexed | 1 year, 9 months ago (Nov. 12, 2023, 9:54 a.m.) |
Issued | 59 years, 8 months ago (Jan. 1, 1966) |
Published | 59 years, 8 months ago (Jan. 1, 1966) |
Published Online | 21 years, 7 months ago (Feb. 1, 2004) |
Published Print | 59 years, 8 months ago (Jan. 1, 1966) |
@article{Timasheff_1966, title={Specific interactions in proteins due to proton fluctuations}, volume={4}, ISSN={1097-0282}, url={http://dx.doi.org/10.1002/bip.1966.360040112}, DOI={10.1002/bip.1966.360040112}, number={1}, journal={Biopolymers}, publisher={Wiley}, author={Timasheff, S. N.}, year={1966}, month=jan, pages={107–120} }