DOI: 10.1002/bies.950190210. Mechanism of gene expression by the glucocorticoid receptor: Role of protein‐protein interactions

Mechanism of gene expression by the glucocorticoid receptor: Role of protein‐protein interactions

10.1002/bies.950190210

Crossref journal-article

Wiley

BioEssays (311)

Abstract

AbstractThe glucocorticoid receptor belongs to an important class of transcription factors that alter the expression of target genes in response to a specific hormone signal. The glucocorticoid receptor can function at least at three levels: (1) recruitment of the general transcription machinery; (2) modulation of transcription factor action, independent of DNA binding, through direct protein‐protein interactions; and (3) modulation of chromatin structure to allow the assembly of other gene regulatory proteins and/or the general transcription machinery on the DNA. This review will focus on the multifaceted nature of protein‐protein interactions involving the glucocorticoid receptor and basal transcription factors, coactivators and other transcription factors, occurring at these different levels of regulation.

Bibliography

McEwan, I. J., Wright, A. P. H., & Gustafsson, J. (1997). Mechanism of gene expression by the glucocorticoid receptor: Role of proteinâprotein interactions. BioEssays, 19(2), 153â160. Portico.

Authors 3

Iain J. McEwan (first)
Anthony P. H. Wright (additional)
Jan‐Åke Gustafsson (additional)

References 70 Referenced 152

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Dates

Type	When
Created	20 years, 6 months ago (Feb. 25, 2005, 6:01 a.m.)
Deposited	1 year, 10 months ago (Oct. 28, 2023, 1:29 a.m.)
Indexed	14 minutes ago (Sept. 3, 2025, 6:54 p.m.)
Issued	28 years, 7 months ago (Feb. 1, 1997)
Published	28 years, 7 months ago (Feb. 1, 1997)
Published Online	20 years, 6 months ago (Feb. 5, 2005)
Published Print	28 years, 7 months ago (Feb. 1, 1997)

Funders 0

None

BibTeX

@article{McEwan_1997, title={Mechanism of gene expression by the glucocorticoid receptor: Role of protein‐protein interactions}, volume={19}, ISSN={1521-1878}, url={http://dx.doi.org/10.1002/bies.950190210}, DOI={10.1002/bies.950190210}, number={2}, journal={BioEssays}, publisher={Wiley}, author={McEwan, Iain J. and Wright, Anthony P. H. and Gustafsson, Jan‐Åke}, year={1997}, month=feb, pages={153–160} }

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