DOI: 10.1002/bies.950191204. Molecular neurogenetics of chemotaxis and thermotaxis in the nematode <i>Caenorhabditis elegans</i>

Molecular neurogenetics of chemotaxis and thermotaxis in the nematode Caenorhabditis elegans

10.1002/bies.950191204

Crossref journal-article

Wiley

BioEssays (311)

Abstract

AbstractChemotaxis and thermotaxis in Caenorhabditis elegans are based on the chemical senses (smell and taste) and the thermal sense, respectively, which are important for the life of the animal. Laser ablation experiments have allowed identification of sensory neurons and some interneurons required for these senses. Many mutants that exhibit various abnormalies have been isolated and analyzed. These studies have predicted novel signaling pathways whose components include a putative odorant specific transmembrane receptor (ODR‐10) and a cyclic nucleotide‐gated channel (TAX‐4/TAX‐2) functioning in taste and thermosensation as well as in smell. The emerging picture of the mechanisms of sensory transduction in C. elegans seems to be basically similar to what is known of visual and olfactory sensory transduction in vertebrates. Thus, molecular and cellular analyses of chemotaxis and thermotaxis in C. elegans have proved useful and will continue to provide significant implications for the molecular basis of sensory systems in higher animals.

Bibliography

Mori, I., & Ohshima, Y. (1997). Molecular neurogenetics of chemotaxis and thermotaxis in the nematode Caenorhabditis elegans. BioEssays, 19(12), 1055â1064. Portico.

Authors 2

Ikue Mori (first)
Yasumi Ohshima (additional)

References 72 Referenced 43

10.1093/genetics/77.1.71
{'key': 'e_1_2_1_3_2', 'first-page': '23', 'volume-title': 'C. elegans II', 'author': 'Waterston R. H.', 'year': '1997'} / C. elegans II by Waterston R. H. (1997)
10.1016/0012-1606(77)90158-0
10.1016/0012-1606(83)90201-4
10.1098/rstb.1986.0056
{'key': 'e_1_2_1_7_2', 'first-page': '337', 'volume-title': 'The Nematode Caenorhabditis elegans', 'author': 'Chalfie M.', 'year': '1988'} / The Nematode Caenorhabditis elegans by Chalfie M. (1988)
10.1146/annurev.ne.16.030193.000403
10.1002/j.1460-2075.1991.tb04966.x
10.1016/S0091-679X(08)61390-4
10.1073/pnas.70.3.817
10.1016/0896-6273(91)90276-6
10.1126/science.2006412
{'key': 'e_1_2_1_14_2', 'first-page': '739', 'volume-title': 'C. elegans II', 'author': 'Riddle D. L.', 'year': '1997'} / C. elegans II by Riddle D. L. (1997)
10.1093/genetics/90.2.243
10.1002/jez.1401930319
10.1101/SQB.1990.055.01.051
10.1016/0092-8674(93)80053-H
10.1073/pnas.72.10.4061
10.1007/BF00204698
10.1038/376344a0
{'key': 'e_1_2_1_22_2', 'first-page': '717', 'volume-title': 'C. elegans II', 'author': 'Bargmann C. I.', 'year': '1997'} / C. elegans II by Bargmann C. I. (1997)
10.1002/cne.901600305
10.1002/cne.901620106
10.1016/S0896-6273(00)80203-2
10.1073/pnas.90.6.2227
10.1016/0092-8674(95)90162-0
10.1016/0012-1606(86)90314-3
10.1523/JNEUROSCI.05-04-00956.1985
10.1093/genetics/80.2.297
10.1002/cne.901720306
10.1016/0012-1606(85)90443-9
10.1093/genetics/139.1.171
10.1093/genetics/138.2.303
10.1016/0092-8674(94)90028-0
10.1016/S0092-8674(00)81068-5
10.1007/BF00657114
10.1016/0092-8674(91)90418-X
10.1016/0092-8674(95)90161-2
10.1038/372270a0
10.1126/science.8303295
10.1146/annurev.ne.19.030196.001315
10.1038/345672a0
10.1016/S0896-6273(00)80201-9
10.1016/S0896-6273(00)80202-0
10.1016/S0896-6273(00)80200-7
10.1002/j.1460-2075.1990.tb07422.x
10.1523/JNEUROSCI.14-05-03304.1994 / J. Neurosci. / Single odors differentially stimulate dual second messenger pathways in lobster olfactory receptor cells by Boekhoff I. (1994)
10.1038/345065a0
10.1016/0896-6273(92)90243-7
10.1073/pnas.91.9.3505
10.1038/368859a0
10.1073/pnas.93.19.10440
10.1016/0896-6273(95)90074-8
10.1523/JNEUROSCI.17-06-01993.1997
10.1016/S0896-6273(00)80055-0
10.1016/0896-6273(94)90160-0
10.1016/0896-6273(94)90347-6
10.1038/349326a0
10.1016/S0896-6273(00)80944-7
10.1242/dev.121.6.1769 / Development / Control of neuronal pathway selection by the Drosophila LIM homeodomain gene apterous by Lundren S. E. (1995)
10.1073/pnas.90.1.227
10.1016/0012-1606(84)90201-X
10.1073/pnas.81.3.819
10.1126/science.274.5291.1389
10.1016/0896-6273(95)90224-4
10.1016/0006-8993(90)90605-B
10.1126/science.266.5189.1348
10.1016/0166-4328(90)90074-O
10.1037/0735-7044.111.2.354 / Behav. Neurosci. / Mutations that prevent associative learning in C. elegans. by Wen J. Y. M. (1997)
10.1073/pnas.94.7.3384
10.1073/pnas.90.16.7431
10.1093/genetics/145.3.715 / Genetics / Two neuronal G proteins are involved in chemosensation of the Caenorhabditis elegans dauer‐inducing phenromone by Zwaal R. R. (1997)

Dates

Type	When
Created	20 years, 6 months ago (Feb. 25, 2005, 6 a.m.)
Deposited	1 year, 9 months ago (Oct. 28, 2023, 12:39 a.m.)
Indexed	2 months, 3 weeks ago (June 2, 2025, 2:24 a.m.)
Issued	27 years, 8 months ago (Dec. 1, 1997)
Published	27 years, 8 months ago (Dec. 1, 1997)
Published Online	20 years, 6 months ago (Feb. 5, 2005)
Published Print	27 years, 8 months ago (Dec. 1, 1997)

Funders 0

None

BibTeX

@article{Mori_1997, title={Molecular neurogenetics of chemotaxis and thermotaxis in the nematode Caenorhabditis elegans}, volume={19}, ISSN={1521-1878}, url={http://dx.doi.org/10.1002/bies.950191204}, DOI={10.1002/bies.950191204}, number={12}, journal={BioEssays}, publisher={Wiley}, author={Mori, Ikue and Ohshima, Yasumi}, year={1997}, month=dec, pages={1055–1064} }

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