DOI: 10.1002/bies.950191011. Hypothesis: Ataxia‐telangiectasia: Is ATM a sensor of oxidative damage and stress?

Hypothesis: Ataxia‐telangiectasia: Is ATM a sensor of oxidative damage and stress?

10.1002/bies.950191011

Crossref journal-article

Wiley

BioEssays (311)

Abstract

AbstractAtaxia‐telangiectasia (A‐T) is a pleiotropic recessive disorder characterized cerebellar ataxia, immunodeficiency, specific developmental defects, profound predisposition to cancer and acute radiosensitivity. Functional inactivation of single gene product, ATM, accounts for this compound phenotype. We suggest that ATM acts as a sensor of reactive oxygen species and/or oxidative damage cellular macromolecules, including DNA. In turn, ATM induces signalling through multiple pathways, thereby coordinating acute phase stress responses with cell cycle checkpoint control and repair of oxidative damage. Absence of ATM is proposed to limit the repair of insidious oxidative damage that can occur under normal physiological conditions, ultimately leading to apoptosis of particularly sensitive cells, such as neurons and thymocytes.

Bibliography

Rotman, G., & Shiloh, Y. (1997). Hypothesis: Ataxiaâtelangiectasia: Is ATM a sensor of oxidative damage and stress? BioEssays, 19(10), 911â917. Portico.

Authors 2

Galit Rotman (first)
Yosef Shiloh (additional)

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Dates

Type	When
Created	20 years, 6 months ago (Feb. 25, 2005, 5:55 a.m.)
Deposited	1 year, 10 months ago (Oct. 27, 2023, 6:57 a.m.)
Indexed	5 months, 2 weeks ago (March 19, 2025, 12:40 p.m.)
Issued	27 years, 11 months ago (Oct. 1, 1997)
Published	27 years, 11 months ago (Oct. 1, 1997)
Published Online	20 years, 6 months ago (Feb. 5, 2005)
Published Print	27 years, 11 months ago (Oct. 1, 1997)

Funders 0

None

BibTeX

@article{Rotman_1997, title={Hypothesis: Ataxia‐telangiectasia: Is ATM a sensor of oxidative damage and stress?}, volume={19}, ISSN={1521-1878}, url={http://dx.doi.org/10.1002/bies.950191011}, DOI={10.1002/bies.950191011}, number={10}, journal={BioEssays}, publisher={Wiley}, author={Rotman, Galit and Shiloh, Yosef}, year={1997}, month=oct, pages={911–917} }

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